DOI: 10.1128/jb.95.4.1335-1342.1968. Plasmid-linked Resistance to Inorganic Salts in <i>Staphylococcus aureus</i>

Plasmid-linked Resistance to Inorganic Salts in Staphylococcus aureus

10.1128/jb.95.4.1335-1342.1968

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

The penicillinase plasmids, a series of extrachromosomal resistance factors in Staphylococcus aureus , were found to carry determinants of resistance to a series of inorganic ions as well as resistance to penicillin and, in some cases, erythromycin. Most of the ions involved were inhibitory but not lethal to the bacteria; the resistance markers conferred an increase in resistance by comparison with susceptible organisms of between 3- and 100-fold, depending on the ion involved. Separate genetic loci for resistance to arsenate, arsenite, lead, cadmium, mercuric, and bismuth ions were demonstrated. Resistance to antimony and resistance to zinc were also found but were not separated genetically from resistance to arsenite and cadmium, respectively. The ion resistance markers appeared to form a cluster on the plasmid, with no other known marker within it. Naturally occurring plasmids were observed that lacked one or more of these ion resistance markers, as well as penicillinase-negative strains that were resistant to one or more of the ions. The patterns of markers carried by these various strains may provide some understanding of the evolution of a plasmid linkage group.

Bibliography

Novick, R. P., & Roth, C. (1968). Plasmid-linked Resistance to Inorganic Salts in Staphylococcus aureus. Journal of Bacteriology, 95(4), 1335â1342.

Authors 2

Richard P. Novick (first)
Christine Roth (additional)

References 12 Referenced 313

ASHESHOV , E. H. 1966 . Chromosomal location of the genetic elements controlling penicillinase production in a strain of Staphylococcus aureus . Nature 210 : 804 - 806 . (10.1038/210804a0) / Nature / Chromosomal location of the genetic elements controlling penicillinase production in a strain of Staphylococcus aureus by ASHESHOV E. H. (1966)
GINOZA , H. S. , AND R. B. PAINTER. 1964 . Genetic recombination between the resistance transfer factor and the chromosome of Escherichia coli . J. Bacteriol. 87 : 1339 - 1345 . (10.1128/JB.87.6.1339-1345.1964) / J. Bacteriol. / Genetic recombination between the resistance transfer factor and the chromosome of Escherichia coli by GINOZA H. S. (1964)
MMUHASHI , S., M. MORIMURA , K. KoNo, AND H. OSHIMA. 1963 . Elimination of drug resistance of Staphylococcus aureus by treatment with acriflavine . J. Bacteriol. 86 : 162 - 164 . (10.1128/JB.86.1.162-164.1963) / J. Bacteriol. / Elimination of drug resistance of Staphylococcus aureus by treatment with acriflavine by MMUHASHI S., M. (1963)
Moo RE , B. 1960 . A new screen test and selective medium for the rapid detection of epidemic strains of Staph. aureus . Lancet 2 : 453 - 458 . / Lancet / A new screen test and selective medium for the rapid detection of epidemic strains of Staph. aureus by RE B. (1960)
NoV1 CK , R. P. 1963 . Analysis by transduction of mutations affecting penicillinase formation in Staphylococcus aureus . J. Gen. Microbiol. 33 : 121 - 136 . (10.1099/00221287-33-1-121) / J. Gen. Microbiol. / Analysis by transduction of mutations affecting penicillinase formation in Staphylococcus aureus by CK R. P. (1963)
Nov ICK , R. P. 1967 . Penicillinase plasmids of Staphylococcus aureus . Federation Proc. 26 : 29 - 38 . / Federation Proc. / Penicillinase plasmids of Staphylococcus aureus by ICK R. P. (1967)
NOVICK , R. P. , AND M. H. RICHMOND. 1965 . Nature and interactions of the genetic elements governing penicillinase synthesis in Staphylococcus aureus . J. Bacteriol. 90 : 467 - 480 . (10.1128/JB.90.2.467-480.1965) / J. Bacteriol. / Nature and interactions of the genetic elements governing penicillinase synthesis in Staphylococcus aureus by NOVICK R. P. (1965)
POSTON , S. M. 1966 . Cellular location of the genes controlling penicillinase production and resistance to streptomycin and tetracycline in a strain of Staphylococcus aureus . Nature 210 : 802 - 804 . (10.1038/210802a0) / Nature / Cellular location of the genes controlling penicillinase production and resistance to streptomycin and tetracycline in a strain of Staphylococcus aureus by POSTON S. M. (1966)
RICHMOND , M. H. 1967 . A second regulatory region involved in penicillinase synthesis in Staphylococcus aureus . J. Mol. Biol. 26 : 357 - 360 . (10.1016/0022-2836(67)90305-1) / J. Mol. Biol. / A second regulatory region involved in penicillinase synthesis in Staphylococcus aureus by RICHMOND M. H. (1967)
RICHMOND , M. H. , AND M. JOHN. 1964 . Cotransduction by a staphylococcal phage of the genes responsible for penicillinase synthesis and resistance to mercury salts . Nature 202 : 1360 - 1361 . (10.1038/2021360a0) / Nature / Cotransduction by a staphylococcal phage of the genes responsible for penicillinase synthesis and resistance to mercury salts by RICHMOND M. H. (1964)
SMITH , D. H. 1967 . R factors mediate resistance to mercury, nickel, and cobalt . Science 156 : 1114 - 1116 . (10.1126/science.156.3778.1114) / Science / R factors mediate resistance to mercury, nickel, and cobalt by SMITH D. H. (1967)
WATANABE , T. 1963 . Infective heredity of multiple drug resistance in bacteria . Bacteriol. Rev. 27 : 87 - 115 . (10.1128/BR.27.1.87-115.1963) / Bacteriol. Rev. / Infective heredity of multiple drug resistance in bacteria by WATANABE T. (1963)

Dates

Type	When
Created	5 years, 7 months ago (Jan. 4, 2020, 9:07 p.m.)
Deposited	4 years, 1 month ago (July 29, 2021, 12:47 p.m.)
Indexed	3 weeks, 4 days ago (Aug. 5, 2025, 9:01 a.m.)
Issued	57 years, 4 months ago (April 1, 1968)
Published	57 years, 4 months ago (April 1, 1968)
Published Print	57 years, 4 months ago (April 1, 1968)

Funders 0

None

BibTeX

@article{Novick_1968, title={Plasmid-linked Resistance to Inorganic Salts in Staphylococcus aureus}, volume={95}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.95.4.1335-1342.1968}, DOI={10.1128/jb.95.4.1335-1342.1968}, number={4}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Novick, Richard P. and Roth, Christine}, year={1968}, month=apr, pages={1335–1342} }

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