DOI: 10.1128/jb.90.3.696-703.1965. High Susceptibility of Strain A Mice to Endotoxin and Endotoxin-Red Blood Cell Mixtures

High Susceptibility of Strain A Mice to Endotoxin and Endotoxin-Red Blood Cell Mixtures

10.1128/jb.90.3.696-703.1965

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

Heppner, Gloria (University of California, Berkeley), and David W. Weiss . High susceptibility of strain A mice to endotoxin and endotoxin-red blood cell mixtures. J. Bacteriol. 90: 696–703. 1965.—Strain A mice were shown to be considerably more susceptible to lethal effects of endotoxin lipopolysaccharide (LPS) than mice of several other strains. Complexes of sublethal quantities of LPS and sheep red blood cells were synergistically toxic for strain A mice. Separate administration of sheep red blood cells and heat-killed salmonellae, in either order and as long as 24 hr apart, also proved to be synergistically lethal for strain A mice, but not for R III animals studied comparatively. Sheep red blood cell lysates possessed the ability of the intact cells in forming lethal combinations for strain A mice with killed salmonellae. Strain A red blood cell-killed salmonellae complexes were also lethal for strain A mice, but less so then complexes made with sheep red blood cells. A × R III F 1 hybrid animals showed the same resistance characteristics as the resistant R III parental strain. Possible explanations for these findings are suggested, and their relevance to an immunological mode of action of endotoxin lethality is discussed.

Bibliography

Heppner, G., & Weiss, D. W. (1965). High Susceptibility of Strain A Mice to Endotoxin and Endotoxin-Red Blood Cell Mixtures. Journal of Bacteriology, 90(3), 696â703.

Authors 2

Gloria Heppner (first)
David W. Weiss (additional)

References 20 Referenced 86

DAVIDSOHN , I. , AND K. STERN. 1954 . Heterohemoantibodies and hemolysins in inbred strains of mice. II. Immune agglutinins and hemolysins for sheep and chicken red cells . J. Immunol. 72 : 216 - 223 . / J. Immunol. / Heterohemoantibodies and hemolysins in inbred strains of mice. II. Immune agglutinins and hemolysins for sheep and chicken red cells by DAVIDSOHN I. (1954)
DAVIS , J. H. , AND A. B. YULL. 1961 . The red blood cell: an essential component of the toxicity of strangulation intestinal obstruction . Proc. Soc. Exptl. Biol. Med. 108 : 252 - 253 . (10.3181/00379727-108-26906) / Proc. Soc. Exptl. Biol. Med. / The red blood cell: an essential component of the toxicity of strangulation intestinal obstruction by DAVIS J. H. (1961)
FINE J. 1964. Some observations on the mechanism of action of bacterial endotoxin p. 588-595. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J.
FORBUS W. D. 1952. Reaction to injury p. 33. The Williams & Wilkins Co. Baltimore.
GLADSTONE G. P. 1962. Pathogenicity and virulence of microorganisms p. 746. In H. Florey [ed.] General pathology 3rd ed. W. B. Saunders Co. Philadelphia.
HEILMAN D. H. 1964. Cellular aspects of the action of endotoxin: the role of the macrophage p. 610-617. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J.
HILL G. J. AND D. W. WEISS. 1964. Relationships between susceptibility of mice to heat-killed salmonellae and endotoxin and the affinity of their red blood cells for killed organisms p. 422-427. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J.
JANOFF A. AND G. KALEY. 1964. Studies on Iysosomes in tolerance shock and local injury induced by endotoxin p. 631-647. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J.
JOHNSON A. G. 1964. Adjuvant action of bacterial endotoxins on the primary antibody response p. 256-262. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J.
KLEIN , E. , AND 0. LI NDER . 1961 . Factorial analysis of the reactivity of C57B1 females against isologous male skin grafts . Transplant Bull. 27 : 457 - 459 . (10.1097/00006534-196104000-00043) / Transplant Bull. / Factorial analysis of the reactivity of C57B1 females against isologous male skin grafts by KLEIN E. (1961)
MERRITT , K. , AND A. G. JOHNSON. 1964 . Enhancement of antibody formation with isologous nucleic acids . Federation Proc. 23 : 139 . / Federation Proc. / Enhancement of antibody formation with isologous nucleic acids by MERRITT K. (1964)
NELSON , E. 1957 . Enhanced antibody response in mice immunized with Bovine Serum Albumin (BSA) incorporated into particles made from hemoglobin . Federation Proc. 16 : 427 . / Federation Proc. / Enhanced antibody response in mice immunized with Bovine Serum Albumin (BSA) incorporated into particles made from hemoglobin by NELSON E. (1957)
NETER , E. 1956 . Bacterial hemagglutination and hemolysis . Bacteriol. Rev. 20 : 166 - 188 . (10.1128/br.20.3.166-188.1956) / Bacteriol. Rev. / Bacterial hemagglutination and hemolysis by NETER E. (1956)
NETER , E., H. Y. WHANG , T. SUZUKI , A ND E . A. GORZYNSKI. 1964 . Differences in antibody response of rabbit to intravenously injected soluble and cell-attached enterobacterial antigen . Immunology 7 : 657464 . / Immunology / Differences in antibody response of rabbit to intravenously injected soluble and cell-attached enterobacterial antigen by NETER E., H. (1964)
REED , L. J. , AND H. MUENCH. 1938 . A simple method of estimating fifty per cent endpoints . Am. J. Hyg. 27 : 493 - 497 . / Am. J. Hyg. / A simple method of estimating fifty per cent endpoints by REED L. J. (1938)
STETSON C. A. 1959. Endotoxins and bacterial allergy p. 442-450. In H. S. Lawrence [ed.] Cellular and humoral aspects of the hypersensitive states. Harper and Bros. New York.
STETSON C. A. 1964. Role of hypersensitivity in reactions to endotoxin p. 658-662. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J.
STINEBRING W. R. A. E. AXELROD AND A. C. TRAKATELLIS. 1964. Cellular and systemic reac- tivity to endotoxin and the relationship to tuberculin (PPD) hypersensitivity p. 455-459. In M. Landy and W. Braun [ed.] Bacterial en- dotoxins. Rutgers Univ. Press New Brunswick N.J.
THOMAS , L. 1954 . The physiological disturbances produced by endotoxins . Ann. Rev. Physiol. 16 : 467 - 490 . (10.1146/annurev.ph.16.030154.002343) / Ann. Rev. Physiol. / The physiological disturbances produced by endotoxins by THOMAS L. (1954)
WHITE , R. G. 1963 . Factors affecting the antibody response . Brit. Med. Bull. 192 : 207 - 213 . (10.1093/oxfordjournals.bmb.a070058) / Brit. Med. Bull. / Factors affecting the antibody response by WHITE R. G. (1963)

Dates

Type	When
Created	5 years, 7 months ago (Jan. 3, 2020, 4:36 p.m.)
Deposited	4 years, 1 month ago (July 29, 2021, 1:18 p.m.)
Indexed	4 months, 2 weeks ago (April 10, 2025, 10:12 a.m.)
Issued	59 years, 11 months ago (Sept. 1, 1965)
Published	59 years, 11 months ago (Sept. 1, 1965)
Published Print	59 years, 11 months ago (Sept. 1, 1965)

Funders 0

None

BibTeX

@article{Heppner_1965, title={High Susceptibility of Strain A Mice to Endotoxin and Endotoxin-Red Blood Cell Mixtures}, volume={90}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.90.3.696-703.1965}, DOI={10.1128/jb.90.3.696-703.1965}, number={3}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Heppner, Gloria and Weiss, David W.}, year={1965}, month=sep, pages={696–703} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        4,
        10
      ]
    ],
    "date-time": "2025-04-10T14:12:34Z",
    "timestamp": 1744294354879
  },
  "reference-count": 20,
  "publisher": "American Society for Microbiology",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1965,
            9,
            1
          ]
        ],
        "date-time": "1965-09-01T00:00:00Z",
        "timestamp": -136771200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://journals.asm.org/non-commercial-tdm-license"
    }
  ],
  "content-domain": {
    "domain": [
      "journals.asm.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1965,
        9
      ]
    ]
  },
  "abstract": "<jats:p>\n            <jats:sc>Heppner, Gloria</jats:sc>\n            (University of California, Berkeley),\n            <jats:sc>and David W. Weiss</jats:sc>\n            . High susceptibility of strain A mice to endotoxin and endotoxin-red blood cell mixtures. J. Bacteriol.\n            <jats:bold>90:</jats:bold>\n            696\u2013703. 1965.\u2014Strain A mice were shown to be considerably more susceptible to lethal effects of endotoxin lipopolysaccharide (LPS) than mice of several other strains. Complexes of sublethal quantities of LPS and sheep red blood cells were synergistically toxic for strain A mice. Separate administration of sheep red blood cells and heat-killed salmonellae, in either order and as long as 24 hr apart, also proved to be synergistically lethal for strain A mice, but not for R\n            <jats:sub>III</jats:sub>\n            animals studied comparatively. Sheep red blood cell lysates possessed the ability of the intact cells in forming lethal combinations for strain A mice with killed salmonellae. Strain A red blood cell-killed salmonellae complexes were also lethal for strain A mice, but less so then complexes made with sheep red blood cells. A \u00d7 R\n            <jats:sub>III</jats:sub>\n            F\n            <jats:sub>1</jats:sub>\n            hybrid animals showed the same resistance characteristics as the resistant R\n            <jats:sub>III</jats:sub>\n            parental strain. Possible explanations for these findings are suggested, and their relevance to an immunological mode of action of endotoxin lethality is discussed.\n          </jats:p>",
  "DOI": "10.1128/jb.90.3.696-703.1965",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2020,
        1,
        3
      ]
    ],
    "date-time": "2020-01-03T21:36:51Z",
    "timestamp": 1578087411000
  },
  "page": "696-703",
  "update-policy": "http://dx.doi.org/10.1128/asmj-crossmark-policy-page",
  "source": "Crossref",
  "is-referenced-by-count": 86,
  "title": "High Susceptibility of Strain A Mice to Endotoxin and Endotoxin-Red Blood Cell Mixtures",
  "prefix": "10.1128",
  "volume": "90",
  "author": [
    {
      "given": "Gloria",
      "family": "Heppner",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Bacteriology and Cancer Research Genetics Laboratory, University of California, Berkeley, California"
        }
      ]
    },
    {
      "given": "David W.",
      "family": "Weiss",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Bacteriology and Cancer Research Genetics Laboratory, University of California, Berkeley, California"
        }
      ]
    }
  ],
  "member": "235",
  "reference": [
    {
      "key": "p_1",
      "first-page": "216",
      "article-title": "Heterohemoantibodies and hemolysins in inbred strains of mice. II. Immune agglutinins and hemolysins for sheep and chicken red cells",
      "volume": "72",
      "author": "DAVIDSOHN I.",
      "year": "1954",
      "unstructured": "DAVIDSOHN , I. , AND K. STERN. 1954 . Heterohemoantibodies and hemolysins in inbred strains of mice. II. Immune agglutinins and hemolysins for sheep and chicken red cells . J. Immunol. 72 : 216 - 223 .",
      "journal-title": "J. Immunol."
    },
    {
      "key": "p_2",
      "doi-asserted-by": "crossref",
      "first-page": "252",
      "DOI": "10.3181/00379727-108-26906",
      "article-title": "The red blood cell: an essential component of the toxicity of strangulation intestinal obstruction",
      "volume": "108",
      "author": "DAVIS J. H.",
      "year": "1961",
      "unstructured": "DAVIS , J. H. , AND A. B. YULL. 1961 . The red blood cell: an essential component of the toxicity of strangulation intestinal obstruction . Proc. Soc. Exptl. Biol. Med. 108 : 252 - 253 .",
      "journal-title": "Proc. Soc. Exptl. Biol. Med."
    },
    {
      "key": "p_3",
      "unstructured": "FINE J. 1964. Some observations on the mechanism of action of bacterial endotoxin p. 588-595. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J."
    },
    {
      "key": "p_4",
      "unstructured": "FORBUS W. D. 1952. Reaction to injury p. 33. The Williams & Wilkins Co. Baltimore."
    },
    {
      "key": "p_5",
      "unstructured": "GLADSTONE G. P. 1962. Pathogenicity and virulence of microorganisms p. 746. In H. Florey [ed.] General pathology 3rd ed. W. B. Saunders Co. Philadelphia."
    },
    {
      "key": "p_6",
      "unstructured": "HEILMAN D. H. 1964. Cellular aspects of the action of endotoxin: the role of the macrophage p. 610-617. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J."
    },
    {
      "key": "p_7",
      "unstructured": "HILL G. J. AND D. W. WEISS. 1964. Relationships between susceptibility of mice to heat-killed salmonellae and endotoxin and the affinity of their red blood cells for killed organisms p. 422-427. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J."
    },
    {
      "key": "p_8",
      "unstructured": "JANOFF A. AND G. KALEY. 1964. Studies on Iysosomes in tolerance shock and local injury induced by endotoxin p. 631-647. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J."
    },
    {
      "key": "p_9",
      "unstructured": "JOHNSON A. G. 1964. Adjuvant action of bacterial endotoxins on the primary antibody response p. 256-262. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J."
    },
    {
      "key": "p_10",
      "doi-asserted-by": "crossref",
      "first-page": "457",
      "DOI": "10.1097/00006534-196104000-00043",
      "article-title": "Factorial analysis of the reactivity of C57B1 females against isologous male skin grafts",
      "volume": "27",
      "author": "KLEIN E.",
      "year": "1961",
      "unstructured": "KLEIN , E. , AND 0. LI NDER . 1961 . Factorial analysis of the reactivity of C57B1 females against isologous male skin grafts . Transplant Bull. 27 : 457 - 459 .",
      "journal-title": "Transplant Bull."
    },
    {
      "key": "p_11",
      "first-page": "139",
      "article-title": "Enhancement of antibody formation with isologous nucleic acids",
      "volume": "23",
      "author": "MERRITT K.",
      "year": "1964",
      "unstructured": "MERRITT , K. , AND A. G. JOHNSON. 1964 . Enhancement of antibody formation with isologous nucleic acids . Federation Proc. 23 : 139 .",
      "journal-title": "Federation Proc."
    },
    {
      "key": "p_12",
      "first-page": "427",
      "article-title": "Enhanced antibody response in mice immunized with Bovine Serum Albumin (BSA) incorporated into particles made from hemoglobin",
      "volume": "16",
      "author": "NELSON E.",
      "year": "1957",
      "unstructured": "NELSON , E. 1957 . Enhanced antibody response in mice immunized with Bovine Serum Albumin (BSA) incorporated into particles made from hemoglobin . Federation Proc. 16 : 427 .",
      "journal-title": "Federation Proc."
    },
    {
      "key": "p_13",
      "doi-asserted-by": "crossref",
      "first-page": "166",
      "DOI": "10.1128/br.20.3.166-188.1956",
      "article-title": "Bacterial hemagglutination and hemolysis",
      "volume": "20",
      "author": "NETER E.",
      "year": "1956",
      "unstructured": "NETER , E. 1956 . Bacterial hemagglutination and hemolysis . Bacteriol. Rev. 20 : 166 - 188 .",
      "journal-title": "Bacteriol. Rev."
    },
    {
      "key": "p_14",
      "first-page": "657464",
      "article-title": "Differences in antibody response of rabbit to intravenously injected soluble and cell-attached enterobacterial antigen",
      "volume": "7",
      "author": "NETER E., H.",
      "year": "1964",
      "unstructured": "NETER , E., H. Y. WHANG , T. SUZUKI , A ND E . A. GORZYNSKI. 1964 . Differences in antibody response of rabbit to intravenously injected soluble and cell-attached enterobacterial antigen . Immunology 7 : 657464 .",
      "journal-title": "Immunology"
    },
    {
      "key": "p_15",
      "first-page": "493",
      "article-title": "A simple method of estimating fifty per cent endpoints",
      "volume": "27",
      "author": "REED L. J.",
      "year": "1938",
      "unstructured": "REED , L. J. , AND H. MUENCH. 1938 . A simple method of estimating fifty per cent endpoints . Am. J. Hyg. 27 : 493 - 497 .",
      "journal-title": "Am. J. Hyg."
    },
    {
      "key": "p_16",
      "unstructured": "STETSON C. A. 1959. Endotoxins and bacterial allergy p. 442-450. In H. S. Lawrence [ed.] Cellular and humoral aspects of the hypersensitive states. Harper and Bros. New York."
    },
    {
      "key": "p_17",
      "unstructured": "STETSON C. A. 1964. Role of hypersensitivity in reactions to endotoxin p. 658-662. In M. Landy and W. Braun [ed.] Bacterial endotoxins. Rutgers Univ. Press New Brunswick N.J."
    },
    {
      "key": "p_18",
      "unstructured": "STINEBRING W. R. A. E. AXELROD AND A. C. TRAKATELLIS. 1964. Cellular and systemic reac- tivity to endotoxin and the relationship to tuberculin (PPD) hypersensitivity p. 455-459. In M. Landy and W. Braun [ed.] Bacterial en- dotoxins. Rutgers Univ. Press New Brunswick N.J."
    },
    {
      "key": "p_19",
      "doi-asserted-by": "crossref",
      "first-page": "467",
      "DOI": "10.1146/annurev.ph.16.030154.002343",
      "article-title": "The physiological disturbances produced by endotoxins",
      "volume": "16",
      "author": "THOMAS L.",
      "year": "1954",
      "unstructured": "THOMAS , L. 1954 . The physiological disturbances produced by endotoxins . Ann. Rev. Physiol. 16 : 467 - 490 .",
      "journal-title": "Ann. Rev. Physiol."
    },
    {
      "key": "p_20",
      "doi-asserted-by": "crossref",
      "first-page": "207",
      "DOI": "10.1093/oxfordjournals.bmb.a070058",
      "article-title": "Factors affecting the antibody response",
      "volume": "192",
      "author": "WHITE R. G.",
      "year": "1963",
      "unstructured": "WHITE , R. G. 1963 . Factors affecting the antibody response . Brit. Med. Bull. 192 : 207 - 213 .",
      "journal-title": "Brit. Med. Bull."
    }
  ],
  "container-title": "Journal of Bacteriology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.asm.org/doi/pdf/10.1128/jb.90.3.696-703.1965",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://journals.asm.org/doi/pdf/10.1128/jb.90.3.696-703.1965",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        7,
        29
      ]
    ],
    "date-time": "2021-07-29T17:18:54Z",
    "timestamp": 1627579134000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://journals.asm.org/doi/10.1128/jb.90.3.696-703.1965"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1965,
        9
      ]
    ]
  },
  "references-count": 20,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          1965,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1128/jb.90.3.696-703.1965"
  ],
  "URL": "http://dx.doi.org/10.1128/JB.90.3.696-703.1965",
  "relation": {},
  "ISSN": [
    "0021-9193",
    "1098-5530"
  ],
  "subject": [],
  "container-title-short": "J Bacteriol",
  "published": {
    "date-parts": [
      [
        1965,
        9
      ]
    ]
  },
  "assertion": [
    {
      "value": "2021-02-01",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}