DOI: 10.1128/jb.87.3.566-573.1964. REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE I

REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE I

10.1128/jb.87.3.566-573.1964

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

Ramakrishnan , T. (Yale University, New Haven, Conn.), and Edward A. Adelberg . Regulatory mechanisms in the biosynthesis of isoleucine and valine. I. Genetic derepression of enzyme formation. J. Bacteriol. 87: 566–573. 1964.—A total of 60 mutants of Escherichia coli K-12 resistant to 10 −2 m valine were isolated from the valine-sensitive F′ strain AB1206. Conjugation experiments showed that in five of these mutants the valine-resistance locus is closely linked to the structural genes governing isoleucine-valine biosynthesis. In these five valine-resistant mutants, three enzymes of the isoleucine-valine pathway were found to be coordinately derepressed: l -threonine deaminase, dihydroxy acid dehydrase, and transaminase B. Two other enzymes of this pathway, the condensing enzyme and the reductoisomerase, were unaffected. The mutation from valine-sensitivity to valine-resistance appears to have altered an operator locus, because the derepressed state is dominant over the repressed state in diploids heterozygous for the valine-resistance locus. The valine-resistant mutants excrete isoleucine into the medium. The significance of these findings with respect to the valine-sensitivity of E. coli K-12 and the regulation of the biosynthesis of isoleucine and valine by this organism are discussed.

Authors 2

T. Ramakrishnan (first)
Edward A. Adelberg (additional)

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Dates

Type	When
Created	5 years, 7 months ago (Jan. 3, 2020, 3:48 p.m.)
Deposited	4 years, 1 month ago (July 29, 2021, 1:14 p.m.)
Indexed	1 year, 1 month ago (July 30, 2024, 4:26 a.m.)
Issued	61 years, 6 months ago (March 1, 1964)
Published	61 years, 6 months ago (March 1, 1964)
Published Print	61 years, 6 months ago (March 1, 1964)

Funders 0

None

BibTeX

@article{Ramakrishnan_1964, title={REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE I: Genetic Derepression of Enzyme Formation}, volume={87}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.87.3.566-573.1964}, DOI={10.1128/jb.87.3.566-573.1964}, number={3}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Ramakrishnan, T. and Adelberg, Edward A.}, year={1964}, month=mar, pages={566–573} }

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