DOI: 10.1128/jb.186.13.4192-4198.2004. Dps Protects Cells against Multiple Stresses during Stationary Phase

Dps Protects Cells against Multiple Stresses during Stationary Phase

10.1128/jb.186.13.4192-4198.2004

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

ABSTRACTDps, the nonspecific DNA-binding protein from starved cells, is the most abundant protein in stationary-phaseEscherichia coli. Dps homologs are found throughout the bacteria and in at least one archaeal species. Dps has been shown to protect cells from oxidative stress during exponential-phase growth. During stationary phase, Dps organizes the chromosome into a highly ordered, stable nucleoprotein complex called the biocrystal. We show here that Dps is required for long-term stationary-phase viability under competitive conditions and thatdpsmutants have altered lag phases compared to wild-type cells. We also show that during stationary phase Dps protects the cell not only from oxidative stress but also from UV and gamma irradiation, iron and copper toxicity, thermal stress, and acid and base shock. The protective roles of Dps are most likely achieved through a combination of functions associated with the protein-DNA binding and chromosome compaction, metal chelation, ferroxidase activity, and regulation of gene expression.

Bibliography

Nair, S., & Finkel, S. E. (2004). Dps Protects Cells against Multiple Stresses during Stationary Phase. Journal of Bacteriology, 186(13), 4192â4198.

Authors 2

Sudha Nair (first)
Steven E. Finkel (additional)

References 29 Referenced 298

Dates

Type	When
Created	21 years, 2 months ago (June 17, 2004, 3:03 p.m.)
Deposited	2 years, 4 months ago (April 28, 2023, 5:36 p.m.)
Indexed	1 day, 3 hours ago (Aug. 31, 2025, 6:03 a.m.)
Issued	21 years, 2 months ago (July 1, 2004)
Published	21 years, 2 months ago (July 1, 2004)
Published Print	21 years, 2 months ago (July 1, 2004)

Funders 0

None

BibTeX

@article{Nair_2004, title={Dps Protects Cells against Multiple Stresses during Stationary Phase}, volume={186}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.186.13.4192-4198.2004}, DOI={10.1128/jb.186.13.4192-4198.2004}, number={13}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Nair, Sudha and Finkel, Steven E.}, year={2004}, month=jul, pages={4192–4198} }

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