Prokaryotic Utilization of the Twin-Arginine Translocation Pathway: a Genomic Survey
10.1128/jb.185.4.1478-1483.2003
Crossref journal-article
American Society for Microbiology
Journal of Bacteriology (235)
Abstract

ABSTRACT The twin-arginine translocation (Tat) pathway, which has been identified in plant chloroplasts and prokaryotes, allows for the secretion of folded proteins. However, the extent to which this pathway is used among the prokaryotes is not known. By using a genomic approach, a comprehensive list of putative Tat substrates for 84 diverse prokaryotes was established. Strikingly, the results indicate that the Tat pathway is utilized to highly varying extents. Furthermore, while many prokaryotes use this pathway predominantly for the secretion of redox proteins, analyses of the predicted substrates suggest that certain bacteria and archaea secrete mainly nonredox proteins via the Tat pathway. While no correlation was observed between the number of Tat machinery components encoded by an organism and the number of predicted Tat substrates, it was noted that the composition of this machinery was specific to phylogenetic taxa.

Bibliography

Dilks, K., Rose, R. W., Hartmann, E., & Pohlschröder, M. (2003). Prokaryotic Utilization of the Twin-Arginine Translocation Pathway: a Genomic Survey. Journal of Bacteriology, 185(4), 1478–1483.

Authors 4 University of Pennsylvania
  1. Kieran Dilks (first) University of Pennsylvania
  2. R. Wesley Rose (additional) University of Pennsylvania
  3. Enno Hartmann (additional)
  4. Mechthild Pohlschröder (additional) University of Pennsylvania
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Dates
Type When
Created 22 years, 7 months ago (Jan. 31, 2003, 3:03 p.m.)
Deposited 4 years, 1 month ago (July 29, 2021, 2:13 p.m.)
Indexed 1 month ago (Aug. 2, 2025, 12:57 a.m.)
Issued 22 years, 6 months ago (Feb. 15, 2003)
Published 22 years, 6 months ago (Feb. 15, 2003)
Published Print 22 years, 6 months ago (Feb. 15, 2003)
Funders 0

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@article{Dilks_2003, title={Prokaryotic Utilization of the Twin-Arginine Translocation Pathway: a Genomic Survey}, volume={185}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.185.4.1478-1483.2003}, DOI={10.1128/jb.185.4.1478-1483.2003}, number={4}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Dilks, Kieran and Rose, R. Wesley and Hartmann, Enno and Pohlschröder, Mechthild}, year={2003}, month=feb, pages={1478–1483} }