ABurkholderia pseudomalleiType III Secreted Protein, BopE, Facilitates Bacterial Invasion of Epithelial Cells and Exhibits Guanine Nucleotide Exchange Factor Activity
10.1128/jb.185.16.4992-4996.2003
Crossref journal-article
American Society for Microbiology
Journal of Bacteriology (235)
Abstract

ABSTRACTWe report the characterization of BopE, a type III secreted protein that is encoded adjacent to theBurkholderia pseudomallei bsalocus and is homologous toSalmonellaentericaSopE/SopE2. Inactivation ofbopEimpaired bacterial entry into HeLa cells, indicating that BopE facilitates invasion. Consistent with this notion, BopE expressed in eukaryotic cells induced rearrangements in the subcortical actin cytoskeleton, and purified BopE exhibited guanine nucleotide exchange factor activity for Cdc42 and Rac1 in vitro.

Bibliography

Stevens, M. P., Friebel, A., Taylor, L. A., Wood, M. W., Brown, P. J., Hardt, W.-D., & Galyov, E. E. (2003). ABurkholderia pseudomalleiType III Secreted Protein, BopE, Facilitates Bacterial Invasion of Epithelial Cells and Exhibits Guanine Nucleotide Exchange Factor Activity. Journal of Bacteriology, 185(16), 4992–4996.

Authors 7
  1. Mark P. Stevens (first)
  2. Andrea Friebel (additional)
  3. Lowrie A. Taylor (additional)
  4. Michael W. Wood (additional)
  5. Philip J. Brown (additional)
  6. Wolf-Dietrich Hardt (additional)
  7. Edouard E. Galyov (additional)
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Dates
Type When
Created 22 years ago (Aug. 1, 2003, 7:08 p.m.)
Deposited 1 year, 7 months ago (Jan. 10, 2024, 6:19 a.m.)
Indexed 2 months ago (June 26, 2025, 9:29 a.m.)
Issued 22 years ago (Aug. 15, 2003)
Published 22 years ago (Aug. 15, 2003)
Published Print 22 years ago (Aug. 15, 2003)
Funders 0

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@article{Stevens_2003, title={ABurkholderia pseudomalleiType III Secreted Protein, BopE, Facilitates Bacterial Invasion of Epithelial Cells and Exhibits Guanine Nucleotide Exchange Factor Activity}, volume={185}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.185.16.4992-4996.2003}, DOI={10.1128/jb.185.16.4992-4996.2003}, number={16}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Stevens, Mark P. and Friebel, Andrea and Taylor, Lowrie A. and Wood, Michael W. and Brown, Philip J. and Hardt, Wolf-Dietrich and Galyov, Edouard E.}, year={2003}, month=aug, pages={4992–4996} }