DOI: 10.1128/jb.139.3.866-876.1979. Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants

Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants

10.1128/jb.139.3.866-876.1979

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

Dominant mutations at two newly identified loci, designated SRS1 and SRS2, that metabolically suppress the trimethoprim sensitivity of rad6 and rad18 strains, have been isolated from trimethoprim-resistant mutants arising spontaneously in rad6-1 rad18-2 strains of the yeast Saccharomyces cerevisiae. The SRS2 mutations also efficiently suppress the ultraviolet light sensitivity of the parent strains. They do not, however, suppress their sensitivity to ionizing radiation or their deficiency with respect to induced mutagenesis and sporulation. Such observations support the hypothesis that RAD6-dependent activities can be separated into two functionally distinct groups: a group of error-free repair activities that are responsible for a large amount of the radiation resistance of wild-type strains and also for their resistance to trimethoprim, and a group of error-prone activities that are responsible for induced mutagenesis and are also important in sporulation, but which account at best for only a very small amount of wild-type recovery.

Bibliography

Lawrence, C. W., & Christensen, R. B. (1979). Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants. Journal of Bacteriology, 139(3), 866â876.

Authors 2

C W Lawrence (first)
R B Christensen (additional)

References 20 Referenced 122

Chlebowicz , E. , and W. J. Jachymczyk . 1979 . Repair of MMS-induced DNA double-strand breaks in haploid cells of Saccharomyces cerevisiae, which requires the presence of a duplicate genome . Mol. Gen. Genet. 167 : 279 - 286 . (10.1007/BF00267420) / Mol. Gen. Genet. / Repair of MMS-induced DNA double-strand breaks in haploid cells of Saccharomyces cerevisiae, which requires the presence of a duplicate genome by Chlebowicz E. (1979)
Clark A. J. and M. R. Volkert. 1978. A new classification of pathways repairing pyrimidine dimer damage in DNA p. 57-72. In P. C. Hanawalt E. C. Friedberg and C. F. Fox (ed.) DNA repair mechanisms. Academic Press Inc. New York. (10.1016/B978-0-12-322650-1.50014-X)
Cox , B. S. , and J. C. Game . 1974 . Repair systems in Saccharomyces cerevisiae . Mutat. Res. 26 : 257 - 264 . (10.1016/S0027-5107(74)80023-0) / Mutat. Res. / Repair systems in Saccharomyces cerevisiae by Cox B. S. (1974)
Cox , B. S. , and J. M. Parry . 1968 . The isolation, genetics and survival characteristics of ultraviolet light-sensitive mutants in yeast . Mutat. Res. 6 : 37 - 55 . (10.1016/0027-5107(68)90101-2) / Mutat. Res. / The isolation, genetics and survival characteristics of ultraviolet light-sensitive mutants in yeast by Cox B. S. (1968)
Game , J. C. , J. G. Little , and R. H. Haynes . 1975 . Yeast mutants sensitive to trimethoprim . Mutat. Res. 28 : 175 - 182 . (10.1016/0027-5107(75)90094-9) / Mutat. Res. / Yeast mutants sensitive to trimethoprim by Game J. C. (1975)
Game , J. C. , and R. K. Mortimer . 1974 . A genetic study of X-ray sensitive mutants in yeast . Mutat. Res. 24 : 281 - 292 . (10.1016/0027-5107(74)90176-6) / Mutat. Res. / A genetic study of X-ray sensitive mutants in yeast by Game J. C. (1974)
Hastings , P. J. , S. -K. Quah , and R. C. vonBorstel . 1976 . Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA . Nature (London) 264 : 719 - 722 . (10.1038/264719a0) / Nature (London) / Spontaneous mutation by mutagenic repair of spontaneous lesions in DNA by Hastings P. J. (1976)
Hawthorne , D. C. , and V. Leupold . 1974 . Suppressors in yeast . Curr. Top. Microbiol. Immunol. 64 : 1 - 47 . (10.1007/978-3-642-65848-8_1) / Curr. Top. Microbiol. Immunol. / Suppressors in yeast by Hawthorne D. C. (1974)
Hunnable , E. G. , and B. S. Cox . 1971 . The genetic control of dark recombination in yeast . Mutat. Res. 13 : 297 - 309 . (10.1016/0027-5107(71)90040-6) / Mutat. Res. / The genetic control of dark recombination in yeast by Hunnable E. G. (1971)
Jachymczyk , W. J. , E. Chelbowicz , Z. Swietlinska , and J. Zuk . 1977 . Alkaline sucrose sedimentation studies of MMS-induced DNA single-strand breakage and rejoining in the wild type and in UV-sensitive mutants of Saccharomvces cerei,siae . Mutat. Res. 43 : 1 - 10 . (10.1016/0027-5107(77)90126-9) / Mutat. Res. / Alkaline sucrose sedimentation studies of MMS-induced DNA single-strand breakage and rejoining in the wild type and in UV-sensitive mutants of Saccharomvces cerei,siae by Jachymczyk W. J. (1977)
Kern , R. , and F. K. Zimmermann . 1978 . The influence of defects in excision and error-prone repair on spontaneous and induced mitotic recombination and mutation in Saccharomvces (erel'isiae . Mol. Gen. Genet. 161 : 81 - 88 . (10.1007/BF00266618) / Mol. Gen. Genet. / The influence of defects in excision and error-prone repair on spontaneous and induced mitotic recombination and mutation in Saccharomvces (erel'isiae by Kern R. (1978)
Lawrence , C. W. , and R. B. Christensen . 1976 . UJV mutagenesis in radiation-sensitive strains of yeast . Genetics 82 : 207 - 232 . (10.1093/genetics/82.2.207) / Genetics / UJV mutagenesis in radiation-sensitive strains of yeast by Lawrence C. W. (1976)
Lawrence , C. W. , and R. B. Christensen . 1978 . Ultraviolet-induced reversion of cvcl alleles in radiation-sensitive strains of yeast. I. ret!i mutant strains . J. Mol. Biol. 122 : 1 - 21 . (10.1016/0022-2836(78)90104-3) / J. Mol. Biol. / Ultraviolet-induced reversion of cvcl alleles in radiation-sensitive strains of yeast. I. ret!i mutant strains by Lawrence C. W. (1978)
Lawrence , C. W. , and R. B. Christensen . 1978 . Ultraviolet-induced reversion of cvel alleles in radiation-sensitive strains of yeast. II. ret,2 mutant strains . Genetics 90 : 213 - 226 . (10.1093/genetics/90.2.213) / Genetics / Ultraviolet-induced reversion of cvel alleles in radiation-sensitive strains of yeast. II. ret,2 mutant strains by Lawrence C. W. (1978)
Lawrence , C. W. , J. W. Stewart , F. Sherman , and R. Christensen . 1974 . Specificity and frequency of ultraviolet-induced reversion on an iso- 1-cytochrome c ochre mutant in radiation-sensitive strains of yeast. .1 . Mol. Biol. 85 : 137 - 162 . (10.1016/0022-2836(74)90134-X) / Mol. Biol. / Specificity and frequency of ultraviolet-induced reversion on an iso- 1-cytochrome c ochre mutant in radiation-sensitive strains of yeast. .1 by Lawrence C. W. (1974)
Lea , D. E. , and C. A. Coulson . 1949 . The distribution of the numbers of mutants in bacterial populations . J. Genet. 49 : 264 - 285 . (10.1007/BF02986080) / J. Genet. / The distribution of the numbers of mutants in bacterial populations by Lea D. E. (1949)
Prakash , L. 1974 . Lack of chemically induced mutation in repair-deficient mutants of yeast . Genetics 78 : 1101 - 1118 . (10.1093/genetics/78.4.1101) / Genetics / Lack of chemically induced mutation in repair-deficient mutants of yeast by Prakash L. (1974)
Prakash , L. 1977 . Repair of pyrimidine dimers in radiation-sensitive mutants rad 3, rad 4, rad 6 and rad 9 of Saccharomyces cerel'isiae . Mutat. Res. 45 : 13 - 20 . (10.1016/0027-5107(77)90038-0) / Mutat. Res. / Repair of pyrimidine dimers in radiation-sensitive mutants rad 3, rad 4, rad 6 and rad 9 of Saccharomyces cerel'isiae by Prakash L. (1977)
Resnick , M. A. 1969 . Genetic control of radiation sensitivity in Saccharomyces cerevisiae . Genetics 62 : 519 - 531 . (10.1093/genetics/62.3.519) / Genetics / Genetic control of radiation sensitivity in Saccharomyces cerevisiae by Resnick M. A. (1969)
vonBorstel , R. C. , K. T. Cain , and C. M. Steinberg . 1971 . Inheritance of spontaneous mutability in yeast . Genetics 69 : 17 - 27 . (10.1093/genetics/69.1.17) / Genetics / Inheritance of spontaneous mutability in yeast by vonBorstel R. C. (1971)

Dates

Type	When
Created	5 years, 7 months ago (Jan. 3, 2020, 11:36 a.m.)
Deposited	1 year, 11 months ago (Sept. 24, 2023, 1:43 p.m.)
Indexed	4 months, 2 weeks ago (April 7, 2025, 5:48 p.m.)
Issued	45 years, 11 months ago (Sept. 1, 1979)
Published	45 years, 11 months ago (Sept. 1, 1979)
Published Print	45 years, 11 months ago (Sept. 1, 1979)

Funders 0

None

BibTeX

@article{Lawrence_1979, title={Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants}, volume={139}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.139.3.866-876.1979}, DOI={10.1128/jb.139.3.866-876.1979}, number={3}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Lawrence, C W and Christensen, R B}, year={1979}, month=sep, pages={866–876} }

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  "assertion": [
    {
      "value": "2021-02-02",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}