DOI: 10.1128/jb.126.3.1173-1179.1976. Compartmentation and control of arginine metabolism in Neurospora

Compartmentation and control of arginine metabolism in Neurospora

10.1128/jb.126.3.1173-1179.1976

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

The fate of [14-C]arginine derived from the medium or from biosynthesis has been examined in Neurospora growing in arginine-supplemented medium. In both cases the label enters the cytosol, where it is used efficiently for both protein synthesis and catabolism before mixing with the majority of the endogenous [12C]arginine pool. Both metabolic processes appear to use the same cytosolic arginine pool. It is calculated that the nonorganellar cytoplasm contains approximately 20% of the intracellular arginine pool when the cells are growing in arginine-supplemented medium. The results suggest that compartmentation of arginine is a significant factor in controlling arginine metabolism in Neurospora. The significance of these results for studies of amino acid metabolism in other eukaryotic systems is discussed.

Bibliography

Weiss, R. L. (1976). Compartmentation and control of arginine metabolism in Neurospora. Journal of Bacteriology, 126(3), 1173â1179.

Authors 1

R L Weiss (first)

References 21 Referenced 46

Barthelmess , I. B. , C. F. Curtis , and H. Kacser . 1974 . Control of the flux to arginine in Neurospora crassa: de-repression of the last three enzymes of the arginine pathway . J. Mol. Biol. 87 : 303 - 316 . (10.1016/0022-2836(74)90151-X) / J. Mol. Biol. / Control of the flux to arginine in Neurospora crassa: de-repression of the last three enzymes of the arginine pathway by Barthelmess I. B. (1974)
Casaneda , M. , J. Martuscelli , and J. Mora . 1967 . The catabolism of L-arginine by Neurospora crassa . Biochim. Biophys. Acta 141 : 276 - 286 . (10.1016/0304-4165(67)90102-X) / Biochim. Biophys. Acta / The catabolism of L-arginine by Neurospora crassa by Casaneda M. (1967)
Crokaert , R. , and E. Schram . 1958 . Dosage des Ncarbamoyl-deriv 4s d'acides amines par la diacetylmonoximb . Bull. Soc. Chim. Biol. 40 : 1093 - 1106 . / Bull. Soc. Chim. Biol. / Dosage des Ncarbamoyl-deriv 4s d'acides amines par la diacetylmonoximb by Crokaert R. (1958)
Cybis , J. J. , and R. H. Davis . 1975 . Acetylglutamate kinase: a feedback-sensitive enzyme of arginine biosynthesis in Neurospora . Biochem. Biophys. Res. Commun. 60 : 629 - 634 . (10.1016/0006-291X(74)90287-3) / Biochem. Biophys. Res. Commun. / Acetylglutamate kinase: a feedback-sensitive enzyme of arginine biosynthesis in Neurospora by Cybis J. J. (1975)
Cybis , J. , and R. H. Davis . 1975 . Organization and control in the arginine biosynthetic pathway of Neurospora . J. Bacteriol. 123 : 196 - 202 . (10.1128/jb.123.1.196-202.1975) / J. Bacteriol. / Organization and control in the arginine biosynthetic pathway of Neurospora by Cybis J. (1975)
Davis , R. H. 1970 . Sources of urea in Neurospora. Biochim. Biophys. Acta 215 : 412 - 414 . (10.1016/0304-4165(70)90042-5) / Neurospora. Biochim. Biophys. Acta / Sources of urea by Davis R. H. (1970)
Davis , R. H. , and F. J. de Serres . 1970 . Genetic and microbiological research techniques for Neurospora crassa . Methods Enzymol. 17A : 79 - 143 . (10.1016/0076-6879(71)17168-6) / Methods Enzymol. / Genetic and microbiological research techniques for Neurospora crassa by Davis R. H. (1970)
Davis , R. H. , M. B. Lawless , and L. A. Port . 1970 . Arginaseless Neurospora: genetics, physiology, and polyamine synthesis . J. Bacteriol. 102 : 299 - 305 . (10.1128/jb.102.2.299-305.1970) / J. Bacteriol. / Arginaseless Neurospora: genetics, physiology, and polyamine synthesis by Davis R. H. (1970)
Hendler , R. W. 1962 . A model for protein synthesis . Nature (London) 193 : 821 - 823 . (10.1038/193821a0) / Nature (London) / A model for protein synthesis by Hendler R. W. (1962)
Kolmark , H. G. 1969 . Genetic studies ofurease mutants in Neurospora crassa . Mutat. Res. 8 : 51 - 63 . (10.1016/0027-5107(69)90140-7) / Mutat. Res. / Genetic studies ofurease mutants in Neurospora crassa by Kolmark H. G. (1969)
Koritz , S. B. , and P. P. Cohen . 1954 . Colorimetric determination of carbamyl amino acids and related compounds . J. Biol. Chem. 209 : 145 - 150 . (10.1016/S0021-9258(18)65539-5) / J. Biol. Chem. / Colorimetric determination of carbamyl amino acids and related compounds by Koritz S. B. (1954)
Mortimore , G. E. , K. H. Woodslde , and J. E. Henry . 1972 . Compartmentation of free valine and its relation to protein turnover in perfused rat liver . J. Biol. Chem. 247 : 2776 - 2784 . (10.1016/S0021-9258(19)45279-4) / J. Biol. Chem. / Compartmentation of free valine and its relation to protein turnover in perfused rat liver by Mortimore G. E. (1972)
Oaks , A. , and R. G. S. Bidwell . 1970 . Compartmentation of intermediary metabolites. Annu . Rev. Plant Physiol. 21 : 43 - 66 . (10.1146/annurev.pp.21.060170.000355) / Rev. Plant Physiol. / Compartmentation of intermediary metabolites. Annu by Oaks A. (1970)
Slayman , C. W. , and E. L. Tatum . 1964 . Potassium transport in Neurospora. I. Intracellular sodium and potassium concentrations and cation requirements for growth . Biochim. Biophys. Acta 88 : 578 - 592 . / Biochim. Biophys. Acta / Potassium transport in Neurospora. I. Intracellular sodium and potassium concentrations and cation requirements for growth by Slayman C. W. (1964)
Srere , P. A. , and K. Mosbach . 1974 . Metabolic compartmentation: symbiotic, organellar, multienzymic, and microenvironmental. Annu . Rev. Microbiol. 28 : 61 - 84 . (10.1146/annurev.mi.28.100174.000425) / Rev. Microbiol. / Metabolic compartmentation: symbiotic, organellar, multienzymic, and microenvironmental. Annu by Srere P. A. (1974)
Subramanian , K. N. , R. L. Weiss , and R. H. Davis . 1973 . Use of external, biosynthetic, and organellar arginine by Neurospora . J. Bacteriol. 115 : 284 - 290 . (10.1128/jb.115.1.284-290.1973) / J. Bacteriol. / Use of external, biosynthetic, and organellar arginine by Neurospora by Subramanian K. N. (1973)
Thwaites , W. M. , and L. Pendyala . 1969 . Regulation of amino acid assimilation in a strain of Neurospora crassa lacking basic amino acid transport activity . Biochim. Biophys. Acta 192 : 455 - 461 . (10.1016/0304-4165(69)90394-8) / Biochim. Biophys. Acta / Regulation of amino acid assimilation in a strain of Neurospora crassa lacking basic amino acid transport activity by Thwaites W. M. (1969)
Weiss , R. L. 1973 . Intracellular localization ofornithine and arginine pools in Neurospora . J. Biol. Chem. 248 : 5409 - 5413 . (10.1016/S0021-9258(19)43616-8) / J. Biol. Chem. / Intracellular localization ofornithine and arginine pools in Neurospora by Weiss R. L. (1973)
Weiss , R. L. , and R. H. Davis . 1973 . Intracellular localization of enzymes of arginine metabolism in Neurospora . J. Biol. Chem. 248 : 5403 - 5408 . (10.1016/S0021-9258(19)43615-6) / J. Biol. Chem. / Intracellular localization of enzymes of arginine metabolism in Neurospora by Weiss R. L. (1973)
Van Pilsum , J. F. , R. P. Martin , E. Kito , and J. Hess . 1956 . Determination of creatine, creatinine, arginine, guanidoacetic acid, guanidine and methylguanidine in biological fluids . J. Biol. Chem. 222 : 225 - 236 . (10.1016/S0021-9258(19)50788-8) / J. Biol. Chem. / Determination of creatine, creatinine, arginine, guanidoacetic acid, guanidine and methylguanidine in biological fluids by Van Pilsum J. F. (1956)
Vogel , H. J. 1964 . Distribution of Iysine pathways among fungi: evolutionary implications . Am. Nat. 98 : 435 - 446 . (10.1086/282338) / Am. Nat. / Distribution of Iysine pathways among fungi: evolutionary implications by Vogel H. J. (1964)

Dates

Type	When
Created	5 years, 7 months ago (Jan. 3, 2020, 11:03 a.m.)
Deposited	4 years, 2 months ago (June 12, 2021, 8:49 a.m.)
Indexed	1 year, 10 months ago (Nov. 1, 2023, 1:40 p.m.)
Issued	49 years, 3 months ago (June 1, 1976)
Published	49 years, 3 months ago (June 1, 1976)
Published Print	49 years, 3 months ago (June 1, 1976)

Funders 0

None

BibTeX

@article{Weiss_1976, title={Compartmentation and control of arginine metabolism in Neurospora}, volume={126}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.126.3.1173-1179.1976}, DOI={10.1128/jb.126.3.1173-1179.1976}, number={3}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Weiss, R L}, year={1976}, month=jun, pages={1173–1179} }

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  "relation": {},
  "ISSN": [
    "0021-9193",
    "1098-5530"
  ],
  "subject": [],
  "container-title-short": "J Bacteriol",
  "published": {
    "date-parts": [
      [
        1976,
        6
      ]
    ]
  },
  "assertion": [
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      "value": "2021-02-02",
      "order": 2,
      "name": "published",
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    }
  ]
}