DOI: 10.1128/jb.116.2.818-822.1973. Modification of Ribosomes in Cryptopleurine-Resistant Mutants of Yeast

Modification of Ribosomes in Cryptopleurine-Resistant Mutants of Yeast

10.1128/jb.116.2.818-822.1973

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

Cryptopleurine-resistant mutants of Saccharomyces cerevisiae were isolated. A single, recessive nuclear gene, very closely linked to the mating locus (2.1 centimorgans), is responsible for resistance. Ribosomes from the mutants were found to be resistant to cryptopleurine when analyzed by poly(U)-directed polyphenylalanine synthesis. Analysis of the distribution of ribosomes between monosomes and polysomes in sensitive cells exposed to cryptopleurine suggests that some step is inhibited during the elongation phase of protein synthesis.

Bibliography

Skogerson, L., McLaughlin, C., & Wakatama, E. (1973). Modification of Ribosomes in Cryptopleurine-Resistant Mutants of Yeast. Journal of Bacteriology, 116(2), 818â822.

Authors 3

Lawrence Skogerson (first)
Calvin McLaughlin (additional)
Eunice Wakatama (additional)

References 14 Referenced 53

Battaner , E. , and D. Vazquez . 1971 . Inhibitors of protein synthesis by ribosomes of the 80 S type . Biochim. Biophys. Acta. 254 : 316 - 330 . (10.1016/0005-2787(71)90840-9) / Biochim. Biophys. Acta. / Inhibitors of protein synthesis by ribosomes of the 80 S type by Battaner E. (1971)
Bradsher , C. K. , and H. Berger . 1958 . Aromatic cyclodehydration. XXXUL. The synthesis of ( + ) -cryptopleurine . J. Amer. Chem. Soc. 80 : 930 - 932 . (10.1021/ja01537a044) / J. Amer. Chem. Soc. / Aromatic cyclodehydration. XXXUL. The synthesis of ( + ) -cryptopleurine by Bradsher C. K. (1958)
Donaldson , G. R. , M. R. Atkinson , and A. W. Murray . 1968 . Inhibition of protein synthesis in Ehrlich ascitestumor cells by the phenanthrene alkaloids tylophorine, tylocrebrine, and cryptopleurine . Biochem. Biophys. Res. Commun. 31 : 104 - 109 . (10.1016/0006-291X(68)90037-5) / Biochem. Biophys. Res. Commun. / Inhibition of protein synthesis in Ehrlich ascitestumor cells by the phenanthrene alkaloids tylophorine, tylocrebrine, and cryptopleurine by Donaldson G. R. (1968)
Fink G. R. 1970. The biochemical genetics of yeast p. 59-78. In H. Tabor and C. Tabor (ed.) Methods in enzymology vol. 17. Academic Press Inc. New York. (10.1016/0076-6879(71)17167-4)
Fridrichsons , J. , and A. Mc L. Mathieson . 1954 . Structure of a derivative of cryptopleurine . Nature (London) 173 : 732 - 733 . (10.1038/173732a0) / Nature (London) / Structure of a derivative of cryptopleurine by Fridrichsons J. (1954)
Gordon , J. 1969 . Hydrolysis of guanosine 5'-triphosphate associated with binding of aminoacyl transfer ribonucleic acid to ribosomes . J. Biol. Chem. 244 : 5680 - 5686 . (10.1016/S0021-9258(18)63613-0) / J. Biol. Chem. / Hydrolysis of guanosine 5'-triphosphate associated with binding of aminoacyl transfer ribonucleic acid to ribosomes by Gordon J. (1969)
Hartwell L. 1967. Macromolecule synthesis in temperature-sensitive mutants of yeast. J. Bacteriol; 93:1662-1670. (10.1128/jb.93.5.1662-1670.1967)
Hartwell , L. , and C. S. McLaughlin . 1968 . Temperaturesensitive mutants of yeast exhibiting a rapid inhibition of protein synthesis . J. Bacteriol. 96 : 1664 - 1671 . (10.1128/jb.96.5.1664-1671.1968) / J. Bacteriol. / Temperaturesensitive mutants of yeast exhibiting a rapid inhibition of protein synthesis by Hartwell L. (1968)
Haslam , J. M. , P. J. Davey , A. W. Linnane , and M. R. Atkinson . 1968 . Differentiation in vitro by phenanthrene alkaloids of yeast mitochondrial protein synthesis from ribosomal systems of both yeast and bacteria . Biochem. Biophys. Res. Commun. 33 : 368 - 373 . (10.1016/0006-291X(68)90579-2) / Biochem. Biophys. Res. Commun. / Differentiation in vitro by phenanthrene alkaloids of yeast mitochondrial protein synthesis from ribosomal systems of both yeast and bacteria by Haslam J. M. (1968)
Huang , M. - T. , and A. P. Grollman . 1972 . Mode of action of tylocrebrine: Effects on protein and nucleic acid synthesis . Mol. Pharmacol. 8 : 538 - 550 . / Mol. Pharmacol. / Mode of action of tylocrebrine: Effects on protein and nucleic acid synthesis by Huang M. (1972)
Mortimer , R. K. , and D. C. Hawthorne . 1966 . Genetic mapping in Saccharomyces . Genetics. 53 : 165 - 173 . (10.1093/genetics/53.1.165) / Genetics. / Genetic mapping in Saccharomyces by Mortimer R. K. (1966)
Pestka , S. , H. Rosenfeld , R. Harris , and H. Hintikka . 1972 . Studies on transfer ribonucleic acid-ribosome complexes. XXI. Effect of antibiotics on peptidylpuromycin synthesis by mammalian polysomes . J. Biol. Chem. 247 : 6895 . (10.1016/S0021-9258(19)44669-3) / J. Biol. Chem. / Studies on transfer ribonucleic acid-ribosome complexes. XXI. Effect of antibiotics on peptidylpuromycin synthesis by mammalian polysomes by Pestka S. (1972)
Pomper , S. , and P. R. Burkholder . 1949 . Studies on the biochemical genetics of yeast . Proc. Nat. Acad. Sci. U.S.A. 35 : 456 - 464 . (10.1073/pnas.35.8.456) / Proc. Nat. Acad. Sci. U.S.A. / Studies on the biochemical genetics of yeast by Pomper S. (1949)
Richter , D. 1970 . Formation of a ternary complex between yeast aminoacyl-tRNA binding factor, GTP, and aminoacyl-tRNA . Biochem. Biophys. Res. Commun. 38 : 864 - 870 . (10.1016/0006-291X(70)90800-4) / Biochem. Biophys. Res. Commun. / Formation of a ternary complex between yeast aminoacyl-tRNA binding factor, GTP, and aminoacyl-tRNA by Richter D. (1970)

Dates

Type	When
Created	5 years, 7 months ago (Jan. 3, 2020, 9:53 a.m.)
Deposited	4 years, 1 month ago (July 29, 2021, 1:11 p.m.)
Indexed	1 year, 9 months ago (Nov. 23, 2023, 11:43 a.m.)
Issued	51 years, 9 months ago (Nov. 1, 1973)
Published	51 years, 9 months ago (Nov. 1, 1973)
Published Print	51 years, 9 months ago (Nov. 1, 1973)

Funders 0

None

BibTeX

@article{Skogerson_1973, title={Modification of Ribosomes in Cryptopleurine-Resistant Mutants of Yeast}, volume={116}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.116.2.818-822.1973}, DOI={10.1128/jb.116.2.818-822.1973}, number={2}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Skogerson, Lawrence and McLaughlin, Calvin and Wakatama, Eunice}, year={1973}, month=nov, pages={818–822} }

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