DOI: 10.1128/jb.115.1.188-197.1973. Histidyl-Transfer Ribonucleic Acid Synthetase Mutants Requiring a High Internal Pool of Histidine for Growth

Histidyl-Transfer Ribonucleic Acid Synthetase Mutants Requiring a High Internal Pool of Histidine for Growth

10.1128/jb.115.1.188-197.1973

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

Mutants that require histidine due to an altered structural gene for the histidyl-transfer ribonucleic acid synthetase ( hisS ) have been isolated by a general selection for histidine-requiring strains in which the mutation producing histidine auxotrophy is unlinked to the histidine operon. One of the mutants has been shown to require an abnormally high internal histidine pool for growth owing to an altered synthetase that is unstable at low histidine concentrations. It is difficult to determine accurately the K m for histidine of the synthetase enzyme from the mutant because of the instability of the enzyme at limiting histidine concentrations; however, a histidine K m value has been estimated that is approximately 100 times higher than the histidine K m of the wild-type enzyme. For the mutant strains to achieve the high internal pool of histidine required for growth, all the systems that transport histidine from the growth medium must be functioning to capacity. Amino acids that interfere with histidine transport strongly inhibit the growth of the mutants. The mutants have been useful in providing a selective genetic marker for transductional mapping in the hisS region. The mutants are discussed as representative of a general class of curable mutants that have an altered enzyme with poor affinity for a substrate or coenzyme.

Bibliography

Straus, D. S., & Ames, B. N. (1973). Histidyl-Transfer Ribonucleic Acid Synthetase Mutants Requiring a High Internal Pool of Histidine for Growth. Journal of Bacteriology, 115(1), 188â197.

Authors 2

Daniel S. Straus (first)
Bruce N. Ames (additional)

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Dates

Type	When
Created	5 years, 7 months ago (Jan. 3, 2020, 9:52 a.m.)
Deposited	4 years ago (July 29, 2021, 1:08 p.m.)
Indexed	1 year, 9 months ago (Nov. 12, 2023, 1:29 a.m.)
Issued	52 years, 1 month ago (July 1, 1973)
Published	52 years, 1 month ago (July 1, 1973)
Published Print	52 years, 1 month ago (July 1, 1973)

Funders 0

None

BibTeX

@article{Straus_1973, title={Histidyl-Transfer Ribonucleic Acid Synthetase Mutants Requiring a High Internal Pool of Histidine for Growth}, volume={115}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.115.1.188-197.1973}, DOI={10.1128/jb.115.1.188-197.1973}, number={1}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Straus, Daniel S. and Ames, Bruce N.}, year={1973}, month=jul, pages={188–197} }

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