DOI: 10.1128/iai.70.12.7042-7049.2002. Effect of Trimethoprim-Sulfamethoxazole on Recurrent Bacteriuria and Bacterial Persistence in Mice Infected with Uropathogenic <i>Escherichia coli</i>

Effect of Trimethoprim-Sulfamethoxazole on Recurrent Bacteriuria and Bacterial Persistence in Mice Infected with Uropathogenic Escherichia coli

10.1128/iai.70.12.7042-7049.2002

Crossref journal-article

American Society for Microbiology

Infection and Immunity (235)

Abstract

ABSTRACT One of the more perplexing aspects of urinary tract infections (UTIs) is their high propensity to recur. It has been proposed that recurrent infections are a result of the reintroduction of bacteria from the gastrointestinal tract (GIT) to the urinary tract (UT); however, since a significant subset of recurrent UTIs are caused by an identical bacterial strain, it has been challenging to formally prove this hypothesis for same-strain recurrences by using epidemiologic approaches. We present data here obtained by using a mouse model of UTIs in which it was shown that 36% (5 of 14) of mice infected with uropathogenic Escherichia coli (UPEC) will have at least one bacteriuric recurrence, with 21% (3 of 14) having more than one recurrence during a 6-week period after an acute UTI. Intraurethrally infected mice develop UPEC reservoirs in both their feces and their bladders. Ten days of trimethoprim-sulfamethoxazole (SXT) therapy reduces urinary recurrences and eradicates fecal colonization, whereas 3 days of SXT treatment has no effect over a twenty-eight-day observation period despite clearing fecal colonization acutely. Interestingly, SXT is unable to eradicate bacteria from the bladder reservoir even after a 10-day treatment regimen, thus demonstrating that the bladder reservoir can persist even in the face of long-term antibiotic therapy.

Bibliography

Schilling, J. D., Lorenz, R. G., & Hultgren, S. J. (2002). Effect of Trimethoprim-Sulfamethoxazole on Recurrent Bacteriuria and Bacterial Persistence in Mice Infected with Uropathogenic Escherichia coli. Infection and Immunity, 70(12), 7042â7049.

Authors 3

Joel D. Schilling (first)
Robin G. Lorenz (additional)
Scott J. Hultgren (additional)

References 25 Referenced 129

Brauner, A., S. H. Jacobson, and I. Kuhn. 1992. Urinary Escherichia coli causing recurrent infections: a prospective follow-up of biochemical phenotypes. Clin. Nephrol.38:318-323. / Clin. Nephrol. (1992)
Cass A. S. and G. W. Ireland. 1985. Antibacterial perineal washing for prevention of recurrent urinary tract infections. Urology XXV: 492-494. (10.1016/0090-4295(85)90458-3)
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Dates

Type	When
Created	22 years, 9 months ago (Nov. 18, 2002, 6:04 p.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 9:33 p.m.)
Indexed	3 months, 2 weeks ago (May 15, 2025, 6:05 a.m.)
Issued	22 years, 8 months ago (Dec. 1, 2002)
Published	22 years, 8 months ago (Dec. 1, 2002)
Published Print	22 years, 8 months ago (Dec. 1, 2002)

Funders 0

None

BibTeX

@article{Schilling_2002, title={Effect of Trimethoprim-Sulfamethoxazole on Recurrent Bacteriuria and Bacterial Persistence in Mice Infected with Uropathogenic Escherichia coli}, volume={70}, ISSN={1098-5522}, url={http://dx.doi.org/10.1128/iai.70.12.7042-7049.2002}, DOI={10.1128/iai.70.12.7042-7049.2002}, number={12}, journal={Infection and Immunity}, publisher={American Society for Microbiology}, author={Schilling, Joel D. and Lorenz, Robin G. and Hultgren, Scott J.}, year={2002}, month=dec, pages={7042–7049} }

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