DOI: 10.1128/iai.69.12.7880-7888.2001. Epithelial Cells Infected with<i>Chlamydophila pneumoniae</i>(<i>Chlamydia pneumoniae</i>) Are Resistant to Apoptosis

Epithelial Cells Infected withChlamydophila pneumoniae(Chlamydia pneumoniae) Are Resistant to Apoptosis

10.1128/iai.69.12.7880-7888.2001

Crossref journal-article

American Society for Microbiology

Infection and Immunity (235)

Abstract

ABSTRACTThe obligate intracellular pathogenChlamydophila pneumoniae(Chlamydia pneumoniae) initiates infections in humans via the mucosal epithelia of the respiratory tract. Here, we report that epithelial cells infected withC. pneumoniaeare resistant to apoptosis induced by treatment with drugs or by death receptor ligation. The induction of protection from apoptosis depended on the infection conditions since only cells containing large inclusions were protected. The underlying mechanism of infection-induced apoptosis resistance probably involves mitochondria, the major integrators of apoptotic signaling. In the infected cells, mitochondria did not respond to apoptotic stimuli by the release of apoptogenic factors required for the activation of caspases. Consequently, active caspase-3 was absent in infected cells. Our data suggest a direct modulation of apoptotic pathways in epithelial cells byC. pneumoniae.

Bibliography

Rajalingam, K., Al-Younes, H., MuÌller, A., Meyer, T. F., Szczepek, A. J., & Rudel, T. (2001). Epithelial Cells Infected withChlamydophila pneumoniae(Chlamydia pneumoniae) Are Resistant to Apoptosis. Infection and Immunity, 69(12), 7880â7888.

Authors 6

Krishnaraj Rajalingam (first)
Hesham Al-Younes (additional)
Anne Müller (additional)
Thomas F. Meyer (additional)
Agnes J. Szczepek (additional)
Thomas Rudel (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 6:01 a.m.)
Deposited	2 years, 4 months ago (April 23, 2023, 11:28 a.m.)
Indexed	6 hours, 41 minutes ago (Sept. 3, 2025, 7:09 a.m.)
Issued	23 years, 9 months ago (Dec. 1, 2001)
Published	23 years, 9 months ago (Dec. 1, 2001)
Published Print	23 years, 9 months ago (Dec. 1, 2001)

Funders 0

None

BibTeX

@article{Rajalingam_2001, title={Epithelial Cells Infected withChlamydophila pneumoniae(Chlamydia pneumoniae) Are Resistant to Apoptosis}, volume={69}, ISSN={1098-5522}, url={http://dx.doi.org/10.1128/iai.69.12.7880-7888.2001}, DOI={10.1128/iai.69.12.7880-7888.2001}, number={12}, journal={Infection and Immunity}, publisher={American Society for Microbiology}, author={Rajalingam, Krishnaraj and Al-Younes, Hesham and Müller, Anne and Meyer, Thomas F. and Szczepek, Agnes J. and Rudel, Thomas}, editor={Tuomanen, E. I.}, year={2001}, month=dec, pages={7880–7888} }

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