DOI: 10.1128/iai.68.7.4323-4326.2000. Motility Is Required To Initiate Host Cell Invasion by <i>Yersinia enterocolitica</i>

Motility Is Required To Initiate Host Cell Invasion by Yersinia enterocolitica

10.1128/iai.68.7.4323-4326.2000

Crossref journal-article

American Society for Microbiology

Infection and Immunity (235)

Abstract

ABSTRACT Invasin-mediated invasion of host cells by the pathogen Yersinia enterocolitica was shown to be affected by flagellar-dependent motility. Motility appears to be required to ensure the bacterium migrates to and contacts the host cell. Nonmotile strains of Y. enterocolitica were less invasive than motile strains, but the reduction in invasion could be overcome by artificially bringing the bacteria into host cell contact by centrifugation. Mutations in known regulatory genes of the flagellar regulon, flhDC and fliA , resulted in less inv expression but did not have a significant effect on invasin levels. However, invasin levels were reduced for strains that harbored flhDC on a multicopy plasmid, apparently as a result of increased proteolysis of invasin.

Bibliography

Young, G. M., Badger, J. L., & Miller, V. L. (2000). Motility Is Required To Initiate Host Cell Invasion by Yersinia enterocolitica. Infection and Immunity, 68(7), 4323â4326.

Authors 3

Glenn M. Young (first)
Julie L. Badger (additional)
Virginia L. Miller (additional)

References 21 Referenced 84

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 6:01 a.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 8:44 p.m.)
Indexed	1 month, 1 week ago (July 20, 2025, 12:27 a.m.)
Issued	25 years, 1 month ago (July 1, 2000)
Published	25 years, 1 month ago (July 1, 2000)
Published Print	25 years, 1 month ago (July 1, 2000)

Funders 0

None

BibTeX

@article{Young_2000, title={Motility Is Required To Initiate Host Cell Invasion by Yersinia enterocolitica}, volume={68}, ISSN={1098-5522}, url={http://dx.doi.org/10.1128/iai.68.7.4323-4326.2000}, DOI={10.1128/iai.68.7.4323-4326.2000}, number={7}, journal={Infection and Immunity}, publisher={American Society for Microbiology}, author={Young, Glenn M. and Badger, Julie L. and Miller, Virginia L.}, editor={DiRita, V. J.}, year={2000}, month=jul, pages={4323–4326} }

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