DOI: 10.1128/iai.67.5.2615-2618.1999. The Siderophore 2,3-Dihydroxybenzoic Acid Is Not Required for Virulence of <i>Brucella abortus</i> in BALB/c Mice

The Siderophore 2,3-Dihydroxybenzoic Acid Is Not Required for Virulence of Brucella abortus in BALB/c Mice

10.1128/iai.67.5.2615-2618.1999

Crossref journal-article

American Society for Microbiology

Infection and Immunity (235)

Abstract

ABSTRACT 2,3-Dihydroxybenzoic acid (DHBA) is the only siderophore described for Brucella , and previous studies suggested that DHBA might contribute to the capacity of these organisms to persist in host macrophages. Employing an isogenic siderophore mutant ( ΔentC ) constructed from virulent Brucella abortus 2308, however, we found that production of DHBA is not required for replication in cultured murine macrophages or for the establishment and maintenance of chronic infection in the BALB/c mouse model.

Bibliography

Bellaire, B. H., Elzer, P. H., Baldwin, C. L., & Roop, R. M. (1999). The Siderophore 2,3-Dihydroxybenzoic Acid Is Not Required for Virulence of Brucella abortus in BALB/c Mice. Infection and Immunity, 67(5), 2615â2618.

Authors 4

Bryan H. Bellaire (first)
Philip H. Elzer (additional)
Cynthia L. Baldwin (additional)
R. Martin Roop (additional)

References 27 Referenced 41

10.1016/S0021-9258(18)74509-2
10.1128/jb.173.16.5121-5128.1991
Bellaire B. H. Baldwin C. L. Elzer P. H. Roop R. M. II. Contribution of the Brucella abortus 2 3-dihydroxybenzoic acid (DHBA) biosynthesis operon to virulence in ruminants abstr. 4 Proceedings of the 79th Annual Conference of Research Workers in Animal Disease 1998 43
10.1172/JCI114038
Earhart C. F. Uptake and metabolism of iron and molybdenum Escherichia coli and Salmonella: cellular and molecular biology 2nd ed. Neidhardt F. C. Curtiss R. III Ingraham J. L. Lin E. C. C. Low K. B. Magasanik B. Reznikoff W. S. Riley M. Schaechter M. Umbarger H. E. 1996 1075 1090 American Society for Microbiology Washington D.C
10.1128/iai.62.10.4135-4139.1994
10.1128/iai.64.11.4838-4841.1996
10.1021/bi970453p
10.1016/S0022-2836(83)80284-8
10.1128/iai.62.11.5120-5125.1994
10.1128/iai.61.1.124-134.1993
Leonard B. A. Benson R. López-Goñi I. Baldwin C. L. Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) protects brucellae from killing by macrophages.Vet. Res.2819978792 / Vet. Res. / Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) protects brucellae from killing by macrophages by Leonard B. A. (1997)
10.1128/iai.60.11.4496-4503.1992
10.1007/BF00314582
10.1073/pnas.82.23.8129
10.1007/BF00149553
10.1128/jb.171.2.784-790.1989
10.1128/jb.171.2.775-783.1989
10.1016/0966-842X(93)90036-Q
Sambrook J. Fritsch E. F. Maniatis T. Molecular cloning: a laboratory manual 2nd ed. 1989 Cold Spring Harbor Laboratory Press Cold Spring Harbor N.Y
10.1073/pnas.74.12.5463
10.1016/0003-2697(87)90612-9
Snedecor G. W. Cochran W. G. Statistical methods 8th ed. 1989 Iowa State University Press Ames
10.1111/j.1365-2958.1994.tb00350.x
10.3109/03602539008991450
10.1128/iai.26.3.925-932.1979
10.1111/j.1574-6976.1993.tb00026.x

Dates

Type	When
Created	5 years, 8 months ago (Dec. 31, 2019, 10:35 a.m.)
Deposited	3 years, 6 months ago (March 4, 2022, 7:56 p.m.)
Indexed	1 month, 4 weeks ago (July 8, 2025, 1:46 a.m.)
Issued	26 years, 4 months ago (May 1, 1999)
Published	26 years, 4 months ago (May 1, 1999)
Published Print	26 years, 4 months ago (May 1, 1999)

Funders 0

None

BibTeX

@article{Bellaire_1999, title={The Siderophore 2,3-Dihydroxybenzoic Acid Is Not Required for Virulence of Brucella abortus in BALB/c Mice}, volume={67}, ISSN={1098-5522}, url={http://dx.doi.org/10.1128/iai.67.5.2615-2618.1999}, DOI={10.1128/iai.67.5.2615-2618.1999}, number={5}, journal={Infection and Immunity}, publisher={American Society for Microbiology}, author={Bellaire, Bryan H. and Elzer, Philip H. and Baldwin, Cynthia L. and Roop, R. Martin}, editor={Moore, R. N.}, year={1999}, month=may, pages={2615–2618} }

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