DOI: 10.1128/iai.37.1.151-154.1982. Release of toxic microvesicles by Actinobacillus actinomycetemcomitans

Release of toxic microvesicles by Actinobacillus actinomycetemcomitans

10.1128/iai.37.1.151-154.1982

Crossref journal-article

American Society for Microbiology

Infection and Immunity (235)

Abstract

Oral isolates of Actinobacillus actinomycetemcomitans (strain Y4) release spherical microvesicles in large numbers during normal growth. The biological activities of these products were studied, and it was estimated that approximately 1/10 of their dry weight was made up of heat- and proteolysis-resistant endotoxin. The chicken embryo lethality and bone-resorbing activity of the microvesicles were heat stable but proteolysis sensitive. Other laboratories have reported the presence of a heat- and proteolysis-sensitive leukotoxin in similar preparations. Accordingly, the microvesicles released by strain Y4 may contain, in addition to endotoxin, several potent substances which are highly toxic and active in bone resorption, and these may be significant factors in the pathogenesis of periodontal diseases.

Bibliography

Nowotny, A., Behling, U. H., Hammond, B., Lai, C. H., Listgarten, M., Pham, P. H., & Sanavi, F. (1982). Release of toxic microvesicles by Actinobacillus actinomycetemcomitans. Infection and Immunity, 37(1), 151â154.

Authors 7

A Nowotny (first)
U H Behling (additional)
B Hammond (additional)
C H Lai (additional)
M Listgarten (additional)
P H Pham (additional)
F Sanavi (additional)

References 0 Referenced 94

None

Dates

Type	When
Created	5 years, 7 months ago (Jan. 1, 2020, 12:32 a.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 5 p.m.)
Indexed	1 year, 2 months ago (June 21, 2024, 5:39 p.m.)
Issued	43 years, 1 month ago (July 1, 1982)
Published	43 years, 1 month ago (July 1, 1982)
Published Print	43 years, 1 month ago (July 1, 1982)

Funders 0

None

BibTeX

@article{Nowotny_1982, title={Release of toxic microvesicles by Actinobacillus actinomycetemcomitans}, volume={37}, ISSN={1098-5522}, url={http://dx.doi.org/10.1128/iai.37.1.151-154.1982}, DOI={10.1128/iai.37.1.151-154.1982}, number={1}, journal={Infection and Immunity}, publisher={American Society for Microbiology}, author={Nowotny, A and Behling, U H and Hammond, B and Lai, C H and Listgarten, M and Pham, P H and Sanavi, F}, year={1982}, month=jul, pages={151–154} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        6,
        21
      ]
    ],
    "date-time": "2024-06-21T21:39:21Z",
    "timestamp": 1719005961679
  },
  "reference-count": 0,
  "publisher": "American Society for Microbiology",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1982,
            7,
            1
          ]
        ],
        "date-time": "1982-07-01T00:00:00Z",
        "timestamp": 394329600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://journals.asm.org/non-commercial-tdm-license"
    }
  ],
  "content-domain": {
    "domain": [
      "journals.asm.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1982,
        7
      ]
    ]
  },
  "abstract": "<jats:p>Oral isolates of Actinobacillus actinomycetemcomitans (strain Y4) release spherical microvesicles in large numbers during normal growth. The biological activities of these products were studied, and it was estimated that approximately 1/10 of their dry weight was made up of heat- and proteolysis-resistant endotoxin. The chicken embryo lethality and bone-resorbing activity of the microvesicles were heat stable but proteolysis sensitive. Other laboratories have reported the presence of a heat- and proteolysis-sensitive leukotoxin in similar preparations. Accordingly, the microvesicles released by strain Y4 may contain, in addition to endotoxin, several potent substances which are highly toxic and active in bone resorption, and these may be significant factors in the pathogenesis of periodontal diseases.</jats:p>",
  "DOI": "10.1128/iai.37.1.151-154.1982",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2020,
        1,
        1
      ]
    ],
    "date-time": "2020-01-01T05:32:31Z",
    "timestamp": 1577856751000
  },
  "page": "151-154",
  "update-policy": "http://dx.doi.org/10.1128/asmj-crossmark-policy-page",
  "source": "Crossref",
  "is-referenced-by-count": 94,
  "title": "Release of toxic microvesicles by Actinobacillus actinomycetemcomitans",
  "prefix": "10.1128",
  "volume": "37",
  "author": [
    {
      "given": "A",
      "family": "Nowotny",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "U H",
      "family": "Behling",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "B",
      "family": "Hammond",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "C H",
      "family": "Lai",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "M",
      "family": "Listgarten",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "P H",
      "family": "Pham",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "F",
      "family": "Sanavi",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "235",
  "container-title": "Infection and Immunity",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.asm.org/doi/pdf/10.1128/iai.37.1.151-154.1982",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://journals.asm.org/doi/pdf/10.1128/iai.37.1.151-154.1982",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        3,
        4
      ]
    ],
    "date-time": "2022-03-04T22:00:15Z",
    "timestamp": 1646431215000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://journals.asm.org/doi/10.1128/iai.37.1.151-154.1982"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1982,
        7
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1982,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1128/iai.37.1.151-154.1982"
  ],
  "URL": "http://dx.doi.org/10.1128/IAI.37.1.151-154.1982",
  "relation": {},
  "ISSN": [
    "0019-9567",
    "1098-5522"
  ],
  "subject": [],
  "container-title-short": "Infect Immun",
  "published": {
    "date-parts": [
      [
        1982,
        7
      ]
    ]
  },
  "assertion": [
    {
      "value": "1982-07-01",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}