DOI: 10.1128/iai.11.5.982-985.1975. Inhibition of the steroidogenic effects of cholera and heat-labile Escherichia coli enterotoxins by GM1 ganglioside: evidence for a similar receptor site for the two toxins

Inhibition of the steroidogenic effects of cholera and heat-labile Escherichia coli enterotoxins by GM1 ganglioside: evidence for a similar receptor site for the two toxins

10.1128/iai.11.5.982-985.1975

Crossref journal-article

American Society for Microbiology

Infection and Immunity (235)

Abstract

The effects of three different ganglioside preparations on cholera enterotoxin (CT) and heat-labile Escherichia coli enterotoxin (ECT)-induced steroidogenesis in Y1 and OS3 adrenal tumor cells in tissue culture were examined. Only with GM1 ganglioside was any inhibition of the toxins' effects noted. Concentrations of the crude ECT preparation that gave similar morphogenic and steroidogenic effects as CT were inhibited by the same amount or less of GM1 as that required to inhibit the effects of CT. The results of competition experiments also demonstrated that previous incubation of GM1 with one toxin could inhibit the ganglioside's ability to inactivate the other toxin. These findings indicate that at least for Y1 and OS3 adrenal tumor cells, GM1 may resemble or be the receptor for both CT and ECT.

Bibliography

Donta, S. T., & Viner, J. P. (1975). Inhibition of the steroidogenic effects of cholera and heat-labile Escherichia coli enterotoxins by GM1 ganglioside: evidence for a similar receptor site for the two toxins. Infection and Immunity, 11(5), 982â985.

Authors 2

S T Donta (first)
J P Viner (additional)

References 0 Referenced 54

None

Dates

Type	When
Created	5 years, 8 months ago (Jan. 1, 2020, 12:13 a.m.)
Deposited	3 years, 6 months ago (March 4, 2022, 3:37 p.m.)
Indexed	4 weeks, 1 day ago (Aug. 7, 2025, 5:09 a.m.)
Issued	50 years, 4 months ago (May 1, 1975)
Published	50 years, 4 months ago (May 1, 1975)
Published Print	50 years, 4 months ago (May 1, 1975)

Funders 0

None

BibTeX

@article{Donta_1975, title={Inhibition of the steroidogenic effects of cholera and heat-labile Escherichia coli enterotoxins by GM1 ganglioside: evidence for a similar receptor site for the two toxins}, volume={11}, ISSN={1098-5522}, url={http://dx.doi.org/10.1128/iai.11.5.982-985.1975}, DOI={10.1128/iai.11.5.982-985.1975}, number={5}, journal={Infection and Immunity}, publisher={American Society for Microbiology}, author={Donta, S T and Viner, J P}, year={1975}, month=may, pages={982–985} }

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