DOI: 10.1128/aem.71.1.562-565.2005. Maturation by LctT Is Required for Biosynthesis of Full-Length Lantibiotic Lacticin 481

Maturation by LctT Is Required for Biosynthesis of Full-Length Lantibiotic Lacticin 481

10.1128/aem.71.1.562-565.2005

Crossref journal-article

American Society for Microbiology

Applied and Environmental Microbiology (235)

Abstract

ABSTRACT In lantibiotic lacticin 481 biosynthesis, LctT cleaves the precursor peptide and exports mature lantibiotic. Matrix-assisted laser desorption ionization-time of flight mass spectrometry revealed that a truncated form of lacticin 481 is produced in the absence of LctT or after cleavage site inactivation. Production of truncated lacticin 481 is 4-fold less efficient, and its specific activity is about 10-fold lower.

Bibliography

Uguen, P., HindrÃ©, T., Didelot, S., Marty, C., Haras, D., Le Pennec, J.-P., VallÃ©e-RÃ©hel, K., & Dufour, A. (2005). Maturation by LctT Is Required for Biosynthesis of Full-Length Lantibiotic Lacticin 481. Applied and Environmental Microbiology, 71(1), 562â565.

Authors 8

Patricia Uguen (first)
Thomas Hindré (additional)
Sandrine Didelot (additional)
Christel Marty (additional)
Dominique Haras (additional)
Jean-Paul Le Pennec (additional)
Karine Vallée-Réhel (additional)
Alain Dufour (additional)

References 27 Referenced 33

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Dufour, A., A. Rincé, T. Hindré, D. Haras, and J.-P. Le Pennec. 2003. Lacticin 481: an antimicrobial peptide of the lantibiotic family produced by Lactococcus lactis. Recent Res. Dev. Bacteriol.1:219-234. / Recent Res. Dev. Bacteriol. (2003)
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Dates

Type	When
Created	20 years, 7 months ago (Jan. 7, 2005, 7:21 a.m.)
Deposited	3 years, 6 months ago (Feb. 22, 2022, 9:05 p.m.)
Indexed	3 months, 3 weeks ago (May 14, 2025, 8:09 p.m.)
Issued	20 years, 8 months ago (Jan. 1, 2005)
Published	20 years, 8 months ago (Jan. 1, 2005)
Published Print	20 years, 8 months ago (Jan. 1, 2005)

Funders 0

None

BibTeX

@article{Uguen_2005, title={Maturation by LctT Is Required for Biosynthesis of Full-Length Lantibiotic Lacticin 481}, volume={71}, ISSN={1098-5336}, url={http://dx.doi.org/10.1128/aem.71.1.562-565.2005}, DOI={10.1128/aem.71.1.562-565.2005}, number={1}, journal={Applied and Environmental Microbiology}, publisher={American Society for Microbiology}, author={Uguen, Patricia and Hindré, Thomas and Didelot, Sandrine and Marty, Christel and Haras, Dominique and Le Pennec, Jean-Paul and Vallée-Réhel, Karine and Dufour, Alain}, year={2005}, month=jan, pages={562–565} }

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