DOI: 10.1128/aem.01891-06. Species-Specific Secondary Metabolite Production in Marine Actinomycetes of the Genus <i>Salinispora</i>

Species-Specific Secondary Metabolite Production in Marine Actinomycetes of the Genus Salinispora

10.1128/aem.01891-06

Crossref journal-article

American Society for Microbiology

Applied and Environmental Microbiology (235)

Abstract

ABSTRACT Here we report associations between secondary metabolite production and phylogenetically distinct but closely related marine actinomycete species belonging to the genus Salinispora . The pattern emerged in a study that included global collection sites, and it indicates that secondary metabolite production can be a species-specific, phenotypic trait associated with broadly distributed bacterial populations. Associations between actinomycete phylotype and chemotype revealed an effective, diversity-based approach to natural product discovery that contradicts the conventional wisdom that secondary metabolite production is strain specific. The structural diversity of the metabolites observed, coupled with gene probing and phylogenetic analyses, implicates lateral gene transfer as a source of the biosynthetic genes responsible for compound production. These results conform to a model of selection-driven pathway fixation occurring subsequent to gene acquisition and provide a rare example in which demonstrable physiological traits have been correlated to the fine-scale phylogenetic architecture of an environmental bacterial community.

Bibliography

Jensen, P. R., Williams, P. G., Oh, D.-C., Zeigler, L., & Fenical, W. (2007). Species-Specific Secondary Metabolite Production in Marine Actinomycetes of the Genus Salinispora. Applied and Environmental Microbiology, 73(4), 1146â1152.

Authors 5

Paul R. Jensen (first)
Philip G. Williams (additional)
Dong-Chan Oh (additional)
Lisa Zeigler (additional)
William Fenical (additional)

References 40 Referenced 271

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Dates

Type	When
Created	18 years, 8 months ago (Dec. 8, 2006, 9:03 p.m.)
Deposited	3 years, 6 months ago (Feb. 22, 2022, 9:03 p.m.)
Indexed	4 weeks, 2 days ago (Aug. 6, 2025, 9:18 a.m.)
Issued	18 years, 6 months ago (Feb. 15, 2007)
Published	18 years, 6 months ago (Feb. 15, 2007)
Published Print	18 years, 6 months ago (Feb. 15, 2007)

Funders 0

None

BibTeX

@article{Jensen_2007, title={Species-Specific Secondary Metabolite Production in Marine Actinomycetes of the Genus Salinispora}, volume={73}, ISSN={1098-5336}, url={http://dx.doi.org/10.1128/aem.01891-06}, DOI={10.1128/aem.01891-06}, number={4}, journal={Applied and Environmental Microbiology}, publisher={American Society for Microbiology}, author={Jensen, Paul R. and Williams, Philip G. and Oh, Dong-Chan and Zeigler, Lisa and Fenical, William}, year={2007}, month=feb, pages={1146–1152} }

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