DOI: 10.1128/aac.9.2.239. Effect of Bleomycin on Deoxyribonucleic Acid Synthesis in Toluene-Treated <i>Escherichia coli</i> Cells

Effect of Bleomycin on Deoxyribonucleic Acid Synthesis in Toluene-Treated Escherichia coli Cells

10.1128/aac.9.2.239

Crossref journal-article

American Society for Microbiology

Antimicrobial Agents and Chemotherapy (235)

Abstract

The antibiotic bleomycin stimulates deoxyribonucleic acid (DNA) synthesis in toluene-treated Escherichia coli cells. The increase in synthesis is linear with bleomycin concentration. Bleomycin-stimulated DNA synthesis is independent of replication and dependent on DNA polymerase I. Replication is spared as the DNA polymerase I-dependent DNA synthesis increases. Bleomycin does not appear to have any effect on purified E. coli DNA polymerases I or II. Our results suggest that bleomycin causes nicking of the bacterial chromosome with subsequent DNA synthesis catalyzed by DNA polymerase I.

Bibliography

Ross, S. L., & Moses, R. E. (1976). Effect of Bleomycin on Deoxyribonucleic Acid Synthesis in Toluene-Treated Escherichia coli Cells. Antimicrobial Agents and Chemotherapy, 9(2), 239â246.

Authors 2

Steven L. Ross (first)
Robb E. Moses (additional)

References 0 Referenced 15

None

Dates

Type	When
Created	13 years, 2 months ago (June 27, 2012, 7:57 p.m.)
Deposited	3 years, 6 months ago (Feb. 21, 2022, 8:22 a.m.)
Indexed	2 years, 5 months ago (March 16, 2023, 6:31 p.m.)
Issued	49 years, 7 months ago (Feb. 1, 1976)
Published	49 years, 7 months ago (Feb. 1, 1976)
Published Print	49 years, 7 months ago (Feb. 1, 1976)

Funders 0

None

BibTeX

@article{Ross_1976, title={Effect of Bleomycin on Deoxyribonucleic Acid Synthesis in Toluene-Treated Escherichia coli Cells}, volume={9}, ISSN={1098-6596}, url={http://dx.doi.org/10.1128/aac.9.2.239}, DOI={10.1128/aac.9.2.239}, number={2}, journal={Antimicrobial Agents and Chemotherapy}, publisher={American Society for Microbiology}, author={Ross, Steven L. and Moses, Robb E.}, year={1976}, month=feb, pages={239–246} }

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