Anti-Kaposi’s Sarcoma and Antiangiogenic Activities of Sulfated Dextrins
10.1128/aac.43.10.2528
Crossref journal-article
American Society for Microbiology
Antimicrobial Agents and Chemotherapy (235)
Abstract

ABSTRACTDelivery of the sulfated polysaccharide dextrin 2-sulfate by the intraperitoneal route to the lymphatic circulation resulted in a clinically significant improvement in Kaposi’s sarcoma in three patients. Our in vitro studies show that although sulfated dextrins do not interfere with the growth of isolated human umbilical vein endothelial cells, they do inhibit the morphological differentiation of endothelial cells into tubes as well as reduce new vessel formation in a placental angiogenesis assay. The antiangiogenic effect of dextrin 6-sulfate is greater than that of dextrin 2-sulfate and is independent of their anti-human immunodeficiency virus type 1 activities.

Bibliography

Thornton, M., Barkley, L., Mason, J. C., & Shaunak, S. (1999). Anti-Kaposi’s Sarcoma and Antiangiogenic Activities of Sulfated Dextrins. Antimicrobial Agents and Chemotherapy, 43(10), 2528–2533.

Authors 4
  1. Mark Thornton (first)
  2. Laura Barkley (additional)
  3. Justin C. Mason (additional)
  4. Sunil Shaunak (additional)
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Dates
Type When
Created 6 years, 10 months ago (Oct. 8, 2018, 8:33 p.m.)
Deposited 1 year, 11 months ago (Sept. 5, 2023, 3:47 p.m.)
Indexed 1 year, 6 months ago (Feb. 20, 2024, 12:04 p.m.)
Issued 25 years, 10 months ago (Oct. 1, 1999)
Published 25 years, 10 months ago (Oct. 1, 1999)
Published Print 25 years, 10 months ago (Oct. 1, 1999)
Funders 0

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@article{Thornton_1999, title={Anti-Kaposi’s Sarcoma and Antiangiogenic Activities of Sulfated Dextrins}, volume={43}, ISSN={1098-6596}, url={http://dx.doi.org/10.1128/aac.43.10.2528}, DOI={10.1128/aac.43.10.2528}, number={10}, journal={Antimicrobial Agents and Chemotherapy}, publisher={American Society for Microbiology}, author={Thornton, Mark and Barkley, Laura and Mason, Justin C. and Shaunak, Sunil}, year={1999}, month=oct, pages={2528–2533} }