DOI: 10.1128/aac.41.5.1196. In vitro activity of RU 64004, a new ketolide antibiotic, against gram-positive bacteria

In vitro activity of RU 64004, a new ketolide antibiotic, against gram-positive bacteria

10.1128/aac.41.5.1196

Crossref journal-article

American Society for Microbiology

Antimicrobial Agents and Chemotherapy (235)

Abstract

The comparative in vitro activity of RU 64004 (also known as HMR 3004), a new ketolide antibiotic, was tested by agar dilution against approximately 500 gram-positive organisms, including multiply resistant enterococci, streptococci, and staphylococci. All streptococci were inhibited by < or = 1 microg of RU 64004 per ml. The ketolide was more potent than other macrolides against erythromycin A-susceptible staphylococci and was generally more potent than clindamycin against erythromycin A-resistant strains susceptible to this agent. Clindamycin-resistant staphylococci (MIC, > 128 microg/ml) proved resistant to the ketolide, but some erythromycin A- and clindamycin-resistant enterococci remained susceptible to RU 64004.

Bibliography

SchÃ¼lin, T., Wennersten, C. B., Moellering, R. C., & Eliopoulos, G. M. (1997). In vitro activity of RU 64004, a new ketolide antibiotic, against gram-positive bacteria. Antimicrobial Agents and Chemotherapy, 41(5), 1196â1202.

Authors 4

T Schülin (first)
C B Wennersten (additional)
R C Moellering (additional)
G M Eliopoulos (additional)

References 0 Referenced 33

None

Dates

Type	When
Created	6 years, 10 months ago (Oct. 8, 2018, 8:28 p.m.)
Deposited	3 years, 6 months ago (Feb. 21, 2022, 3:13 p.m.)
Indexed	1 year, 10 months ago (Oct. 14, 2023, 5:31 a.m.)
Issued	28 years, 3 months ago (May 1, 1997)
Published	28 years, 3 months ago (May 1, 1997)
Published Print	28 years, 3 months ago (May 1, 1997)

Funders 0

None

BibTeX

@article{Sch_lin_1997, title={In vitro activity of RU 64004, a new ketolide antibiotic, against gram-positive bacteria}, volume={41}, ISSN={1098-6596}, url={http://dx.doi.org/10.1128/aac.41.5.1196}, DOI={10.1128/aac.41.5.1196}, number={5}, journal={Antimicrobial Agents and Chemotherapy}, publisher={American Society for Microbiology}, author={Schülin, T and Wennersten, C B and Moellering, R C and Eliopoulos, G M}, year={1997}, month=may, pages={1196–1202} }

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