DOI: 10.1128/aac.40.6.1335. Rifapentine is active in vitro and in vivo against Toxoplasma gondii

Rifapentine is active in vitro and in vivo against Toxoplasma gondii

10.1128/aac.40.6.1335

Crossref journal-article

American Society for Microbiology

Antimicrobial Agents and Chemotherapy (235)

Abstract

Rifapentine, a derivative of rifamycin, was examined for its in vitro and in vivo activities against the protozoan parasite Toxoplasma gondii. The drug inhibited the intracellular replication of parasites and was not cytotoxic for the host cells at inhibitory concentrations. Mice infected either intraperitoneally with tachyzoites of the RH strain or orally with tissue cysts of the C56 strain were protected against death by treatment with rifapentine. The degree of protection was similar to that induced by atovaquone and apparently higher than that induced by rifabutin. Rifapentine may be a useful drug for the treatment of toxoplasmosis in immunocompromised individuals.

Bibliography

Araujo, F. G., Khan, A. A., & Remington, J. S. (1996). Rifapentine is active in vitro and in vivo against Toxoplasma gondii. Antimicrobial Agents and Chemotherapy, 40(6), 1335â1337.

Authors 3

F G Araujo (first)
A A Khan (additional)
J S Remington (additional)

References 0 Referenced 25

None

Dates

Type	When
Created	6 years, 10 months ago (Oct. 8, 2018, 8:25 p.m.)
Deposited	3 years, 6 months ago (Feb. 21, 2022, 3:07 p.m.)
Indexed	1 year ago (Aug. 7, 2024, 6:34 p.m.)
Issued	29 years, 2 months ago (June 1, 1996)
Published	29 years, 2 months ago (June 1, 1996)
Published Print	29 years, 2 months ago (June 1, 1996)

Funders 0

None

BibTeX

@article{Araujo_1996, title={Rifapentine is active in vitro and in vivo against Toxoplasma gondii}, volume={40}, ISSN={1098-6596}, url={http://dx.doi.org/10.1128/aac.40.6.1335}, DOI={10.1128/aac.40.6.1335}, number={6}, journal={Antimicrobial Agents and Chemotherapy}, publisher={American Society for Microbiology}, author={Araujo, F G and Khan, A A and Remington, J S}, year={1996}, month=jun, pages={1335–1337} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        8,
        7
      ]
    ],
    "date-time": "2024-08-07T22:34:40Z",
    "timestamp": 1723070080150
  },
  "reference-count": 0,
  "publisher": "American Society for Microbiology",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1996,
            6,
            1
          ]
        ],
        "date-time": "1996-06-01T00:00:00Z",
        "timestamp": 833587200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://journals.asm.org/non-commercial-tdm-license"
    }
  ],
  "content-domain": {
    "domain": [
      "journals.asm.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1996,
        6
      ]
    ]
  },
  "abstract": "<jats:p>Rifapentine, a derivative of rifamycin, was examined for its in vitro and in vivo activities against the protozoan parasite Toxoplasma gondii. The drug inhibited the intracellular replication of parasites and was not cytotoxic for the host cells at inhibitory concentrations. Mice infected either intraperitoneally with tachyzoites of the RH strain or orally with tissue cysts of the C56 strain were protected against death by treatment with rifapentine. The degree of protection was similar to that induced by atovaquone and apparently higher than that induced by rifabutin. Rifapentine may be a useful drug for the treatment of toxoplasmosis in immunocompromised individuals.</jats:p>",
  "DOI": "10.1128/aac.40.6.1335",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2018,
        10,
        9
      ]
    ],
    "date-time": "2018-10-09T00:25:38Z",
    "timestamp": 1539044738000
  },
  "page": "1335-1337",
  "update-policy": "http://dx.doi.org/10.1128/asmj-crossmark-policy-page",
  "source": "Crossref",
  "is-referenced-by-count": 25,
  "title": "Rifapentine is active in vitro and in vivo against Toxoplasma gondii",
  "prefix": "10.1128",
  "volume": "40",
  "author": [
    {
      "given": "F G",
      "family": "Araujo",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, California 94301, USA. ml.fga@forsythe.stanford.edu"
        }
      ]
    },
    {
      "given": "A A",
      "family": "Khan",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, California 94301, USA. ml.fga@forsythe.stanford.edu"
        }
      ]
    },
    {
      "given": "J S",
      "family": "Remington",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, California 94301, USA. ml.fga@forsythe.stanford.edu"
        }
      ]
    }
  ],
  "member": "235",
  "container-title": "Antimicrobial Agents and Chemotherapy",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.asm.org/doi/pdf/10.1128/AAC.40.6.1335",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://journals.asm.org/doi/pdf/10.1128/AAC.40.6.1335",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        2,
        21
      ]
    ],
    "date-time": "2022-02-21T20:07:59Z",
    "timestamp": 1645474079000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://journals.asm.org/doi/10.1128/AAC.40.6.1335"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1996,
        6
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          1996,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1128/AAC.40.6.1335"
  ],
  "URL": "http://dx.doi.org/10.1128/AAC.40.6.1335",
  "relation": {},
  "ISSN": [
    "0066-4804",
    "1098-6596"
  ],
  "subject": [],
  "container-title-short": "Antimicrob Agents Chemother",
  "published": {
    "date-parts": [
      [
        1996,
        6
      ]
    ]
  },
  "assertion": [
    {
      "value": "1996-06-01",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}