Abstract
Aphidicolin is an antibiotic of novel structure produced by the mold Cephalosporium aphidicola . It is a potent inhibitor of cellular deoxyribonucleic acid synthesis, and it also strongly inhibits the growth of herpes simplex virus both in tissue culture and in the rabbit eye. Aphidicolin is active against iododeoxyuridine-resistant herpes virus, and does not itself readily induce the formation of drug-resistant strains of herpesvirus.
Dates
Type | When |
---|---|
Created | 13 years, 2 months ago (June 27, 2012, 7:57 p.m.) |
Deposited | 3 years, 6 months ago (Feb. 21, 2022, 6:10 p.m.) |
Indexed | 1 month, 2 weeks ago (July 9, 2025, 7:02 p.m.) |
Issued | 51 years, 11 months ago (Sept. 1, 1973) |
Published | 51 years, 11 months ago (Sept. 1, 1973) |
Published Print | 51 years, 11 months ago (Sept. 1, 1973) |
@article{Bucknall_1973, title={Antiviral Effects of Aphidicolin, a New Antibiotic Produced by Cephalosporium aphidicola}, volume={4}, ISSN={1098-6596}, url={http://dx.doi.org/10.1128/aac.4.3.294}, DOI={10.1128/aac.4.3.294}, number={3}, journal={Antimicrobial Agents and Chemotherapy}, publisher={American Society for Microbiology}, author={Bucknall, R. A. and Moores, H. and Simms, R. and Hesp, B.}, year={1973}, month=sep, pages={294–298} }