DOI: 10.1128/aac.26.4.591. Suppression of respiratory syncytial virus infection in cotton rats by bis(5-amidino-2-benzimidazolyl)methane

Suppression of respiratory syncytial virus infection in cotton rats by bis(5-amidino-2-benzimidazolyl)methane

10.1128/aac.26.4.591

Crossref journal-article

American Society for Microbiology

Antimicrobial Agents and Chemotherapy (235)

Abstract

Intraperitoneal administration of bis(5-amidino-2-benzimidazolyl)methane at well-tolerated daily doses of 25 mg/kg subsequent to challenge and for 3 days thereafter effected over a 1-log reduction in the amount of virus recovered from lungs of cotton rats inoculated intratracheally with respiratory syncytial virus. When animals were immunosuppressed to prolong virus shedding, the reduction in recovered virus achieved with a 7-day dosing schedule of bis(5-amidino-2-benzimidazolyl)methane exceeded 2 logs.

Bibliography

Tidwell, R. R., Geratz, J. D., Clyde, W. A., Rosenthal, K. U., & Dubovi, E. J. (1984). Suppression of respiratory syncytial virus infection in cotton rats by bis(5-amidino-2-benzimidazolyl)methane. Antimicrobial Agents and Chemotherapy, 26(4), 591â593.

Authors 5

R R Tidwell (first)
J D Geratz (additional)
W A Clyde (additional)
K U Rosenthal (additional)
E J Dubovi (additional)

References 0 Referenced 17

None

Dates

Type	When
Created	13 years, 2 months ago (June 27, 2012, 8:03 p.m.)
Deposited	3 years, 6 months ago (Feb. 21, 2022, 9:42 a.m.)
Indexed	1 year, 9 months ago (Nov. 23, 2023, 12:23 p.m.)
Issued	40 years, 10 months ago (Oct. 1, 1984)
Published	40 years, 10 months ago (Oct. 1, 1984)
Published Print	40 years, 10 months ago (Oct. 1, 1984)

Funders 0

None

BibTeX

@article{Tidwell_1984, title={Suppression of respiratory syncytial virus infection in cotton rats by bis(5-amidino-2-benzimidazolyl)methane}, volume={26}, ISSN={1098-6596}, url={http://dx.doi.org/10.1128/aac.26.4.591}, DOI={10.1128/aac.26.4.591}, number={4}, journal={Antimicrobial Agents and Chemotherapy}, publisher={American Society for Microbiology}, author={Tidwell, R R and Geratz, J D and Clyde, W A and Rosenthal, K U and Dubovi, E J}, year={1984}, month=oct, pages={591–593} }

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