DOI: 10.1128/aac.21.1.85. Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria

Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria

10.1128/aac.21.1.85

Crossref journal-article

American Society for Microbiology

Antimicrobial Agents and Chemotherapy (235)

Abstract

Azthreonam (SQ 26,776) is a synthetic monocyclic beta-lactam antimicrobial agent belonging to the monobactam family (Sykes et al., Nature [London] 291:489-491, 1981), members of which are characterized by having the 2-oxoazetidine-1-sulfonic acid moiety. Azthreonam exhibits a high degree of stability to beta-lactamases and is specifically active against aerobic gram-negative bacteria, including Pseudomonas aeruginosa. Its activity against these organisms was in general equal or superior to that observed with the third-generation cephalosporins, cefotaxime and ceftazidime. Like penicillins and cephalosporins, azthreonam interacts with essential penicillin-binding proteins of gram-negative bacteria. Azthreonam protected mice against experimental infections produced by a range of gram-negative bacteria, exhibiting efficacy comparable to that of cefotaxime and ceftazidime.

Bibliography

Sykes, R. B., Bonner, D. P., Bush, K., & Georgopapadakou, N. H. (1982). Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria. Antimicrobial Agents and Chemotherapy, 21(1), 85â92.

Authors 4

R B Sykes (first)
D P Bonner (additional)
K Bush (additional)
N H Georgopapadakou (additional)

References 0 Referenced 231

None

Dates

Type	When
Created	13 years, 2 months ago (June 27, 2012, 8:03 p.m.)
Deposited	3 years, 6 months ago (Feb. 21, 2022, 9:15 a.m.)
Indexed	1 day, 4 hours ago (Sept. 4, 2025, 10:10 a.m.)
Issued	43 years, 8 months ago (Jan. 1, 1982)
Published	43 years, 8 months ago (Jan. 1, 1982)
Published Print	43 years, 8 months ago (Jan. 1, 1982)

Funders 0

None

BibTeX

@article{Sykes_1982, title={Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria}, volume={21}, ISSN={1098-6596}, url={http://dx.doi.org/10.1128/aac.21.1.85}, DOI={10.1128/aac.21.1.85}, number={1}, journal={Antimicrobial Agents and Chemotherapy}, publisher={American Society for Microbiology}, author={Sykes, R B and Bonner, D P and Bush, K and Georgopapadakou, N H}, year={1982}, month=jan, pages={85–92} }

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