DOI: 10.1128/aac.15.3.368. Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties

Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties

10.1128/aac.15.3.368

Crossref journal-article

American Society for Microbiology

Antimicrobial Agents and Chemotherapy (235)

Abstract

The avermectins, a family of new anthelmintic agents, were isolated from the mycelia of Streptomyces avermitilis . Four closely related major components and four homologous minor components were separated from the complex. Solvent extraction, solvent partition, and adsorption methods were used to isolate and purify the complex; novel partition chromatography systems using Sephadex LH-20 were used to separate the components. A reverse-phase high-pressure liquid chromatography assay for the quantitative determination of all components was used extensively to monitor the purification methods.

Bibliography

Miller, T. W., Chaiet, L., Cole, D. J., Cole, L. J., Flor, J. E., Goegelman, R. T., Gullo, V. P., Joshua, H., Kempf, A. J., Krellwitz, W. R., Monaghan, R. L., Ormond, R. E., Wilson, K. E., Albers-SchÃ¶nberg, G., & Putter, I. (1979). Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties. Antimicrobial Agents and Chemotherapy, 15(3), 368â371.

Authors 15

Thomas W. Miller (first)
Louis Chaiet (additional)
Douglas J. Cole (additional)
Lucille J. Cole (additional)
James E. Flor (additional)
Robert T. Goegelman (additional)
Vincent P. Gullo (additional)
Henry Joshua (additional)
August J. Kempf (additional)
Wilson R. Krellwitz (additional)
Richard L. Monaghan (additional)
Robert E. Ormond (additional)
Kenneth E. Wilson (additional)
George Albers-Schönberg (additional)
Irving Putter (additional)

References 0 Referenced 147

None

Dates

Type	When
Created	13 years, 2 months ago (June 27, 2012, 7:57 p.m.)
Deposited	3 years, 6 months ago (Feb. 21, 2022, 9:04 a.m.)
Indexed	20 hours, 17 minutes ago (Sept. 3, 2025, 6:11 a.m.)
Issued	46 years, 6 months ago (March 1, 1979)
Published	46 years, 6 months ago (March 1, 1979)
Published Print	46 years, 6 months ago (March 1, 1979)

Funders 0

None

BibTeX

@article{Miller_1979, title={Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties}, volume={15}, ISSN={1098-6596}, url={http://dx.doi.org/10.1128/aac.15.3.368}, DOI={10.1128/aac.15.3.368}, number={3}, journal={Antimicrobial Agents and Chemotherapy}, publisher={American Society for Microbiology}, author={Miller, Thomas W. and Chaiet, Louis and Cole, Douglas J. and Cole, Lucille J. and Flor, James E. and Goegelman, Robert T. and Gullo, Vincent P. and Joshua, Henry and Kempf, August J. and Krellwitz, Wilson R. and Monaghan, Richard L. and Ormond, Robert E. and Wilson, Kenneth E. and Albers-Schönberg, George and Putter, Irving}, year={1979}, month=mar, pages={368–371} }

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