DOI: 10.1128/aac.01415-08. Regulation of <i>mprF</i> in Daptomycin-Nonsusceptible <i>Staphylococcus aureus</i> Strains

Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains

10.1128/aac.01415-08

Crossref journal-article

American Society for Microbiology

Antimicrobial Agents and Chemotherapy (235)

Abstract

ABSTRACT We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF -mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis.

Bibliography

Yang, S.-J., Xiong, Y. Q., Dunman, P. M., Schrenzel, J., FrancÌ§ois, P., Peschel, A., & Bayer, A. S. (2009). Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains. Antimicrobial Agents and Chemotherapy, 53(6), 2636â2637.

Authors 7

Soo-Jin Yang (first)
Yan Q. Xiong (additional)
Paul M. Dunman (additional)
Jacques Schrenzel (additional)
Patrice François (additional)
Andreas Peschel (additional)
Arnold S. Bayer (additional)

References 17 Referenced 96

Dates

Type	When
Created	16 years, 5 months ago (March 16, 2009, 8:54 p.m.)
Deposited	3 years, 6 months ago (Feb. 21, 2022, 6:18 p.m.)
Indexed	1 month, 2 weeks ago (July 20, 2025, 12:24 a.m.)
Issued	16 years, 3 months ago (June 1, 2009)
Published	16 years, 3 months ago (June 1, 2009)
Published Print	16 years, 3 months ago (June 1, 2009)

Funders 0

None

BibTeX

@article{Yang_2009, title={Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains}, volume={53}, ISSN={1098-6596}, url={http://dx.doi.org/10.1128/aac.01415-08}, DOI={10.1128/aac.01415-08}, number={6}, journal={Antimicrobial Agents and Chemotherapy}, publisher={American Society for Microbiology}, author={Yang, Soo-Jin and Xiong, Yan Q. and Dunman, Paul M. and Schrenzel, Jacques and François, Patrice and Peschel, Andreas and Bayer, Arnold S.}, year={2009}, month=jun, pages={2636–2637} }

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