DOI: 10.1126/stke.2002.134.re7. Paradigms of Growth Control: Relation to Cdk Activation

Paradigms of Growth Control: Relation to Cdk Activation

10.1126/stke.2002.134.re7

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science's STKE (221)

Abstract

The cyclin-dependent kinases (CDKs) play a key role in cell cycle control, and in this review, we focus on the events that regulate their activities. Emphasis is placed on the CDKs that function during the G 1 phase of the cell cycle and on the CDK inhibitor p27 Kip1 . We discuss how CDK activation relates to two basic concepts of cell cycle regulation: (i) the need for multiple mitogens for the proliferation of nontransformed cells and (ii) the inhibitory effect of high culture density on proliferative capacity. We also describe how Cdk2 modulates the expression of the α subunit of the interleukin-2 receptor in T cells, and address the question of whether p27 Kip1 functions as an activator or inhibitor of the CDKs associated with the D cyclins.

Bibliography

Olashaw, N., & Pledger, W. J. (2002). Paradigms of Growth Control: Relation to Cdk Activation. Scienceâs STKE, 2002(134).

Authors 2

Nancy Olashaw (first)
W. J. Pledger (additional)

References 194 Referenced 27

10.1146/annurev.bi.47.070178.003435
10.1016/0012-1606(65)90005-9
10.1016/0304-4165(69)90415-2
10.1016/0014-4827(74)90484-4
10.1002/jss.400130405
10.1146/annurev.bi.43.070174.001125
10.1073/pnas.71.4.1286
10.1073/pnas.75.6.2839
10.1073/pnas.74.10.4481
10.1016/0014-4827(82)90073-8
10.1073/pnas.76.3.1279
10.1073/pnas.81.8.2389
10.1126/science.3523754
10.1111/j.1600-065X.1982.tb00423.x
10.1073/pnas.82.12.4055
10.1016/0092-8674(86)90390-9
10.1016/S0955-0674(00)00151-4
10.1101/gad.9.10.1149
M. Ruas, G. Peters, The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim. Biophys. Acta 1378, F115-177 (1998). / Biochim. Biophys. Acta (1998)
E. J. Firpo, A. Koff, M. J. Solomon, J. M. Roberts, Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes. Mol. Cell. Biol. 14, 4889-4901 (1994). / Mol. Cell. Biol. (1994)
10.1038/372570a0
10.1091/mbc.6.9.1197
10.1074/jbc.271.19.11253
10.1074/jbc.271.31.18337
10.1128/MCB.16.8.4327
10.1074/jbc.272.11.7093
10.1091/mbc.9.8.2081
10.1073/pnas.95.3.1091
10.1126/science.272.5263.877
10.1016/S0092-8674(00)81237-4
10.1016/S0092-8674(00)81238-6
10.1016/S0092-8674(00)81239-8
10.1016/0092-8674(94)90572-X
10.1016/0092-8674(94)90573-8
10.1016/0092-8674(94)90257-7
10.1091/mbc.11.6.2117
10.1074/jbc.M010189200
P. Michieli, M. Chedid, D. Lin, J. H. Pierce, W. E. Mercer, D. Givol, Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res. 54, 3391-3395 (1994). / Cancer Res. (1994)
10.1083/jcb.131.1.235
L. Kivinen, M. Laiho, Ras- and mitogen-activated protein kinase kinase-dependent and -independent pathways in p21Cip1/Waf1 induction by fibroblast growth factor-2, platelet-derived growth factor, and transforming growth factor-β1. Cell Growth Differ. 10, 621-628 (1999). / Cell Growth Differ. (1999)
M. Gorospe, X. Wang, N. J. Holbrook, Functional role of p21 during the cellular response to stress. Gene Expr. 7, 377-385 (1999). / Gene Expr. (1999)
10.1038/377552a0
10.1016/0092-8674(95)90039-X
10.1667/0033-7587(2001)155[0554:PGAIIH]2.0.CO;2
10.1101/gad.9.6.639
10.1101/gad.9.6.650
10.1101/gad.9.15.1831
10.1073/pnas.93.24.13742
10.1146/annurev.pharmtox.39.1.295
10.1126/science.7624798
10.1126/science.271.5257.1861
10.1128/MCB.19.2.1190
10.1101/gad.11.11.1464
10.1093/emboj/16.17.5334
10.1006/bbrc.1997.7590
10.1101/gad.13.9.1181
10.1038/12013
10.1016/S0960-9822(99)80290-5
10.1038/18230
10.1074/jbc.M010811200
10.1126/science.1329201
10.1126/science.1388288
10.1016/0092-8674(95)90271-6
10.1093/emboj/17.2.368
10.1016/S0014-5793(99)00629-8
10.1038/8984
10.1038/sj.onc.1201228
10.1152/ajpcell.1999.277.4.C652
10.1074/jbc.M001144200
10.1074/jbc.M101714200
10.1128/MCB.17.9.5348
10.1128/MCB.20.16.5947-5959.2000
10.1128/MCB.21.15.4960-4967.2001
10.1074/jbc.274.45.32309
10.1101/gad.13.13.1742
10.1038/sj.onc.1204245
10.1128/MCB.20.24.9138-9148.2000
10.1083/jcb.148.3.543
10.1038/35008115
J. T. Winston, S. R. Coats, Y. Z. Wang, W. J. Pledger, Regulation of the cell cycle machinery by oncogenic ras. Oncogene 12, 127-134 (1996). / Oncogene (1996)
10.1074/jbc.272.52.32966
10.1038/sj.onc.1201105
10.1128/MCB.17.7.3850
10.1098/rstb.1996.0020
10.1016/S1074-7613(00)80388-X
10.1006/bbrc.1997.7885
10.1073/pnas.95.26.15406
10.1074/jbc.M007291200
10.1016/S0960-9822(01)00065-3
10.1074/jbc.272.22.14426
10.1073/pnas.96.11.6199
10.1128/MCB.20.23.8969-8982.2000
10.1074/jbc.M003145200
10.1016/S0092-8674(00)80595-4
10.1128/MCB.21.10.3534-3546.2001
10.1016/S0014-5793(01)02113-5
10.1038/35055073
10.1016/S0021-9258(18)53587-0
H. Matsushime, D. E. Quelle, S. A. Shurtleff, M. Shibuya, C. J. Sherr, J. Y. Kato, D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14, 2066-2076 (1994). / Mol. Cell. Biol. (1994)
M. Meyerson, E. Harlow, Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol. 14, 2077-2086 (1994). / Mol. Cell. Biol. (1994)
10.1038/sj.onc.1202575
10.1016/0092-8674(91)90101-4
10.1073/pnas.89.20.9910
10.1091/mbc.4.11.1133
10.1101/gad.7.5.812
10.1074/jbc.271.19.11484
J. Filmus, A. I. Robles, W. Shi, M. J. Wong, L. L. Colombo, C. J. Conti, Induction of cyclin D1 overexpression by activated ras. Oncogene 9, 3627-3633 (1994). / Oncogene (1994)
10.1128/MCB.15.7.3654
10.1101/gad.12.16.2469
10.1038/386177a0
10.1016/S0303-7207(01)00439-7
10.1074/jbc.270.40.23589
10.1074/jbc.271.34.20608
10.1101/gad.12.22.3499
10.1074/jbc.273.45.29864
10.1074/jbc.274.31.22033
10.1128/MCB.19.2.1346
10.1074/jbc.273.11.6190
10.1101/gad.10.12.1491
10.1101/gad.13.22.3027
10.1101/gad.11.8.957
10.1101/gad.854900
10.1038/378785a0
10.1074/jbc.273.21.13150
10.1074/jbc.275.16.12074
10.1101/gad.8.1.9
T. J. Soos, H. Kiyokawa, J. S. Yan, M. S. Rubin, A. Giordano, A. DeBlasio, S. Bottega, B. Wong, J. Mendelsohn, A. Koff, Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ. 7, 135-146 (1996). / Cell Growth Differ. (1996)
10.1074/jbc.272.41.25863
10.1093/emboj/18.6.1571
10.1101/gad.8.15.1750
10.1101/gad.11.7.847
10.1101/gad.13.12.1501
10.1128/MCB.19.3.1775
10.1128/MCB.20.23.8748-8757.2000
10.1101/gad.813200
10.1016/0092-8674(95)90385-2
10.1002/(SICI)1097-4652(199711)173:2<233::AID-JCP27>3.0.CO;2-F
10.1038/sj.onc.1204338
10.1038/35404
10.1016/S0092-8674(00)80940-X
10.1038/35410
10.1002/(SICI)1097-4652(200007)184:1<1::AID-JCP1>3.0.CO;2-7
10.1016/0092-8674(94)90405-7
10.1128/MCB.16.4.1576
10.1038/sj.onc.1204331
10.1128/MCB.18.2.753
10.1128/MCB.21.14.4773-4784.2001
10.1128/MCB.15.8.4215
10.1016/S0378-1119(00)00092-5
10.1016/S0092-8674(00)80625-X
10.1016/S0092-8674(00)81519-6
J. R. Nevins, Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth Differ. 9, 585-593 (1998). / Cell Growth Differ. (1998)
X. Mayol, J. Garriga, X. Grana, Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130. Oncogene 11, 801-808 (1995). / Oncogene (1995)
10.1101/gad.9.11.1340
10.1073/pnas.93.10.4633
10.1093/emboj/20.3.422
10.1074/jbc.M005707200
10.1101/gad.8.22.2680
10.1101/gad.8.22.2665
10.1101/gad.9.7.869
10.1128/MCB.15.6.3082
10.1073/pnas.92.6.2403
10.1101/gad.11.11.1447
10.1128/MCB.18.9.5380
10.1016/S0960-9822(99)80086-4
10.1074/jbc.272.36.22954
10.1016/S1097-2765(00)00072-1
M. Kiess, R. M. Gill, P. A. Hamel, Expression and activity of the retinoblastoma protein (pRB)-family proteins, p107 and p130, during L6 myoblast differentiation. Cell Growth Differ. 6, 1287-1298 (1995). / Cell Growth Differ. (1995)
X. Mayol, J. Garriga, X. Grana, G1 cyclin/CDK-independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with E2F-4. Oncogene 13, 237-246 (1996). / Oncogene (1996)
10.1016/S0960-9822(02)00515-8
10.1093/emboj/16.17.5322
10.1074/jbc.275.9.6337
10.1101/gad.10.7.851
10.1093/emboj/17.20.5987
10.1101/gad.8.15.1772
M. Xu, K. A. Sheppard, C. Y. Peng, A. S. Yee, H. Piwnica-Worms, Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol. Cell. Biol. 14, 8420-8431 (1994). / Mol. Cell. Biol. (1994)
10.1016/0092-8674(94)90582-7
10.1016/0092-8674(95)90141-8
10.1101/gad.10.16.1979
10.1002/j.1460-2075.1996.tb00793.x
10.1074/jbc.275.5.3158
10.1074/jbc.M005600200
10.1016/S0065-2776(08)60756-7
10.1084/jem.161.6.1593
10.1074/jbc.M009788200
V. L. Herzberg, K. A. Smith, T cell growth without serum. J. Immunol. 139, 998-1004 (1987). (10.4049/jimmunol.139.4.998) / J. Immunol. (1987)
10.1074/jbc.M100037200
10.1111/j.1432-1033.1997.t01-2-00527.x
S. Mohapatra W. J. Pledger unpublished data.
10.1073/pnas.89.10.4549
10.1016/0092-8674(91)90038-Z
10.1101/gad.7.12a.2378
10.1016/S0898-6568(00)00104-2
10.1289/ehp.9088251

Dates

Type	When
Created	22 years, 3 months ago (May 9, 2003, 8:47 p.m.)
Deposited	1 year, 7 months ago (Jan. 16, 2024, 11:59 a.m.)
Indexed	2 months ago (July 1, 2025, 9:48 a.m.)
Issued	23 years, 3 months ago (May 28, 2002)
Published	23 years, 3 months ago (May 28, 2002)
Published Print	23 years, 3 months ago (May 28, 2002)

Funders 0

None

BibTeX

@article{Olashaw_2002, title={Paradigms of Growth Control: Relation to Cdk Activation}, volume={2002}, ISSN={1525-8882}, url={http://dx.doi.org/10.1126/stke.2002.134.re7}, DOI={10.1126/stke.2002.134.re7}, number={134}, journal={Science’s STKE}, publisher={American Association for the Advancement of Science (AAAS)}, author={Olashaw, Nancy and Pledger, W. J.}, year={2002}, month=may }

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