DOI: 10.1126/stke.2002.119.pe6. Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins

Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins

10.1126/stke.2002.119.pe6

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science's STKE (221)

Abstract

Mechanical stresses modulate cell function by either activating or tuning signal transduction pathways. Mechanotransduction, the process by which cells convert mechanical stimuli into a chemical response, occurs both in cells specialized for sensing mechanical cues and in parenchymal cells whose primary function is not mechanosensory. However, common among the various responses to mechanical stress is the importance of direct or indirect connections between the internal cytoskeleton, the extracellular matrix (ECM), and traditional signal transducing molecules. In many instances, these elements converge at focal adhesions, sites of structural attachment between the cytoskeleton and ECM that are anchored by cell surface integrin receptors. Alenghat and Ingber discuss the accumulating evidence for the central role of cytoskeleton, ECM, and integrin-anchored focal adhesions in several mechanotransduction pathways.

Bibliography

Alenghat, F. J., & Ingber, D. E. (2002). Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins. Scienceâs STKE, 2002(119).

Authors 2

Francis J. Alenghat (first)
Donald E. Ingber (additional)

References 31 Referenced 254

10.1146/annurev.physiol.59.1.633
10.1111/j.1469-7793.2000.00101.x
10.1146/annurev.cellbio.12.1.463
10.1146/annurev.neuro.20.1.567
10.1038/35039512
10.1038/35093011
10.1126/science.278.5341.1315
10.1016/S0092-8674(00)00042-8
10.1038/74286
10.1073/pnas.95.5.2515
10.1016/S0006-3495(89)82660-8
10.1073/pnas.141199598
10.1006/jtbi.1999.1014
10.1083/jcb.131.3.791
10.1091/mbc.6.10.1349
10.1016/0955-0674(91)90058-7
10.1016/S0955-0674(97)80125-1
10.1038/35023621
10.1152/ajpcell.2001.280.6.C1475
10.1161/01.RES.80.3.320
10.1152/ajpcell.1998.275.6.C1591
10.1073/pnas.98.3.1042
10.1083/jcb.153.6.1175
10.1152/ajpheart.2001.281.1.H22
10.1074/jbc.273.41.26323
10.1152/ajpheart.2000.278.4.H1285
10.1091/mbc.12.3.685
10.1016/S0092-8674(00)81604-9
10.1016/S0962-8924(00)01906-1
10.1091/mbc.9.11.3179
Supported by NASA grant NAG2.1501 NIH grant CA-45548 and an HHMI Predoctoral Fellowship (F.A.).

Dates

Type	When
Created	22 years, 3 months ago (May 9, 2003, 8:47 p.m.)
Deposited	1 year, 7 months ago (Jan. 16, 2024, 5:39 a.m.)
Indexed	1 day, 12 hours ago (Aug. 31, 2025, 7:26 p.m.)
Issued	23 years, 6 months ago (Feb. 12, 2002)
Published	23 years, 6 months ago (Feb. 12, 2002)
Published Print	23 years, 6 months ago (Feb. 12, 2002)

Funders 0

None

BibTeX

@article{Alenghat_2002, title={Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins}, volume={2002}, ISSN={1525-8882}, url={http://dx.doi.org/10.1126/stke.2002.119.pe6}, DOI={10.1126/stke.2002.119.pe6}, number={119}, journal={Science’s STKE}, publisher={American Association for the Advancement of Science (AAAS)}, author={Alenghat, Francis J. and Ingber, Donald E.}, year={2002}, month=feb }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        31
      ]
    ],
    "date-time": "2025-08-31T23:26:30Z",
    "timestamp": 1756682790698
  },
  "reference-count": 31,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "119",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2002,
        2,
        12
      ]
    ]
  },
  "abstract": "<jats:p>Mechanical stresses modulate cell function by either activating or tuning signal transduction pathways. Mechanotransduction, the process by which cells convert mechanical stimuli into a chemical response, occurs both in cells specialized for sensing mechanical cues and in parenchymal cells whose primary function is not mechanosensory. However, common among the various responses to mechanical stress is the importance of direct or indirect connections between the internal cytoskeleton, the extracellular matrix (ECM), and traditional signal transducing molecules. In many instances, these elements converge at focal adhesions, sites of structural attachment between the cytoskeleton and ECM that are anchored by cell surface integrin receptors. Alenghat and Ingber discuss the accumulating evidence for the central role of cytoskeleton, ECM, and integrin-anchored focal adhesions in several mechanotransduction pathways.</jats:p>",
  "DOI": "10.1126/stke.2002.119.pe6",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        5,
        10
      ]
    ],
    "date-time": "2003-05-10T00:47:47Z",
    "timestamp": 1052527667000
  },
  "source": "Crossref",
  "is-referenced-by-count": 254,
  "title": "Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins",
  "prefix": "10.1126",
  "volume": "2002",
  "author": [
    {
      "given": "Francis J.",
      "family": "Alenghat",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Departments of Pathology and Surgery, Children's Hospital and Harvard Medical School, Enders 1007, 300 Longwood Avenue, Boston, MA 02115, USA."
        }
      ]
    },
    {
      "given": "Donald E.",
      "family": "Ingber",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Departments of Pathology and Surgery, Children's Hospital and Harvard Medical School, Enders 1007, 300 Longwood Avenue, Boston, MA 02115, USA."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_3_1_1_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.physiol.59.1.633"
    },
    {
      "key": "e_1_3_1_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1469-7793.2000.00101.x"
    },
    {
      "key": "e_1_3_1_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.cellbio.12.1.463"
    },
    {
      "key": "e_1_3_1_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.neuro.20.1.567"
    },
    {
      "key": "e_1_3_1_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35039512"
    },
    {
      "key": "e_1_3_1_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35093011"
    },
    {
      "key": "e_1_3_1_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.278.5341.1315"
    },
    {
      "key": "e_1_3_1_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)00042-8"
    },
    {
      "key": "e_1_3_1_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/74286"
    },
    {
      "key": "e_1_3_1_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.95.5.2515"
    },
    {
      "key": "e_1_3_1_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0006-3495(89)82660-8"
    },
    {
      "key": "e_1_3_1_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.141199598"
    },
    {
      "key": "e_1_3_1_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jtbi.1999.1014"
    },
    {
      "key": "e_1_3_1_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.131.3.791"
    },
    {
      "key": "e_1_3_1_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.6.10.1349"
    },
    {
      "key": "e_1_3_1_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0955-0674(91)90058-7"
    },
    {
      "key": "e_1_3_1_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0955-0674(97)80125-1"
    },
    {
      "key": "e_1_3_1_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35023621"
    },
    {
      "key": "e_1_3_1_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpcell.2001.280.6.C1475"
    },
    {
      "key": "e_1_3_1_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1161/01.RES.80.3.320"
    },
    {
      "key": "e_1_3_1_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpcell.1998.275.6.C1591"
    },
    {
      "key": "e_1_3_1_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.98.3.1042"
    },
    {
      "key": "e_1_3_1_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.153.6.1175"
    },
    {
      "key": "e_1_3_1_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpheart.2001.281.1.H22"
    },
    {
      "key": "e_1_3_1_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.41.26323"
    },
    {
      "key": "e_1_3_1_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1152/ajpheart.2000.278.4.H1285"
    },
    {
      "key": "e_1_3_1_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.12.3.685"
    },
    {
      "key": "e_1_3_1_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81604-9"
    },
    {
      "key": "e_1_3_1_29_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0962-8924(00)01906-1"
    },
    {
      "key": "e_1_3_1_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.9.11.3179"
    },
    {
      "key": "e_1_3_1_31_2",
      "unstructured": "Supported by NASA grant NAG2.1501 NIH grant CA-45548 and an HHMI Predoctoral Fellowship (F.A.)."
    }
  ],
  "container-title": "Science's STKE",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/stke.2002.119.pe6",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        16
      ]
    ],
    "date-time": "2024-01-16T10:39:51Z",
    "timestamp": 1705401591000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/stke.2002.119.pe6"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2002,
        2,
        12
      ]
    ]
  },
  "references-count": 31,
  "journal-issue": {
    "issue": "119",
    "published-print": {
      "date-parts": [
        [
          2002,
          2,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/stke.2002.119.pe6"
  ],
  "URL": "http://dx.doi.org/10.1126/stke.2002.119.pe6",
  "relation": {},
  "ISSN": [
    "1525-8882"
  ],
  "subject": [],
  "container-title-short": "Sci. STKE",
  "published": {
    "date-parts": [
      [
        2002,
        2,
        12
      ]
    ]
  }
}