DOI: 10.1126/science.aat4346. Single-particle cryo-EM—How did it get here and where will it go

Single-particle cryo-EM—How did it get here and where will it go

10.1126/science.aat4346

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Cryo–electron microscopy, or simply cryo-EM, refers mainly to three very different yet closely related techniques: electron crystallography, single-particle cryo-EM, and electron cryotomography. In the past few years, single-particle cryo-EM in particular has triggered a revolution in structural biology and has become a newly dominant discipline. This Review examines the fascinating story of its start and evolution over the past 40-plus years, delves into how and why the recent technological advances have been so groundbreaking, and briefly considers where the technique may be headed in the future.

Bibliography

Cheng, Y. (2018). Single-particle cryo-EMâHow did it get here and where will it go. Science, 361(6405), 876â880.

Authors 1

Yifan Cheng (first)

References 66 Referenced 374

Dates

Type	When
Created	6 years, 11 months ago (Aug. 30, 2018, 2:07 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 6:31 p.m.)
Indexed	2 days, 21 hours ago (Aug. 20, 2025, 8:42 a.m.)
Issued	6 years, 11 months ago (Aug. 31, 2018)
Published	6 years, 11 months ago (Aug. 31, 2018)
Published Print	6 years, 11 months ago (Aug. 31, 2018)

Funders 8

National Institutes of Health 10.13039/100000002
Region: Americas
gov (National government)
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BibTeX

@article{Cheng_2018, title={Single-particle cryo-EM—How did it get here and where will it go}, volume={361}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.aat4346}, DOI={10.1126/science.aat4346}, number={6405}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Cheng, Yifan}, year={2018}, month=aug, pages={876–880} }

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