DOI: 10.1126/science.aaf9620. An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation

An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation

10.1126/science.aaf9620

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Maturation and inhibition of HIV-1 HIV-1 undergoes a two-step assembly process controlled largely by a single region of its Gag protein. Schur et al. determined a complete atomic model for this region within an assembled Gag protein lattice using cryo-electron tomography together with subtomogram averaging. Amino acids from different parts of multiple Gag molecules come together to form an intricate network of interactions that drive HIV-1 assembly. The final step of maturation into the infectious HIV-1 virus is controlled by structural changes in Gag that alter the accessibility of the final cleavage site to the viral protease. Science , this issue p. 506

Bibliography

Schur, F. K. M., Obr, M., Hagen, W. J. H., Wan, W., Jakobi, A. J., Kirkpatrick, J. M., Sachse, C., KrÃ¤usslich, H.-G., & Briggs, J. A. G. (2016). An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation. Science, 353(6298), 506â508.

Authors 9

Florian K. M. Schur (first)
Martin Obr (additional)
Wim J. H. Hagen (additional)
William Wan (additional)
Arjen J. Jakobi (additional)
Joanna M. Kirkpatrick (additional)
Carsten Sachse (additional)
Hans-Georg Kräusslich (additional)
John A. G. Briggs (additional)

References 58 Referenced 421

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Dates

Type	When
Created	9 years, 1 month ago (July 14, 2016, 11:04 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 11:13 a.m.)
Indexed	1 day, 4 hours ago (Aug. 26, 2025, 2:42 a.m.)
Issued	9 years ago (July 29, 2016)
Published	9 years ago (July 29, 2016)
Published Print	9 years ago (July 29, 2016)

Funders 4

Deutsche Forschungsgemeinschaft 10.13039/501100001659
Region: Europe
gov (National government)
Labels3
1. German Research Association
2. German Research Foundation
3. DFG
Awards2
1. BR 3635/2-1
2. KR 906/7-1
European Molecular Biology Laboratory (EMBL) 10.13039/100013060 European Molecular Biology Laboratory
Region: Europe
gov (Research institutes and centers)
Labels2
1. EMBL Heidelberg
2. EMBL
Chica und Heinz Schaller Stiftung
European Molecular Biology Organization Long-Term Fellowship
Awards1
1. ALTF 748-2014

BibTeX

@article{Schur_2016, title={An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation}, volume={353}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.aaf9620}, DOI={10.1126/science.aaf9620}, number={6298}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Schur, Florian K. M. and Obr, Martin and Hagen, Wim J. H. and Wan, William and Jakobi, Arjen J. and Kirkpatrick, Joanna M. and Sachse, Carsten and Kräusslich, Hans-Georg and Briggs, John A. G.}, year={2016}, month=jul, pages={506–508} }

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