DOI: 10.1126/science.aaf5316. The 3.8 Å resolution cryo-EM structure of Zika virus

The 3.8 Å resolution cryo-EM structure of Zika virus

10.1126/science.aaf5316

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Unveiling the Zika virus The ongoing Zika virus epidemic is of grave concern because of its apparent links to congenital microcephaly and Guillain-Barré syndrome. Sirohi et al. present a near-atomic-resolution structure of mature Zika virus determined by cryo-electron microscopy. The structure is mainly similar to that of other flaviviruses such as dengue virus; however, there are differences in a region that may be involved in binding to host receptors. The structure provides a foundation for analysis of the antigenicity and pathogenesis of Zika virus. Science , this issue p. 467

Bibliography

Sirohi, D., Chen, Z., Sun, L., Klose, T., Pierson, T. C., Rossmann, M. G., & Kuhn, R. J. (2016). The 3.8 Ã resolution cryo-EM structure of Zika virus. Science, 352(6284), 467â470.

Authors 7

Devika Sirohi (first)
Zhenguo Chen (additional)
Lei Sun (additional)
Thomas Klose (additional)
Theodore C. Pierson (additional)
Michael G. Rossmann (additional)
Richard J. Kuhn (additional)

References 38 Referenced 651

World Health Organization (WHO) Zika Strategic Response Framework & Joint Operations Plan (January-June 2016) (WHO 2016).
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Dates

Type	When
Created	9 years, 4 months ago (March 31, 2016, 11:45 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 11:51 a.m.)
Indexed	2 days ago (Aug. 21, 2025, 1:41 p.m.)
Issued	9 years, 4 months ago (April 22, 2016)
Published	9 years, 4 months ago (April 22, 2016)
Published Print	9 years, 4 months ago (April 22, 2016)

Funders 2

National Institute of Allergy and Infectious Diseases 10.13039/100000060
Region: Americas
gov (National government)
Labels3
1. Instituto Nacional de Alergias y Enfermedades Infecciosas
2. National Institute of Allergy & Infectious Diseases
3. NIAID
NIH 10.13039/100000002 National Institutes of Health
Region: Americas
gov (National government)
Labels3
1. Institutos Nacionales de la Salud
2. US National Institutes of Health
3. NIH
Awards2
1. R01AI073755
2. R01AI076331

BibTeX

@article{Sirohi_2016, title={The 3.8 Å resolution cryo-EM structure of Zika virus}, volume={352}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.aaf5316}, DOI={10.1126/science.aaf5316}, number={6284}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Sirohi, Devika and Chen, Zhenguo and Sun, Lei and Klose, Thomas and Pierson, Theodore C. and Rossmann, Michael G. and Kuhn, Richard J.}, year={2016}, month=apr, pages={467–470} }

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