DOI: 10.1126/science.aaf0643. Molecular architecture of the inner ring scaffold of the human nuclear pore complex

Molecular architecture of the inner ring scaffold of the human nuclear pore complex

10.1126/science.aaf0643

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Blueprint for a macromolecular machine Nuclear pore complexes (NPCs) consist of around 1000 protein subunits, are embedded in the membrane that surrounds the nucleus, and regulate transport between the nucleus and the cytoplasm. Although the overall shape of NPCs is known, the details of this macromolecular complex have been obscure. Now, Lin et al. have reconstituted the pore components, determined the interactions between them, and fitted them into a tomographic reconstruction. Kosinski et al. have provided an architectural map of the inner ring of the pore. Science , this issue pp. 10.1126/science.aaf1015 and 363

Bibliography

Kosinski, J., Mosalaganti, S., von Appen, A., Teimer, R., DiGuilio, A. L., Wan, W., Bui, K. H., Hagen, W. J. H., Briggs, J. A. G., Glavy, J. S., Hurt, E., & Beck, M. (2016). Molecular architecture of the inner ring scaffold of the human nuclear pore complex. Science, 352(6283), 363â365.

Authors 12

Jan Kosinski (first)
Shyamal Mosalaganti (additional)
Alexander von Appen (additional)
Roman Teimer (additional)
Amanda L. DiGuilio (additional)
William Wan (additional)
Khanh Huy Bui (additional)
Wim J.H. Hagen (additional)
John A. G. Briggs (additional)
Joseph S. Glavy (additional)
Ed Hurt (additional)
Martin Beck (additional)

References 33 Referenced 298

Dates

Type	When
Created	9 years, 4 months ago (April 14, 2016, 5:05 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 11:57 a.m.)
Indexed	1 month, 3 weeks ago (July 2, 2025, 8:46 a.m.)
Issued	9 years, 4 months ago (April 15, 2016)
Published	9 years, 4 months ago (April 15, 2016)
Published Print	9 years, 4 months ago (April 15, 2016)

Funders 6

Stevens Institute of Technology
National Institute on Aging (NIA) 10.13039/100000049 National Institute on Aging
Region: Americas
gov (National government)
Labels4
1. U.S. National Institute on Aging
2. The National Institute on Aging
3. NIH NATIONAL INSTITUTE ON AGING
4. NIA
Awards1
1. 1R21AG047433-01
Ignition Grant Initiative from Stevens Institute of Technology
NIA 10.13039/100000049 National Institute on Aging
Region: Americas
gov (National government)
Labels4
1. U.S. National Institute on Aging
2. The National Institute on Aging
3. NIH NATIONAL INSTITUTE ON AGING
4. NIA
Awards1
1. 1R21AG047433-01
EMBL 10.13039/100013060 European Molecular Biology Laboratory
Region: Europe
gov (Research institutes and centers)
Labels2
1. EMBL Heidelberg
2. EMBL
European Research Council 10.13039/100010663 H2020 European Research Council
Region: Europe
gov (National government)
Labels17
1. H2020 Excellent Science - European Research Council
2. European Research Council
3. H2020 Wissenschaftsexzellenz - Für das Einzelziel 'Europäischer Forschungsrat (ERC)'
4. H2020 Ciencia Excelente - Consejo Europeo de Investigación (CEI)
5. H2020 Excellence Scientifique - Conseil européen de la recherche (CER)
6. H2020 Eccellenza Scientifica - Consiglio europeo della ricerca (CER)
7. H2020 Doskonała Baza Naukowa - Europejska Rada ds. Badań Naukowych (ERBN)
8. EXCELLENT SCIENCE - European Research Council
9. WISSENSCHAFTSEXZELLENZ - Für das Einzelziel 'Europäischer Forschungsrat
10. CIENCIA EXCELENTE - Consejo Europeo de Investigación
11. EXCELLENCE SCIENTIFIQUE - Conseil européen de la recherche
12. ECCELLENZA SCIENTIFICA - Consiglio europeo della ricerca
13. DOSKONAŁA BAZA NAUKOWA - Europejska Rada ds. Badań Naukowych
14. ERC
15. CEI
16. CER
17. ERBN
Awards1
1. 309271-NPCAtlas

BibTeX

@article{Kosinski_2016, title={Molecular architecture of the inner ring scaffold of the human nuclear pore complex}, volume={352}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.aaf0643}, DOI={10.1126/science.aaf0643}, number={6283}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Kosinski, Jan and Mosalaganti, Shyamal and von Appen, Alexander and Teimer, Roman and DiGuilio, Amanda L. and Wan, William and Bui, Khanh Huy and Hagen, Wim J.H. and Briggs, John A. G. and Glavy, Joseph S. and Hurt, Ed and Beck, Martin}, year={2016}, month=apr, pages={363–365} }

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