DOI: 10.1126/science.aac7629. Structure of a yeast spliceosome at 3.6-angstrom resolution

Structure of a yeast spliceosome at 3.6-angstrom resolution

10.1126/science.aac7629

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Structure and function of the spliceosome When RNA is transcribed from DNA in the eukaryotic cell nucleus, the initial transcript includes noncoding introns that must be spliced out. This splicing is done by a complex macromolecular machine, the spliceosome, which comprises five small nuclear RNAs and more than 100 associated proteins. Now, two papers reveal insights into the structure and function of the yeast spliceosome. Yan et al. describe a high-resolution structure determined by electron microscopy of a spliceosome complex comprising four RNAs and 37 proteins. Hang et al. focus on the catalytic site and show how protein components anchor the transcribed RNA and allow sufficient flexibility to deliver RNA components involved in catalyzing the splicing reaction. Science , this issue pp. 1182 and 1191

Bibliography

Yan, C., Hang, J., Wan, R., Huang, M., Wong, C. C. L., & Shi, Y. (2015). Structure of a yeast spliceosome at 3.6-angstrom resolution. Science, 349(6253), 1182â1191.

Authors 6

Chuangye Yan (first)
Jing Hang (additional)
Ruixue Wan (additional)
Min Huang (additional)
Catherine C. L. Wong (additional)
Yigong Shi (additional)

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Dates

Type	When
Created	10 years ago (Aug. 20, 2015, 10:24 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 11:18 a.m.)
Indexed	1 week ago (Aug. 22, 2025, 12:54 a.m.)
Issued	9 years, 11 months ago (Sept. 11, 2015)
Published	9 years, 11 months ago (Sept. 11, 2015)
Published Print	9 years, 11 months ago (Sept. 11, 2015)

Funders 2

National Natural Science Foundation of China 10.13039/501100001809
Region: Asia
gov (National government)
Labels11
1. Chinese National Science Foundation
2. Natural Science Foundation of China
3. National Science Foundation of China
4. NNSF of China
5. NSF of China
6. 国家自然科学基金委员会
7. National Nature Science Foundation of China
8. Guójiā Zìrán Kēxué Jījīn Wěiyuánhuì
9. NSFC
10. NNSF
11. NNSFC
Awards2
1. 31321062
2. 31130002
China's Ministry of Science and Technology 10.13039/501100002855 Ministry of Science and Technology of the People's Republic of China
Region: Asia
gov (National government)
Labels6
1. Chinese Ministry of Science and Technology
2. Ministry of Science & Technology, People Republic of China
3. 中华人民共和国科学技术部
4. Ministry of Science and Technology (China)
5. State Science and Technology Commission
6. MOST
Awards1
1. 2014ZX09507003006

BibTeX

@article{Yan_2015, title={Structure of a yeast spliceosome at 3.6-angstrom resolution}, volume={349}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.aac7629}, DOI={10.1126/science.aac7629}, number={6253}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Yan, Chuangye and Hang, Jing and Wan, Ruixue and Huang, Min and Wong, Catherine C. L. and Shi, Yigong}, year={2015}, month=sep, pages={1182–1191} }

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