DOI: 10.1126/science.aaa5936. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

10.1126/science.aaa5936

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Retroviral capsids in their native form Capsid proteins of retroviruses form protective lattices around viral RNA molecules. The precise molecular details of how individual, full-length capsid proteins assemble to shield the viral genome; however, are not well understood. Obal et al. and Gres et al. now report high resolution crystal structures of the full length capsid proteins from Bovine Leukemia Virus and HIV-1, respectively. The two studies complement each other to reveal the dynamic nature of capsid protein assembly and of how individual capsid proteins interact in the lattice. The findings may have relevance for drug design. Science , this issue p. 95 ; see also p. 99

Bibliography

Gres, A. T., Kirby, K. A., KewalRamani, V. N., Tanner, J. J., Pornillos, O., & Sarafianos, S. G. (2015). X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability. Science, 349(6243), 99â103.

Authors 6

Anna T. Gres (first)
Karen A. Kirby (additional)
Vineet N. KewalRamani (additional)
John J. Tanner (additional)
Owen Pornillos (additional)
Stefan G. Sarafianos (additional)

References 49 Referenced 234

Dates

Type	When
Created	10 years, 2 months ago (June 4, 2015, 11:36 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 12:15 p.m.)
Indexed	16 minutes ago (Aug. 29, 2025, 3:39 p.m.)
Issued	10 years, 1 month ago (July 3, 2015)
Published	10 years, 1 month ago (July 3, 2015)
Published Print	10 years, 1 month ago (July 3, 2015)

Funders 1

NIH 10.13039/100000002 National Institutes of Health
Region: Americas
gov (National government)
Labels3
1. Institutos Nacionales de la Salud
2. US National Institutes of Health
3. NIH
Awards7
1. GM066087
2. AI099284
3. AI112417
4. AI076119
5. AI120860
6. AI100890
7. GM103368

BibTeX

@article{Gres_2015, title={X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability}, volume={349}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.aaa5936}, DOI={10.1126/science.aaa5936}, number={6243}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Gres, Anna T. and Kirby, Karen A. and KewalRamani, Vineet N. and Tanner, John J. and Pornillos, Owen and Sarafianos, Stefan G.}, year={2015}, month=jul, pages={99–103} }

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