DOI: 10.1126/science.943847. Two Functional Effects of Decreased Conductance EPSP's: Synaptic Augmentation and Increased Electrotonic Coupling

Two Functional Effects of Decreased Conductance EPSP's: Synaptic Augmentation and Increased Electrotonic Coupling

10.1126/science.943847

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Three electronically coupled motor neurons, which mediate inking behavior in Aplysia californica , receive both increased and decreased conductance excitatory postsynaptic potentials (EPSP's). The increased conductance EPSP's reduce electrical coupling among the cells, whereas the decreased conductance EPSP's increase electrical coupling. The decreased conductance EPSP's also augment the action of a previously ineffective sensory input and this augmentation is enhanced by the increase in electrical coupling. Both effects combine to trigger a stereotypic behavioral response.

Bibliography

Carew, T. J., & Kandel, E. R. (1976). Two Functional Effects of Decreased Conductance EPSPâs: Synaptic Augmentation and Increased Electrotonic Coupling. Science, 192(4235), 150â153.

Authors 2

Thomas J. Carew (first)
Eric R. Kandel (additional)

References 15 Referenced 52

BENNETT, M. V. L., PHYSIOLOGY OF ELECTROTONIC JUNCTIONS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 137: 509 (1966). (10.1111/j.1749-6632.1966.tb50178.x) / ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (1966)
BENNETT, M. V. L., JOURNAL OF NEUROPHYSIOLOGY 33: 585 (1970). (10.1152/jn.1970.33.5.585) / JOURNAL OF NEUROPHYSIOLOGY (1970)
CAREW, T.J., MEDIATION OF INKING BEHAVIOR IN APLYSIA-CALIFORNICA BY AN IDENTIFIED NEURON IN ABDOMINAL GANGLION, FEDERATION PROCEEDINGS 32: 368 (1973). / FEDERATION PROCEEDINGS (1973)
Carew T. J. in preparation.
CASTELLUCCI, V.F., QUANTAL ANALYSIS OF HETEROSYNAPTIC FACILITATION UNDERLYING DISHABITUATION IN APLYSIA, FEDERATION PROCEEDINGS 34: 418 (1975). / FEDERATION PROCEEDINGS (1975)
Eccles J. C. The Physiology of Synapses (1964). (10.1007/978-3-642-64950-9)
FATT, P, AN ANALYSIS OF THE END-PLATE POTENTIAL RECORDED WITH AN INTRA-CELLULAR ELECTRODE, JOURNAL OF PHYSIOLOGY-LONDON 115: 320 (1951). (10.1113/jphysiol.1951.sp004675) / JOURNAL OF PHYSIOLOGY-LONDON (1951)
GERSCHENFELD, H.M., CHEMICAL TRANSMISSION IN INVERTEBRATE CENTRAL NERVOUS SYSTEMS AND NEUROMUSCULAR JUNCTIONS, PHYSIOLOGICAL REVIEWS 53: 1 (1973). (10.1152/physrev.1973.53.1.1) / PHYSIOLOGICAL REVIEWS (1973)
KATER, S.B., FEEDING IN HELISOMA-TRIVOLVIS - MORPHOLOGICAL AND PHYSIOLOGICAL BASES OF A FIXED ACTION PATTERN, AMERICAN ZOOLOGIST 14: 1017 (1974). (10.1093/icb/14.3.1017) / AMERICAN ZOOLOGIST (1974)
KEHOE, J, IONIC MECHANISMS OF A 2-COMPONENT CHOLINERGIC INHIBITION IN APLYSIA NEURONS, JOURNAL OF PHYSIOLOGY-LONDON 225: 85 (1972). (10.1113/jphysiol.1972.sp009930) / JOURNAL OF PHYSIOLOGY-LONDON (1972)
KUNZE, D.L., INTERNAL POTASSIUM AND CHLORIDE ACTIVITIES AND EFFECTS OF ACETYLCHOLINE ON IDENTIFIABLE APLYSIA NEURONES, NATURE-NEW BIOLOGY 229: 229 (1971). / NATURE-NEW BIOLOGY (1971)
PAUPARDINTRITSC.D, NEURONAL RESPONSES TO 5-HYDROXYTRYPTAMINE RESULTING FROM MEMBRANE-PERMEABILITY DECREASES, NATURE-NEW BIOLOGY 244: 171 (1973). (10.1038/newbio244171a0) / NATURE-NEW BIOLOGY (1973)
SPIRA, M.E., SYNAPTIC CONTROL OF ELECTROTONIC COUPLING BETWEEN NEURONS, BRAIN RESEARCH 37: 294 (1972). (10.1016/0006-8993(72)90674-9) / BRAIN RESEARCH (1972)
Weight, F. F., The Neurosciences, Third Study Program: 929 (1974). / The Neurosciences, Third Study Program (1974)
10.1126/science.170.3959.755

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 11:51 a.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 11:18 a.m.)
Indexed	3 days, 4 hours ago (Sept. 4, 2025, 9:37 a.m.)
Issued	49 years, 4 months ago (April 9, 1976)
Published	49 years, 4 months ago (April 9, 1976)
Published Print	49 years, 4 months ago (April 9, 1976)

Funders 0

None

BibTeX

@article{Carew_1976, title={Two Functional Effects of Decreased Conductance EPSP’s: Synaptic Augmentation and Increased Electrotonic Coupling}, volume={192}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.943847}, DOI={10.1126/science.943847}, number={4235}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Carew, Thomas J. and Kandel, Eric R.}, year={1976}, month=apr, pages={150–153} }

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