DOI: 10.1126/science.918669. Benzodiazepine Receptor: Demonstration in the Central Nervous System

Benzodiazepine Receptor: Demonstration in the Central Nervous System

10.1126/science.918669

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The receptor is mainly localized in the synaptic membrane fraction. Binding to the receptor is stereospecific. Competition for the receptor by various benzodiazepines closely parallels their pharmacological potency.

Bibliography

MÃ¶hler, H., & Okada, T. (1977). Benzodiazepine Receptor: Demonstration in the Central Nervous System. Science, 198(4319), 849â851.

Authors 2

H. Möhler (first)
T. Okada (additional)

References 14 Referenced 1,435

BIGGIO, G, MECHANISMS BY WHICH DIAZEPAM, MUSCIMOL, AND OTHER DRUGS CHANGE CONTENT OF CGMP IN CEREBELLAR CORTEX, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 3592 (1977). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1977)
CURTIS, D.R., BENZODIAZEPINES AND CENTRAL GLYCINE RECEPTORS, BRITISH JOURNAL OF PHARMACOLOGY 56: 307 (1976). (10.1111/j.1476-5381.1976.tb07643.x) / BRITISH JOURNAL OF PHARMACOLOGY (1976)
Haefely, W., Mechanism of Action of Benzodiazepines: 131 (1975). / Mechanism of Action of Benzodiazepines (1975)
MOHLER, H, PROPERTIES OF DIAZEPAM-H-3 BINDING TO BENZODIAZEPINE RECEPTORS IN RAT CEREBRAL-CORTEX, LIFE SCIENCES 20: 2101 (1977). (10.1016/0024-3205(77)90191-6) / LIFE SCIENCES (1977)
MOHLER, H, GABA RECEPTOR-BINDING WITH H-3(+) BICUCULLINE-METHIODIDE IN RAT CNS, NATURE 267: 65 (1977). (10.1038/267065a0) / NATURE (1977)
MULLER, W.E., INTERACTION OF BENZODIAZEPINE DERIVATIVES WITH BOVINE SERUM-ALBUMIN .1. GEL-FILTRATION STUDIES, BIOCHEMICAL PHARMACOLOGY 25: 141 (1976). (10.1016/0006-2952(76)90281-1) / BIOCHEMICAL PHARMACOLOGY (1976)
MULLER, W.E., BENZODIAZEPINES - SPECIFIC COMPETITORS FOR BINDING OF L-TRYPTOPHAN TO HUMAN-SERUM ALBUMIN, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 288: 17 (1975). (10.1007/BF00501811) / NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (1975)
Okada T. in preparation.
Randall, L. O., Psychopharmacological Agents 3: 175 (1974). / Psychopharmacological Agents (1974)
Schwob, R., Journal of Labelled Compounds 14: 355 (1978). / Journal of Labelled Compounds (1978)
SQUIRES, R.F., BENZODIAZEPINE RECEPTORS IN RAT-BRAIN, NATURE 266: 732 (1977). (10.1038/266732a0) / NATURE (1977)
YOUNG, A.B., INTERACTION OF BENZODIAZEPINES WITH CENTRAL NERVOUS GLYCINE RECEPTORS - POSSIBLE MECHANISM OF ACTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 2246 (1974). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1974)
ZBINDEN, G, ADV PHARMACOL 5: 213 (1967). (10.1016/S1054-3589(08)60658-4) / ADV PHARMACOL (1967)
ZUKIN, S.R., GAMMA-AMINOBUTYRIC ACID BINDING TO RECEPTOR-SITES IN RAT CENTRAL NERVOUS-SYSTEM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 4802 (1974). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1974)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 12:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 6:30 a.m.)
Indexed	1 week, 1 day ago (Aug. 20, 2025, 9:22 a.m.)
Issued	47 years, 9 months ago (Nov. 25, 1977)
Published	47 years, 9 months ago (Nov. 25, 1977)
Published Print	47 years, 9 months ago (Nov. 25, 1977)

Funders 0

None

BibTeX

@article{M_hler_1977, title={Benzodiazepine Receptor: Demonstration in the Central Nervous System}, volume={198}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.918669}, DOI={10.1126/science.918669}, number={4319}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Möhler, H. and Okada, T.}, year={1977}, month=nov, pages={849–851} }

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