DOI: 10.1126/science.8469973. Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

10.1126/science.8469973

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Cells maintain the integrity of their genome through an intricate network of repair systems that recognize and remove lesions from DNA. The only known site-directed recombination process in vertebrates is the V(D)J recombination of lymphocyte antigen receptor genes. A large panel of cell lines deficient in DNA repair were tested for the ability to perform V(D)J recombination after introduction of the RAG-1 and RAG-2 genes. Two mutants failed to generate normal V(D)J recombination, and further analysis provided evidence for two distinct nonlymphoid-specific genes that encode factors involved in both DNA repair and V(D)J recombination.

Bibliography

Taccioli, G. E., Rathbun, G., Oltz, E., Stamato, T., Jeggo, P. A., & Alt, F. W. (1993). Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants. Science, 260(5105), 207â210.

Authors 6

Guillermo E. Taccioli (first)
Gary Rathbun (additional)
Eugene Oltz (additional)
Thomas Stamato (additional)
Penny A. Jeggo (additional)
Frederick W. Alt (additional)

References 28 Referenced 354

10.1016/0167-5699(92)90043-7
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 6:29 a.m.)
Indexed	2 days, 2 hours ago (Aug. 24, 2025, 7:01 p.m.)
Issued	32 years, 4 months ago (April 9, 1993)
Published	32 years, 4 months ago (April 9, 1993)
Published Print	32 years, 4 months ago (April 9, 1993)

Funders 0

None

BibTeX

@article{Taccioli_1993, title={Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants}, volume={260}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8469973}, DOI={10.1126/science.8469973}, number={5105}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Taccioli, Guillermo E. and Rathbun, Gary and Oltz, Eugene and Stamato, Thomas and Jeggo, Penny A. and Alt, Frederick W.}, year={1993}, month=apr, pages={207–210} }

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