DOI: 10.1126/science.8438156. Deletion of <i>IRF-1</i> , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

10.1126/science.8438156

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1 , a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromeric to IL-3 and GM-CSF . Among these genes, only IRF-1 was consistently deleted at one or both alleles in 13 cases of leukemia or myelodysplasia with aberrations of 5q31. Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia.

Bibliography

Willman, C. L., Sever, C. E., Pallavicini, M. G., Harada, H., Tanaka, N., Slovak, M. L., Yamamoto, H., Harada, K., Meeker, T. C., List, A. F., & Taniguchi, T. (1993). Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia. Science, 259(5097), 968â971.

Authors 11

Cheryl L. Willman (first)
Cordelia E. Sever (additional)
Maria G. Pallavicini (additional)
Hisashi Harada (additional)
Nobuyuki Tanaka (additional)
Marilyn L. Slovak (additional)
Hitomi Yamamoto (additional)
Kenji Harada (additional)
Timothy C. Meeker (additional)
Alan F. List (additional)
Tadatsugu Taniguchi (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 5:21 a.m.)
Indexed	1 month, 2 weeks ago (July 14, 2025, 11:37 p.m.)
Issued	32 years, 6 months ago (Feb. 12, 1993)
Published	32 years, 6 months ago (Feb. 12, 1993)
Published Print	32 years, 6 months ago (Feb. 12, 1993)

Funders 0

None

BibTeX

@article{Willman_1993, title={Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia}, volume={259}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8438156}, DOI={10.1126/science.8438156}, number={5097}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Willman, Cheryl L. and Sever, Cordelia E. and Pallavicini, Maria G. and Harada, Hisashi and Tanaka, Nobuyuki and Slovak, Marilyn L. and Yamamoto, Hitomi and Harada, Kenji and Meeker, Timothy C. and List, Alan F. and Taniguchi, Tadatsugu}, year={1993}, month=feb, pages={968–971} }

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