Crossref
journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract
The mechanism of interleukin-1 (IL-1) signaling is unknown. Tumor necrosis factor-α uses a signal transduction pathway that involves sphingomyelin hydrolysis to ceramide and stimulation of a ceramide-activated protein kinase. In intact EL4 thymoma cells, IL-1β similarly stimulated a rapid decrease of sphingomyelin and an elevation of ceramide, and enhanced ceramide-activated protein kinase activity. This cascade was also activated by IL-1β in a cell-free system, demonstrating tight coupling to the receptor. Exogenous sphingomyelinase, but not phospholipases A 2 , C, or D, in combination with phorbol ester replaced IL-1β to stimulate IL-2 secretion. Thus, IL-1β signals through the sphingomyelin pathway.
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Dates
| Type | When |
|---|---|
| Created | 18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.) |
| Deposited | 1 year, 7 months ago (Jan. 15, 2024, 5:22 a.m.) |
| Indexed | 2 months ago (June 25, 2025, 7:49 p.m.) |
| Issued | 32 years, 7 months ago (Jan. 22, 1993) |
| Published | 32 years, 7 months ago (Jan. 22, 1993) |
| Published Print | 32 years, 7 months ago (Jan. 22, 1993) |
@article{Mathias_1993, title={Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β}, volume={259}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8424175}, DOI={10.1126/science.8424175}, number={5094}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Mathias, Shalini and Younes, Anas and Kan, Chu-Cheng and Orlow, Irene and Joseph, Cecil and Kolesnick, Richard N.}, year={1993}, month=jan, pages={519–522} }