DOI: 10.1126/science.841307. Acute Systemic Effects of Cocaine in Man: A Controlled Study by Intranasal and Intravenous Routes

Acute Systemic Effects of Cocaine in Man: A Controlled Study by Intranasal and Intravenous Routes

10.1126/science.841307

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Nineteen healthy volunteer subjects who regularly administered cocaine to themselves were given placebo and 10 and 25 milligrams of cocaine hydrochloride intravenously and intranasally. A dose of 100 milligrams of cocaine was administered only by the intranasal route. By this route 10 milligrams of cocaine produced no changes different from placebo, and 25 milligrams of cocaine produced physiologic changes only in systolic blood pressure. The 100-milligram dose given intranasally and all of the doses given intravenously produced significant dose-related physiologic and subjective responses.

Bibliography

Resnick, R. B., Kestenbaum, R. S., & Schwartz, L. K. (1977). Acute Systemic Effects of Cocaine in Man: A Controlled Study by Intranasal and Intravenous Routes. Science, 195(4279), 696â698.

Authors 3

Richard B. Resnick (first)
Richard S. Kestenbaum (additional)
Lee K. Schwartz (additional)

References 8 Referenced 210

ABELSON H.I. PUBLIC EXPERIENCE PS (1975).
FISCHMAN, M.W., CARDIOVASCULAR AND SUBJECTIVE EFFECTS OF INTRAVENOUS COCAINE ADMINISTRATION IN HUMANS, ARCHIVES OF GENERAL PSYCHIATRY 33: 983 (1976). (10.1001/archpsyc.1976.01770080101010) / ARCHIVES OF GENERAL PSYCHIATRY (1976)
GOSSETT, J.T., EXTENT AND PREVALENCE OF ILLICIT DRUG USE AS REPORTED BY 56,745 STUDENTS, JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 216: 1464 (1971). (10.1001/jama.1971.03180350042010) / JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (1971)
HILL, H.E., THE ADDICTION RESEARCH-CENTER INVENTORY - APPENDIX .1. ITEMS COMPRISING EMPIRICAL SCALES FOR 7 DRUGS .2. ITEMS WHICH DO NOT DIFFERENTIATE PLACEBO FROM ANY DRUG CONDITION, PSYCHOPHARMACOLOGIA 4: 184 (1963). (10.1007/BF02584090) / PSYCHOPHARMACOLOGIA (1963)
ODONNEL J.A. NIDA5 NAT I DRUG AB (1976).
POST, R.M., EFFECTS OF COCAINE ON DEPRESSED-PATIENTS, AMERICAN JOURNAL OF PSYCHIATRY 131: 511 (1974). (10.1176/ajp.131.5.511) / AMERICAN JOURNAL OF PSYCHIATRY (1974)
RITCHIE, J.M., PHARMACOL BASIS THER: 379 (1975). / PHARMACOL BASIS THER (1975)
10.1126/science.56036

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 12:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 6:33 a.m.)
Indexed	19 hours, 33 minutes ago (Sept. 4, 2025, 10:02 a.m.)
Issued	48 years, 6 months ago (Feb. 18, 1977)
Published	48 years, 6 months ago (Feb. 18, 1977)
Published Print	48 years, 6 months ago (Feb. 18, 1977)

Funders 0

None

BibTeX

@article{Resnick_1977, title={Acute Systemic Effects of Cocaine in Man: A Controlled Study by Intranasal and Intravenous Routes}, volume={195}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.841307}, DOI={10.1126/science.841307}, number={4279}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Resnick, Richard B. and Kestenbaum, Richard S. and Schwartz, Lee K.}, year={1977}, month=feb, pages={696–698} }

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