DOI: 10.1126/science.8397445. A Common Nuclear Signal Transduction Pathway Activated by Growth Factor and Cytokine Receptors

A Common Nuclear Signal Transduction Pathway Activated by Growth Factor and Cytokine Receptors

10.1126/science.8397445

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Growth factors and cytokines act through cell surface receptors with different biochemical properties. Yet each type of receptor can elicit similar as well as distinct biological responses in target cells, suggesting that distinct classes of receptors activate common gene sets. Epidermal growth factor, interferon-γ, and interleukin-6 all activated, through direct tyrosine phosphorylation, latent cytoplasmic transcription factors that recognized similar DNA elements. However, different ligands activated different patterns of factors with distinct DNA-binding specificities in the same and different cells. Thus, unrelated receptors may activate a common nuclear signal transduction pathway that, through differential use of latent cytoplasmic proteins, permits these receptors to regulate both common and unique sets of genes.

Bibliography

Sadowski, H. B., Shuai, K., Darnell, J. E., & Gilman, M. Z. (1993). A Common Nuclear Signal Transduction Pathway Activated by Growth Factor and Cytokine Receptors. Science, 261(5129), 1739â1744.

Authors 4

Henry B. Sadowski (first)
Ke Shuai (additional)
James E. Darnell (additional)
Michael Z. Gilman (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 6:18 a.m.)
Indexed	1 month, 3 weeks ago (July 11, 2025, 6:26 a.m.)
Issued	31 years, 11 months ago (Sept. 24, 1993)
Published	31 years, 11 months ago (Sept. 24, 1993)
Published Print	31 years, 11 months ago (Sept. 24, 1993)

Funders 0

None

BibTeX

@article{Sadowski_1993, title={A Common Nuclear Signal Transduction Pathway Activated by Growth Factor and Cytokine Receptors}, volume={261}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8397445}, DOI={10.1126/science.8397445}, number={5129}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Sadowski, Henry B. and Shuai, Ke and Darnell, James E. and Gilman, Michael Z.}, year={1993}, month=sep, pages={1739–1744} }

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