DOI: 10.1126/science.8389056. Neuroprotective Effects of Glutamate Antagonists and Extracellular Acidity

Neuroprotective Effects of Glutamate Antagonists and Extracellular Acidity

10.1126/science.8389056

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Glutamate antagonists protect neurons from hypoxic injury both in vivo and in vitro, but in vitro studies have not been done under the acidic conditions typical of hypoxia-ischemia in vivo. Consistent with glutamate receptor antagonism, extracellular acidity reduced neuronal death in murine cortical cultures that were deprived of oxygen and glucose. Under these acid conditions, N -methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate-kainate antagonists further reduced neuronal death, such that some neurons tolerated prolonged oxygen and glucose deprivation almost as well as did astrocytes. Neuroprotection induced by this combination exceeded that induced by glutamate antagonists alone, suggesting that extracellular acidity has beneficial effects beyond the attenuation of ionotropic glutamate receptor activation.

Bibliography

Kaku, D. A., Giffard, R. G., & Choi, D. W. (1993). Neuroprotective Effects of Glutamate Antagonists and Extracellular Acidity. Science, 260(5113), 1516â1518.

Authors 3

David A. Kaku (first)
Rona G. Giffard (additional)
Dennis W. Choi (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 6:24 a.m.)
Indexed	54 minutes ago (Sept. 2, 2025, 11:51 a.m.)
Issued	32 years, 2 months ago (June 4, 1993)
Published	32 years, 2 months ago (June 4, 1993)
Published Print	32 years, 2 months ago (June 4, 1993)

Funders 0

None

BibTeX

@article{Kaku_1993, title={Neuroprotective Effects of Glutamate Antagonists and Extracellular Acidity}, volume={260}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8389056}, DOI={10.1126/science.8389056}, number={5113}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Kaku, David A. and Giffard, Rona G. and Choi, Dennis W.}, year={1993}, month=jun, pages={1516–1518} }

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