DOI: 10.1126/science.8378774. Induction by EGF and Interferon-γ of Tyrosine Phosphorylated DNA Binding Proteins in Mouse Liver Nuclei

Induction by EGF and Interferon-γ of Tyrosine Phosphorylated DNA Binding Proteins in Mouse Liver Nuclei

10.1126/science.8378774

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Intraperitoneal injection of epidermal growth factor (EGF) into mice resulted in the appearance in liver nuclei of three tyrosine phosphorylated proteins (84, 91, and 92 kilodaltons) within minutes after administration of EGF. Administration of interferon-γ (IFN-γ) resulted in the appearance in liver nuclei of two tyrosine phosphorylated proteins (84 and 91 kilodaltons). The 84- and 91-kilodalton proteins detected after either EGF or IFN-γ administration were identified as the IFN-γ activation factors (GAF). Furthermore, gel shift analysis revealed that these GAF proteins, detected after either EGF or IFN-γ administration, specifically bound to the sis-inducible element of the c- fos promoter. Thus, GAF proteins participate in nuclear signaling in both IFN-γ and EGF pathways.

Bibliography

Ruff-Jamison, S., Chen, K., & Cohen, S. (1993). Induction by EGF and Interferon-Î³ of Tyrosine Phosphorylated DNA Binding Proteins in Mouse Liver Nuclei. Science, 261(5129), 1733â1736.

Authors 3

Susan Ruff-Jamison (first)
Katherine Chen (additional)
Stanley Cohen (additional)

References 28 Referenced 214

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CARPENTER, G, RECEPTOR TYROSINE KINASE SUBSTRATES - SRC HOMOLOGY DOMAINS AND SIGNAL TRANSDUCTION, FASEB JOURNAL 6: 3283 (1992). (10.1096/fasebj.6.14.1385243) / FASEB JOURNAL (1992)
CARPENTER, G, EPIDERMAL GROWTH-FACTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 265: 7709 (1990). (10.1016/S0021-9258(19)38983-5) / JOURNAL OF BIOLOGICAL CHEMISTRY (1990)
Carpenter, G., Peptide Growth Factors and Their Receptors: 69 (1990). / Peptide Growth Factors and Their Receptors (1990)
DAVID, M, INVITRO ACTIVATION OF THE TRANSCRIPTION FACTOR ISGF3 BY INTERFERON-ALPHA INVOLVES A MEMBRANE-ASSOCIATED TYROSINE PHOSPHATASE AND TYROSINE KINASE, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 6593 (1993). (10.1016/S0021-9258(18)53292-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1993)
DECKER, T, CYTOPLASMIC ACTIVATION OF GAF, AN IFN-GAMMA-REGULATED DNA-BINDING FACTOR, EMBO JOURNAL 10: 927 (1991). (10.1002/j.1460-2075.1991.tb08026.x) / EMBO JOURNAL (1991)
DONALDSON, R.W., EPIDERMAL GROWTH-FACTOR STIMULATES TYROSINE PHOSPHORYLATION IN THE NEONATAL MOUSE - ASSOCIATION OF A M(R) 55,000 SUBSTRATE WITH THE RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 8477 (1992). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1992)
FISHER, D.A., METABOLISM AND EFFECTS OF EPIDERMAL GROWTH-FACTOR AND RELATED GROWTH-FACTORS IN MAMMALS, ENDOCRINE REVIEWS 11: 418 (1990). (10.1210/edrv-11-3-418) / ENDOCRINE REVIEWS (1990)
10.1016/0092-8674(92)90106-M
FU, X.Y., ISGF3, THE TRANSCRIPTIONAL ACTIVATOR INDUCED BY INTERFERON-ALPHA, CONSISTS OF MULTIPLE INTERACTING POLYPEPTIDE-CHAINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 8555 (1990). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1990)
FU, X.Y., THE PROTEINS OF ISGF-3, THE INTERFERON ALPHA-INDUCED TRANSCRIPTIONAL ACTIVATOR, DEFINE A GENE FAMILY INVOLVED IN SIGNAL TRANSDUCTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 7840 (1992). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1992)
GLENNEY, J.R., TYROSINE-PHOSPHORYLATED PROTEINS - MEDIATORS OF SIGNAL TRANSDUCTION FROM THE TYROSINE KINASES, BIOCHIMICA ET BIOPHYSICA ACTA 1134: 113 (1992). (10.1016/0167-4889(92)90034-9) / BIOCHIMICA ET BIOPHYSICA ACTA (1992)
GUTCH, M.J., TYROSINE PHOSPHORYLATION IS REQUIRED FOR ACTIVATION OF AN ALPHA-INTERFERON-STIMULATED TRANSCRIPTION FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 11411 (1992). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1992)
HAYES, T.E., INDUCIBLE BINDING OF A FACTOR TO THE C-FOS REGULATORY REGION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 1272 (1987). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1987)
HUNTER, T, CURR OPIN CELL BIOL 1: 1168 (1989). (10.1016/S0955-0674(89)80068-7) / CURR OPIN CELL BIOL (1989)
IGARASHI, K, INVITRO ACTIVATION OF THE TRANSCRIPTION FACTOR GAMMA-INTERFERON ACTIVATION FACTOR BY GAMMA-INTERFERON - EVIDENCE FOR A TYROSINE PHOSPHATASE KINASE SIGNALING CASCADE, MOLECULAR AND CELLULAR BIOLOGY 13: 1634 (1993). / MOLECULAR AND CELLULAR BIOLOGY (1993)
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LAURENCE, D. J. R., TUMOR BIOLOGY 11: 229 (1990). (10.1159/000217659) / TUMOR BIOLOGY (1990)
LEVY, D, NEW BIOL 2: 923 (1990). / NEW BIOL (1990)
MASMOUDI, A, PROTEIN KINASE-C LOCATED IN RAT-LIVER NUCLEI - PARTIAL-PURIFICATION AND BIOCHEMICAL AND IMMUNOCHEMICAL CHARACTERIZATION, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 1172 (1989). (10.1016/S0021-9258(19)85068-8) / JOURNAL OF BIOLOGICAL CHEMISTRY (1989)
RUFFJAMISON, S, EPIDERMAL GROWTH-FACTOR STIMULATES THE TYROSINE PHOSPHORYLATION OF SHC IN THE MOUSE, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 7610 (1993). (10.1016/S0021-9258(18)52996-3) / JOURNAL OF BIOLOGICAL CHEMISTRY (1993)
RUFFJAMISON, S, MOLECULAR MODELING AND SITE-DIRECTED MUTAGENESIS OF AN ANTI-PHOSPHOTYROSINE ANTIBODY PREDICTS THE COMBINING SITE AND ALLOWS THE DETECTION OF HIGHER AFFINITY INTERACTIONS, PROTEIN ENGINEERING 6: 661 (1993). (10.1093/protein/6.6.661) / PROTEIN ENGINEERING (1993)
RUFFJAMISON S unpublished data.
SADOWSKI, H.B., CELL-FREE ACTIVATION OF A DNA-BINDING PROTEIN BY EPIDERMAL GROWTH-FACTOR, NATURE 362: 79 (1993). (10.1038/362079a0) / NATURE (1993)
10.1126/science.1281555
10.1016/0092-8674(90)90801-K
WAGNER, B.J., THE SIF BINDING-ELEMENT CONFERS SIS/PDGF INDUCIBILITY ONTO THE C-FOS PROMOTER, EMBO JOURNAL 9: 4477 (1990). (10.1002/j.1460-2075.1990.tb07898.x) / EMBO JOURNAL (1990)
YARDEN, Y, GROWTH-FACTOR RECEPTOR TYROSINE KINASES, ANNUAL REVIEW OF BIOCHEMISTRY 57: 443 (1988). (10.1146/annurev.bi.57.070188.002303) / ANNUAL REVIEW OF BIOCHEMISTRY (1988)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 6:17 a.m.)
Indexed	4 months ago (April 22, 2025, 3:13 a.m.)
Issued	31 years, 11 months ago (Sept. 24, 1993)
Published	31 years, 11 months ago (Sept. 24, 1993)
Published Print	31 years, 11 months ago (Sept. 24, 1993)

Funders 0

None

BibTeX

@article{Ruff_Jamison_1993, title={Induction by EGF and Interferon-γ of Tyrosine Phosphorylated DNA Binding Proteins in Mouse Liver Nuclei}, volume={261}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8378774}, DOI={10.1126/science.8378774}, number={5129}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Ruff-Jamison, Susan and Chen, Katherine and Cohen, Stanley}, year={1993}, month=sep, pages={1733–1736} }

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      "date-parts": [
        [
          1993,
          9,
          24
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.8378774"
  ],
  "URL": "http://dx.doi.org/10.1126/science.8378774",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1993,
        9,
        24
      ]
    ]
  }
}