DOI: 10.1126/science.8332901. Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

10.1126/science.8332901

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The cytoplasmic tyrosine kinase, Bruton's tyrosine kinase (Btk, formerly bpk or atk), is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells. In the murine X-linked immunodeficiency (XID), B cells are present but respond abnormally to activating signals. The Btk gene, btk , was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis. A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions.

Bibliography

Rawlings, D. J., Saffran, D. C., Tsukada, S., Largaespada, D. A., Grimaldi, J. C., Cohen, L., Mohr, R. N., Bazan, J. F., Howard, M., Copeland, N. G., Jenkins, N. A., & Witte, O. N. (1993). Mutation of Unique Region of Brutonâs Tyrosine Kinase in Immunodeficient XID Mice. Science, 261(5119), 358â361.

Authors 12

David J. Rawlings (first)
Douglas C. Saffran (additional)
Satoshi Tsukada (additional)
David A. Largaespada (additional)
J. Christopher Grimaldi (additional)
Lucie Cohen (additional)
Randolph N. Mohr (additional)
J. Fernando Bazan (additional)
Maureen Howard (additional)
Neal G. Copeland (additional)
Nancy A. Jenkins (additional)
Owen N. Witte (additional)

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Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 6:26 a.m.)
Indexed	3 days, 1 hour ago (Sept. 3, 2025, 6:12 a.m.)
Issued	32 years, 1 month ago (July 16, 1993)
Published	32 years, 1 month ago (July 16, 1993)
Published Print	32 years, 1 month ago (July 16, 1993)

Funders 0

None

BibTeX

@article{Rawlings_1993, title={Mutation of Unique Region of Bruton’s Tyrosine Kinase in Immunodeficient XID Mice}, volume={261}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8332901}, DOI={10.1126/science.8332901}, number={5119}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Rawlings, David J. and Saffran, Douglas C. and Tsukada, Satoshi and Largaespada, David A. and Grimaldi, J. Christopher and Cohen, Lucie and Mohr, Randolph N. and Bazan, J. Fernando and Howard, Maureen and Copeland, Neal G. and Jenkins, Nancy A. and Witte, Owen N.}, year={1993}, month=jul, pages={358–361} }

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