DOI: 10.1126/science.8266078. Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

10.1126/science.8266078

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The interleukin-2 (IL-2) receptor γ chain (IL-2Rγ) is an essential component of high- and intermediate-affinity IL-2 receptors. IL-2Rγ was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL-2Rγ to augment IL-4 binding affinity, and the requirement for IL-2Rγ in IL-4-mediated phosphorylation of insulin receptor substrate-1. The observation that IL-2Rγ is a functional component of the IL-4 receptor, together with the finding that IL-2Rγ associates with the IL-7 receptor, begins to elucidate why deficiency of this common γ chain (gamma; c ) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

Bibliography

Russell, S. M., Keegan, A. D., Harada, N., Nakamura, Y., Noguchi, M., Leland, P., Friedmann, M. C., Miyajima, A., Puri, R. K., Paul, W. E., & Leonard, W. J. (1993). Interleukin-2 Receptor Î³ Chain: a Functional Component of the Interleukin-4 Receptor. Science, 262(5141), 1880â1883.

Authors 11

Sarah M. Russell (first)
Achsah D. Keegan (additional)
Nobuyuki Harada (additional)
Yoshiaki Nakamura (additional)
Masayuki Noguchi (additional)
Pamela Leland (additional)
Michael C. Friedmann (additional)
Atsushi Miyajima (additional)
Raj K. Puri (additional)
William E. Paul (additional)
Warren J. Leonard (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:05 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 5:46 a.m.)
Indexed	31 minutes ago (Sept. 2, 2025, 4:17 p.m.)
Issued	31 years, 8 months ago (Dec. 17, 1993)
Published	31 years, 8 months ago (Dec. 17, 1993)
Published Print	31 years, 8 months ago (Dec. 17, 1993)

Funders 0

None

BibTeX

@article{Russell_1993, title={Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor}, volume={262}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8266078}, DOI={10.1126/science.8266078}, number={5141}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Russell, Sarah M. and Keegan, Achsah D. and Harada, Nobuyuki and Nakamura, Yoshiaki and Noguchi, Masayuki and Leland, Pamela and Friedmann, Michael C. and Miyajima, Atsushi and Puri, Raj K. and Paul, William E. and Leonard, Warren J.}, year={1993}, month=dec, pages={1880–1883} }

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