DOI: 10.1126/science.8197461. Reversal of Terminal Differentiation Mediated by p107 in Rb <sup>-/-</sup> Muscle Cells

Reversal of Terminal Differentiation Mediated by p107 in Rb -/- Muscle Cells

10.1126/science.8197461

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb -/- ) were induced by serum to reenter the cell cycle. Development of the myogenic phenotype in Rb -/- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb -/- myotubes.

Bibliography

Schneider, J. W., Gu, W., Zhu, L., Mahdavi, V., & Nadal-Ginard, B. (1994). Reversal of Terminal Differentiation Mediated by p107 in Rb -/- Muscle Cells. Science, 264(5164), 1467â1471.

Authors 5

Jay W. Schneider (first)
Wei Gu (additional)
Liang Zhu (additional)
Vijak Mahdavi (additional)
Bernardo Nadal-Ginard (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 12:35 a.m.)
Indexed	4 weeks, 1 day ago (July 30, 2025, 11:20 a.m.)
Issued	31 years, 2 months ago (June 3, 1994)
Published	31 years, 2 months ago (June 3, 1994)
Published Print	31 years, 2 months ago (June 3, 1994)

Funders 0

None

BibTeX

@article{Schneider_1994, title={Reversal of Terminal Differentiation Mediated by p107 in Rb -/- Muscle Cells}, volume={264}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8197461}, DOI={10.1126/science.8197461}, number={5164}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Schneider, Jay W. and Gu, Wei and Zhu, Liang and Mahdavi, Vijak and Nadal-Ginard, Bernardo}, year={1994}, month=jun, pages={1467–1471} }

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