DOI: 10.1126/science.8178172. Short-Range DNA Looping by the <i>Xenopus</i> HMG-Box Transcription Factor, xUBF

Short-Range DNA Looping by the Xenopus HMG-Box Transcription Factor, xUBF

10.1126/science.8178172

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Xenopus UBF (xUBF) interacts with DNA by way of multiple HMG-box domains. When xUBF binds to the ribosomal promoter, the carboxyl-terminal acidic tail and amino-terminal HMG-box interact. Binding also leads to negative DNA supercoiling and the formation of a disk-like structure, the enhancesome. Within the enhancesome, an xUBF dimer makes a low-density protein core around which DNA is looped into a single 180-base pair turn, probably by in-phase bending. The enhancesome structure suggests a mechanism for xUBF-dependent recruitment of the TATA box-binding protein complex without direct interaction between the two factors.

Bibliography

Bazett-Jones, D. P., Leblanc, B., Herfort, M., & Moss, T. (1994). Short-Range DNA Looping by the Xenopus HMG-Box Transcription Factor, xUBF. Science, 264(5162), 1134â1137.

Authors 4

David P. Bazett-Jones (first)
Benoît Leblanc (additional)
Manfred Herfort (additional)
Tom Moss (additional)

References 35 Referenced 161

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 12:30 a.m.)
Indexed	1 month, 2 weeks ago (July 2, 2025, 3:08 p.m.)
Issued	31 years, 3 months ago (May 20, 1994)
Published	31 years, 3 months ago (May 20, 1994)
Published Print	31 years, 3 months ago (May 20, 1994)

Funders 0

None

BibTeX

@article{Bazett_Jones_1994, title={Short-Range DNA Looping by the Xenopus HMG-Box Transcription Factor, xUBF}, volume={264}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8178172}, DOI={10.1126/science.8178172}, number={5162}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Bazett-Jones, David P. and Leblanc, Benoît and Herfort, Manfred and Moss, Tom}, year={1994}, month=may, pages={1134–1137} }

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