DOI: 10.1126/science.8178155. Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

10.1126/science.8178155

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the β chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.

Bibliography

Grabstein, K. H., Eisenman, J., Shanebeck, K., Rauch, C., Srinivasan, S., Fung, V., Beers, C., Richardson, J., Schoenborn, M. A., Ahdieh, M., Johnson, L., Alderson, M. R., Watson, J. D., Anderson, D. M., & Giri, J. G. (1994). Cloning of a T Cell Growth Factor that Interacts with the Î² Chain of the Interleukin-2 Receptor. Science, 264(5161), 965â968.

Authors 15

Kenneth H. Grabstein (first)
June Eisenman (additional)
Kurt Shanebeck (additional)
Charles Rauch (additional)
Subhashini Srinivasan (additional)
Victor Fung (additional)
Courtney Beers (additional)
Jane Richardson (additional)
Michael A. Schoenborn (additional)
Minoo Ahdieh (additional)
Lisabeth Johnson (additional)
Mark R. Alderson (additional)
James D. Watson (additional)
Dirk M. Anderson, (additional)
Judith G. Giri (additional)

References 27 Referenced 1,128

ANDERSON, D.M., MOLECULAR-CLONING OF MAST-CELL GROWTH-FACTOR, A HEMATOPOIETIN THAT IS ACTIVE IN BOTH MEMBRANE-BOUND AND SOLUBLE FORMS, CELL 63: 235 (1990). (10.1016/0092-8674(90)90304-W) / CELL (1990)
BAZAN, J.F., HEMATOPOIETIC RECEPTORS AND HELICAL CYTOKINES, IMMUNOLOGY TODAY 11: 350 (1990). (10.1016/0167-5699(90)90139-Z) / IMMUNOLOGY TODAY (1990)
10.1126/science.1631562
BENVENISTE, E.N., STIMULATION OF OLIGODENDROGLIAL PROLIFERATION AND MATURATION BY INTERLEUKIN-2, NATURE 321: 610 (1986). (10.1038/321610a0) / NATURE (1986)
10.1126/science.3500515
DUNNETT, C.W., A MULTIPLE COMPARISON PROCEDURE FOR COMPARING SEVERAL TREATMENTS WITH A CONTROL, JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION 50: 1096 (1955). (10.1080/01621459.1955.10501294) / JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION (1955)
GILLIS, S, LONG-TERM CULTURE OF TUMOR-SPECIFIC CYTOTOXIC T-CELLS, NATURE 268: 154 (1977). (10.1038/268154a0) / NATURE (1977)
GIRI J COMMUNICATION.
GRABSTEIN K COMMUNICATION.
GRABSTEIN, K, PURIFICATION TO HOMOGENEITY OF B-CELL STIMULATING FACTOR - A MOLECULE THAT STIMULATES PROLIFERATION OF MULTIPLE LYMPHOKINE-DEPENDENT CELL-LINES, JOURNAL OF EXPERIMENTAL MEDICINE 163: 1405 (1986). (10.1084/jem.163.6.1405) / JOURNAL OF EXPERIMENTAL MEDICINE (1986)
GREENBERGER, J.S., INTERLEUKIN 3-DEPENDENT HEMATOPOIETIC PROGENITOR-CELL LINES, FEDERATION PROCEEDINGS 42: 2762 (1983). / FEDERATION PROCEEDINGS (1983)
10.1126/science.8266076
MCMAHAN, C.J., A NOVEL IL-1 RECEPTOR, CLONED FROM B-CELLS BY MAMMALIAN EXPRESSION, IS EXPRESSED IN MANY CELL-TYPES, EMBO JOURNAL 10: 2821 (1991). (10.1002/j.1460-2075.1991.tb07831.x) / EMBO JOURNAL (1991)
10.1126/science.8266077
PARK, L.S., CHARACTERIZATION OF THE CELL-SURFACE RECEPTOR FOR GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 4177 (1986). (10.1016/S0021-9258(17)35642-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1986)
PRICE, V, EXPRESSION, PURIFICATION AND CHARACTERIZATION OF RECOMBINANT MURINE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND BOVINE INTERLEUKIN-2 FROM YEAST, GENE 55: 287 (1987). (10.1016/0378-1119(87)90288-5) / GENE (1987)
10.1126/science.8266078
SRINIVASAN, S, AN AUTOMATED-METHOD FOR MODELING PROTEINS ON KNOWN TEMPLATES USING DISTANCE GEOMETRY, PROTEIN SCIENCE 2: 277 (1993). (10.1002/pro.5560020216) / PROTEIN SCIENCE (1993)
SUZUKI, J, INT IMMUNOL 1: 373 (1989). (10.1093/intimm/1.4.373) / INT IMMUNOL (1989)
SWAIN, S.L., LYMPHOKINES AND THE IMMUNE-RESPONSE - THE CENTRAL ROLE OF INTERLEUKIN-2, CURRENT OPINION IN IMMUNOLOGY 3: 304 (1991). (10.1016/0952-7915(91)90028-Y) / CURRENT OPINION IN IMMUNOLOGY (1991)
TAKESHITA, T, MONOCLONAL-ANTIBODY DEFINING A MOLECULE POSSIBLY IDENTICAL TO THE P75 SUBUNIT OF INTERLEUKIN-2 RECEPTOR, JOURNAL OF EXPERIMENTAL MEDICINE 169: 1323 (1989). (10.1084/jem.169.4.1323) / JOURNAL OF EXPERIMENTAL MEDICINE (1989)
10.1126/science.1631559
TRINCHIERI, G, RESPONSE OF RESTING HUMAN PERIPHERAL-BLOOD NATURAL-KILLER CELLS TO INTERLEUKIN-2, JOURNAL OF EXPERIMENTAL MEDICINE 160: 1147 (1984). (10.1084/jem.160.4.1147) / JOURNAL OF EXPERIMENTAL MEDICINE (1984)
URDAL, D.L., LYMPHOKINE PURIFICATION BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY, JOURNAL OF CHROMATOGRAPHY 296: 171 (1984). (10.1016/S0021-9673(01)96410-6) / JOURNAL OF CHROMATOGRAPHY (1984)
WIDMER, M.B., REGULATION OF CYTOLYTIC CELL-POPULATIONS FROM HUMAN PERIPHERAL-BLOOD BY B-CELL STIMULATORY FACTOR-I (INTERLEUKIN-4), JOURNAL OF EXPERIMENTAL MEDICINE 166: 1447 (1987). (10.1084/jem.166.5.1447) / JOURNAL OF EXPERIMENTAL MEDICINE (1987)
YODOI, J, TCGF (IL 2)-RECEPTOR INDUCING FACTOR(S) .1. REGULATION OF IL-2 RECEPTOR ON A NATURAL KILLER-LIKE CELL-LINE (YT-CELLS), JOURNAL OF IMMUNOLOGY 134: 1623 (1985). (10.4049/jimmunol.134.3.1623) / JOURNAL OF IMMUNOLOGY (1985)
ZUBLER, R.H., ACTIVATED B-CELLS EXPRESS RECEPTORS FOR, AND PROLIFERATE IN RESPONSE TO, PURE INTERLEUKIN-2, JOURNAL OF EXPERIMENTAL MEDICINE 160: 1170 (1984). (10.1084/jem.160.4.1170) / JOURNAL OF EXPERIMENTAL MEDICINE (1984)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 12:36 a.m.)
Indexed	20 hours, 15 minutes ago (Aug. 30, 2025, 1:14 p.m.)
Issued	31 years, 3 months ago (May 13, 1994)
Published	31 years, 3 months ago (May 13, 1994)
Published Print	31 years, 3 months ago (May 13, 1994)

Funders 0

None

BibTeX

@article{Grabstein_1994, title={Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor}, volume={264}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8178155}, DOI={10.1126/science.8178155}, number={5161}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Grabstein, Kenneth H. and Eisenman, June and Shanebeck, Kurt and Rauch, Charles and Srinivasan, Subhashini and Fung, Victor and Beers, Courtney and Richardson, Jane and Schoenborn, Michael A. and Ahdieh, Minoo and Johnson, Lisabeth and Alderson, Mark R. and Watson, James D. and Anderson, Dirk M. and Giri, Judith G.}, year={1994}, month=may, pages={965–968} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        30
      ]
    ],
    "date-time": "2025-08-30T17:14:24Z",
    "timestamp": 1756574064249
  },
  "reference-count": 27,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "5161",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        5,
        13
      ]
    ]
  },
  "abstract": "<jats:p>A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the \u03b2 chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.</jats:p>",
  "DOI": "10.1126/science.8178155",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        6
      ]
    ],
    "date-time": "2006-10-06T00:01:25Z",
    "timestamp": 1160092885000
  },
  "page": "965-968",
  "source": "Crossref",
  "is-referenced-by-count": 1128,
  "title": "Cloning of a T Cell Growth Factor that Interacts with the \u03b2 Chain of the Interleukin-2 Receptor",
  "prefix": "10.1126",
  "volume": "264",
  "author": [
    {
      "given": "Kenneth H.",
      "family": "Grabstein",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "June",
      "family": "Eisenman",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Kurt",
      "family": "Shanebeck",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Charles",
      "family": "Rauch",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Subhashini",
      "family": "Srinivasan",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Victor",
      "family": "Fung",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Courtney",
      "family": "Beers",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Jane",
      "family": "Richardson",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Michael A.",
      "family": "Schoenborn",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Minoo",
      "family": "Ahdieh",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Lisabeth",
      "family": "Johnson",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Mark R.",
      "family": "Alderson",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "James D.",
      "family": "Watson",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Dirk M.",
      "family": "Anderson,",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    },
    {
      "given": "Judith G.",
      "family": "Giri",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Immunex Research and Development Corporation, Seattle, WA 98101, USA."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "doi-asserted-by": "crossref",
      "first-page": "235",
      "DOI": "10.1016/0092-8674(90)90304-W",
      "volume": "63",
      "year": "1990",
      "unstructured": "ANDERSON, D.M., MOLECULAR-CLONING OF MAST-CELL GROWTH-FACTOR, A HEMATOPOIETIN THAT IS ACTIVE IN BOTH MEMBRANE-BOUND AND SOLUBLE FORMS, CELL 63: 235 (1990).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "crossref",
      "first-page": "350",
      "DOI": "10.1016/0167-5699(90)90139-Z",
      "volume": "11",
      "year": "1990",
      "unstructured": "BAZAN, J.F., HEMATOPOIETIC RECEPTORS AND HELICAL CYTOKINES, IMMUNOLOGY TODAY 11: 350 (1990).",
      "journal-title": "IMMUNOLOGY TODAY"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1631562"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "crossref",
      "first-page": "610",
      "DOI": "10.1038/321610a0",
      "volume": "321",
      "year": "1986",
      "unstructured": "BENVENISTE, E.N., STIMULATION OF OLIGODENDROGLIAL PROLIFERATION AND MATURATION BY INTERLEUKIN-2, NATURE 321: 610 (1986).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.3500515"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "crossref",
      "first-page": "1096",
      "DOI": "10.1080/01621459.1955.10501294",
      "volume": "50",
      "year": "1955",
      "unstructured": "DUNNETT, C.W., A MULTIPLE COMPARISON PROCEDURE FOR COMPARING SEVERAL TREATMENTS WITH A CONTROL, JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION 50: 1096 (1955).",
      "journal-title": "JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "crossref",
      "first-page": "154",
      "DOI": "10.1038/268154a0",
      "volume": "268",
      "year": "1977",
      "unstructured": "GILLIS, S, LONG-TERM CULTURE OF TUMOR-SPECIFIC CYTOTOXIC T-CELLS, NATURE 268: 154 (1977).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_8_1",
      "unstructured": "GIRI J COMMUNICATION."
    },
    {
      "key": "e_1_2_1_9_1",
      "unstructured": "GRABSTEIN K COMMUNICATION."
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "crossref",
      "first-page": "1405",
      "DOI": "10.1084/jem.163.6.1405",
      "volume": "163",
      "year": "1986",
      "unstructured": "GRABSTEIN, K, PURIFICATION TO HOMOGENEITY OF B-CELL STIMULATING FACTOR - A MOLECULE THAT STIMULATES PROLIFERATION OF MULTIPLE LYMPHOKINE-DEPENDENT CELL-LINES, JOURNAL OF EXPERIMENTAL MEDICINE 163: 1405 (1986).",
      "journal-title": "JOURNAL OF EXPERIMENTAL MEDICINE"
    },
    {
      "key": "e_1_2_1_11_1",
      "first-page": "2762",
      "volume": "42",
      "year": "1983",
      "unstructured": "GREENBERGER, J.S., INTERLEUKIN 3-DEPENDENT HEMATOPOIETIC PROGENITOR-CELL LINES, FEDERATION PROCEEDINGS 42: 2762 (1983).",
      "journal-title": "FEDERATION PROCEEDINGS"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.8266076"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "crossref",
      "first-page": "2821",
      "DOI": "10.1002/j.1460-2075.1991.tb07831.x",
      "volume": "10",
      "year": "1991",
      "unstructured": "MCMAHAN, C.J., A NOVEL IL-1 RECEPTOR, CLONED FROM B-CELLS BY MAMMALIAN EXPRESSION, IS EXPRESSED IN MANY CELL-TYPES, EMBO JOURNAL 10: 2821 (1991).",
      "journal-title": "EMBO JOURNAL"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.8266077"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "crossref",
      "first-page": "4177",
      "DOI": "10.1016/S0021-9258(17)35642-9",
      "volume": "261",
      "year": "1986",
      "unstructured": "PARK, L.S., CHARACTERIZATION OF THE CELL-SURFACE RECEPTOR FOR GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 4177 (1986).",
      "journal-title": "JOURNAL OF BIOLOGICAL CHEMISTRY"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "crossref",
      "first-page": "287",
      "DOI": "10.1016/0378-1119(87)90288-5",
      "volume": "55",
      "year": "1987",
      "unstructured": "PRICE, V, EXPRESSION, PURIFICATION AND CHARACTERIZATION OF RECOMBINANT MURINE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND BOVINE INTERLEUKIN-2 FROM YEAST, GENE 55: 287 (1987).",
      "journal-title": "GENE"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.8266078"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1002/pro.5560020216",
      "volume": "2",
      "year": "1993",
      "unstructured": "SRINIVASAN, S, AN AUTOMATED-METHOD FOR MODELING PROTEINS ON KNOWN TEMPLATES USING DISTANCE GEOMETRY, PROTEIN SCIENCE 2: 277 (1993).",
      "journal-title": "PROTEIN SCIENCE"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "crossref",
      "first-page": "373",
      "DOI": "10.1093/intimm/1.4.373",
      "volume": "1",
      "year": "1989",
      "unstructured": "SUZUKI, J, INT IMMUNOL 1: 373 (1989).",
      "journal-title": "INT IMMUNOL"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "crossref",
      "first-page": "304",
      "DOI": "10.1016/0952-7915(91)90028-Y",
      "volume": "3",
      "year": "1991",
      "unstructured": "SWAIN, S.L., LYMPHOKINES AND THE IMMUNE-RESPONSE - THE CENTRAL ROLE OF INTERLEUKIN-2, CURRENT OPINION IN IMMUNOLOGY 3: 304 (1991).",
      "journal-title": "CURRENT OPINION IN IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "1323",
      "DOI": "10.1084/jem.169.4.1323",
      "volume": "169",
      "year": "1989",
      "unstructured": "TAKESHITA, T, MONOCLONAL-ANTIBODY DEFINING A MOLECULE POSSIBLY IDENTICAL TO THE P75 SUBUNIT OF INTERLEUKIN-2 RECEPTOR, JOURNAL OF EXPERIMENTAL MEDICINE 169: 1323 (1989).",
      "journal-title": "JOURNAL OF EXPERIMENTAL MEDICINE"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1631559"
    },
    {
      "key": "e_1_2_1_23_1",
      "doi-asserted-by": "crossref",
      "first-page": "1147",
      "DOI": "10.1084/jem.160.4.1147",
      "volume": "160",
      "year": "1984",
      "unstructured": "TRINCHIERI, G, RESPONSE OF RESTING HUMAN PERIPHERAL-BLOOD NATURAL-KILLER CELLS TO INTERLEUKIN-2, JOURNAL OF EXPERIMENTAL MEDICINE 160: 1147 (1984).",
      "journal-title": "JOURNAL OF EXPERIMENTAL MEDICINE"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "crossref",
      "first-page": "171",
      "DOI": "10.1016/S0021-9673(01)96410-6",
      "volume": "296",
      "year": "1984",
      "unstructured": "URDAL, D.L., LYMPHOKINE PURIFICATION BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY, JOURNAL OF CHROMATOGRAPHY 296: 171 (1984).",
      "journal-title": "JOURNAL OF CHROMATOGRAPHY"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "crossref",
      "first-page": "1447",
      "DOI": "10.1084/jem.166.5.1447",
      "volume": "166",
      "year": "1987",
      "unstructured": "WIDMER, M.B., REGULATION OF CYTOLYTIC CELL-POPULATIONS FROM HUMAN PERIPHERAL-BLOOD BY B-CELL STIMULATORY FACTOR-I (INTERLEUKIN-4), JOURNAL OF EXPERIMENTAL MEDICINE 166: 1447 (1987).",
      "journal-title": "JOURNAL OF EXPERIMENTAL MEDICINE"
    },
    {
      "key": "e_1_2_1_26_1",
      "doi-asserted-by": "crossref",
      "first-page": "1623",
      "DOI": "10.4049/jimmunol.134.3.1623",
      "volume": "134",
      "year": "1985",
      "unstructured": "YODOI, J, TCGF (IL 2)-RECEPTOR INDUCING FACTOR(S) .1. REGULATION OF IL-2 RECEPTOR ON A NATURAL KILLER-LIKE CELL-LINE (YT-CELLS), JOURNAL OF IMMUNOLOGY 134: 1623 (1985).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "crossref",
      "first-page": "1170",
      "DOI": "10.1084/jem.160.4.1170",
      "volume": "160",
      "year": "1984",
      "unstructured": "ZUBLER, R.H., ACTIVATED B-CELLS EXPRESS RECEPTORS FOR, AND PROLIFERATE IN RESPONSE TO, PURE INTERLEUKIN-2, JOURNAL OF EXPERIMENTAL MEDICINE 160: 1170 (1984).",
      "journal-title": "JOURNAL OF EXPERIMENTAL MEDICINE"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.8178155",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        15
      ]
    ],
    "date-time": "2024-01-15T05:36:02Z",
    "timestamp": 1705296962000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.8178155"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        5,
        13
      ]
    ]
  },
  "references-count": 27,
  "journal-issue": {
    "issue": "5161",
    "published-print": {
      "date-parts": [
        [
          1994,
          5,
          13
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.8178155"
  ],
  "URL": "http://dx.doi.org/10.1126/science.8178155",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1994,
        5,
        13
      ]
    ]
  }
}