DOI: 10.1126/science.8146655. Binding and Suppression of the Myc Transcriptional Activation Domain by p107

Binding and Suppression of the Myc Transcriptional Activation Domain by p107

10.1126/science.8146655

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

An amino-terminal transactivation domain is required for Myc to function as a transcription factor controlling cell proliferation, differentiation, and apoptosis. A complementary DNA expression library was screened with a Myc fusion protein to identify proteins interacting with this domain, and a clone encoding the Rb-related p107 protein was isolated. The p107 protein was shown to associate with Myc in vivo and to suppress the activity of the Myc transactivation domain. However, mutant forms of Myc from Burkitt lymphoma cells, which contain sequence alterations in the transactivation domain, were resistant to p107-mediated suppression. Thus, disruption of a regulatory interaction between Myc and p107 may be important in tumorigenesis.

Bibliography

Gu, W., Bhatia, K., Magrath, lan T., Dang, C. V., & Dalla-Favera, R. (1994). Binding and Suppression of the Myc Transcriptional Activation Domain by p107. Science, 264(5156), 251â254.

Authors 5

Wei Gu (first)
Kishor Bhatia (additional)
lan T. Magrath (additional)
Chi V. Dang (additional)
Riccardo Dalla-Favera (additional)

References 41 Referenced 177

AMATI, B, TRANSCRIPTIONAL ACTIVATION BY THE HUMAN C-MYC ONCOPROTEIN IN YEAST REQUIRES INTERACTION WITH MAX, NATURE 359: 423 (1992). (10.1038/359423a0) / NATURE (1992)
AYER, D.E., MAD - A HETERODIMERIC PARTNER FOR MAX THAT ANTAGONIZES MYC TRANSCRIPTIONAL ACTIVITY, CELL 72: 211 (1993). (10.1016/0092-8674(93)90661-9) / CELL (1993)
AYER, D.E., A SWITCH FROM MYC-MAX TO MAD-MAX HETEROCOMPLEXES ACCOMPANIES MONOCYTE/MACROPHAGE DIFFERENTIATION, GENES & DEVELOPMENT 7: 2110 (1993). (10.1101/gad.7.11.2110) / GENES & DEVELOPMENT (1993)
BHATIA, K, NATURE GENETICS 5: 56 (1993). (10.1038/ng0993-56) / NATURE GENETICS (1993)
BHATIA K unpublished data.
BLACKWOOD, E.M., MYC AND MAX ASSOCIATE INVIVO, GENES & DEVELOPMENT 6: 71 (1992). (10.1101/gad.6.1.71) / GENES & DEVELOPMENT (1992)
10.1126/science.2006410
10.1126/science.1589769
CAO, L, INDEPENDENT BINDING OF THE RETINOBLASTOMA PROTEIN AND P107 TO THE TRANSCRIPTION FACTOR E2F, NATURE 355: 176 (1992). (10.1038/355176a0) / NATURE (1992)
10.1016/0092-8674(91)90557-F
CZIEPLUCH, C, ACTIVATION OF GENE-TRANSCRIPTION BY THE AMINO-TERMINUS OF THE N-MYC PROTEIN DOES NOT REQUIRE ASSOCIATION WITH THE PROTEIN ENCODED BY THE RETINOBLASTOMA SUPPRESSOR GENE RB1, ONCOGENE 8: 2833 (1993). / ONCOGENE (1993)
Dalla-Favera, R., Causes and Consequences of Chromosomal Translocations: 313 (1993). / Causes and Consequences of Chromosomal Translocations (1993)
EVAN, G.I., INDUCTION OF APOPTOSIS IN FIBROBLASTS BY C-MYC PROTEIN, CELL 69: 119 (1992). (10.1016/0092-8674(92)90123-T) / CELL (1992)
EWEN, M.E., AN N-TERMINAL TRANSFORMATION-GOVERNING SEQUENCE OF SV40 LARGE T-ANTIGEN CONTRIBUTES TO THE BINDING OF BOTH P110RB AND A 2ND CELLULAR PROTEIN, P120, CELL 58: 257 (1989). (10.1016/0092-8674(89)90840-4) / CELL (1989)
10.1016/0092-8674(91)90038-Z
10.1126/science.1532457
10.1126/science.1532458
GRIGNANI, F, NEGATIVE AUTOREGULATION OF C-MYC GENE-EXPRESSION IS INACTIVATED IN TRANSFORMED-CELLS, EMBO JOURNAL 9: 3913 (1990). (10.1002/j.1460-2075.1990.tb07612.x) / EMBO JOURNAL (1990)
GU, W, OPPOSITE REGULATION OF GENE-TRANSCRIPTION AND CELL-PROLIFERATION BY C-MYC AND MAX, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 2935 (1993). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1993)
GU W unpublished data.
HATEBOER, J, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 8489 (1993). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1993)
HERCHBACH, B.M., ANN REV CELL BIOL 9: 479 (1993). (10.1146/annurev.cb.09.110193.002403) / ANN REV CELL BIOL (1993)
HIEBERT, S.W., THE INTERACTION OF RB WITH E2F COINCIDES WITH AN INHIBITION OF THE TRANSCRIPTIONAL ACTIVITY OF E2F, GENES & DEVELOPMENT 6: 177 (1992). (10.1101/gad.6.2.177) / GENES & DEVELOPMENT (1992)
10.1002/j.1460-2075.1990.tb08221.x
KATO, G.J., MAX - FUNCTIONAL DOMAINS AND INTERACTION WITH C-MYC, GENES & DEVELOPMENT 6: 81 (1992). (10.1101/gad.6.1.81) / GENES & DEVELOPMENT (1992)
KATO, G.J., AN AMINO-TERMINAL C-MYC DOMAIN REQUIRED FOR NEOPLASTIC TRANSFORMATION ACTIVATES TRANSCRIPTION, MOLECULAR AND CELLULAR BIOLOGY 10: 5914 (1990). / MOLECULAR AND CELLULAR BIOLOGY (1990)
KRETZNER, L, MYC AND MAX PROTEINS POSSESS DISTINCT TRANSCRIPTIONAL ACTIVITIES, NATURE 359: 426 (1992). (10.1038/359426a0) / NATURE (1992)
Lombardi, L., Cell 49: 161 (1987). (10.1016/0092-8674(87)90556-3) / Cell (1987)
LUSCHER, B, NEW LIGHT ON MYC AND MYB .1. MYC, GENES & DEVELOPMENT 4: 2025 (1990). (10.1101/gad.4.12a.2025) / GENES & DEVELOPMENT (1990)
MARCU, K.B., MYC FUNCTION AND REGULATION, ANNUAL REVIEW OF BIOCHEMISTRY 61: 809 (1992). (10.1146/annurev.bi.61.070192.004113) / ANNUAL REVIEW OF BIOCHEMISTRY (1992)
MURPHY J unpublished data.
QIN, X.Q., IDENTIFICATION OF A GROWTH SUPPRESSION DOMAIN WITHIN THE RETINOBLASTOMA GENE-PRODUCT, GENES & DEVELOPMENT 6: 953 (1992). (10.1101/gad.6.6.953) / GENES & DEVELOPMENT (1992)
10.1038/352541a0
SCHWARZ, J.K., INTERACTIONS OF THE P107 AND RB PROTEINS WITH E2F DURING THE CELL-PROLIFERATION RESPONSE, EMBO JOURNAL 12: 1013 (1993). (10.1002/j.1460-2075.1993.tb05742.x) / EMBO JOURNAL (1993)
SET, A, MOL CELL BIOL 13: 4125 (1993). / MOL CELL BIOL (1993)
SETH, A, A PHOSPHORYLATION SITE LOCATED IN THE NH2-TERMINAL DOMAIN OF C-MYC INCREASES TRANSACTIVATION OF GENE-EXPRESSION, JOURNAL OF BIOLOGICAL CHEMISTRY 266: 23521 (1991). (10.1016/S0021-9258(18)54312-X) / JOURNAL OF BIOLOGICAL CHEMISTRY (1991)
10.1126/science.1378649
WEINTRAUB, S.J., RETINOBLASTOMA PROTEIN SWITCHES THE E2F SITE FROM POSITIVE TO NEGATIVE ELEMENT, NATURE 358: 259 (1992). (10.1038/358259a0) / NATURE (1992)
YANO, T, CLUSTERED MUTATIONS IN THE 2ND EXON OF THE MYC GENE IN SPORADIC BURKITT-LYMPHOMA, ONCOGENE 8: 2741 (1993). / ONCOGENE (1993)
ZHU, L, INHIBITION OF CELL-PROLIFERATION BY P107, A RELATIVE OF THE RETINOBLASTOMA PROTEIN, GENES & DEVELOPMENT 7: 1111 (1993). (10.1101/gad.7.7a.1111) / GENES & DEVELOPMENT (1993)
ZMANANIAN, M, EMBO J 11: 2603 (1992). (10.1002/j.1460-2075.1992.tb05325.x) / EMBO J (1992)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 8:01 p.m.)
Deposited	1 year, 7 months ago (Jan. 15, 2024, 12:26 a.m.)
Indexed	2 days, 16 hours ago (Sept. 3, 2025, 6:41 a.m.)
Issued	31 years, 4 months ago (April 8, 1994)
Published	31 years, 4 months ago (April 8, 1994)
Published Print	31 years, 4 months ago (April 8, 1994)

Funders 0

None

BibTeX

@article{Gu_1994, title={Binding and Suppression of the Myc Transcriptional Activation Domain by p107}, volume={264}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.8146655}, DOI={10.1126/science.8146655}, number={5156}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Gu, Wei and Bhatia, Kishor and Magrath, lan T. and Dang, Chi V. and Dalla-Favera, Riccardo}, year={1994}, month=apr, pages={251–254} }

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